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To date, there have been no reported cases of <jats:italic>A. phagocytophilum<\/jats:italic> infection found in both the biting tick and the patient following a tick bite.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>An 81-year-old woman presented with fever following a tick bite, with the tick still intact on her body. The patient was diagnosed with HGA. The tick was identified as <jats:italic>Ixodes nipponensis<\/jats:italic> by morphological and molecular biological detection methods targeting the 16S rRNA gene. The patient\u2019s blood was cultured after inoculation into the human promyelocytic leukemia cell line HL-60. <jats:italic>A. phagocytophilum<\/jats:italic> growth was confirmed via culture and isolation. <jats:italic>A. phagocytophilum<\/jats:italic> was identified in both the tick and the patient\u2019s blood by <jats:italic>Anaplasma<\/jats:italic>-specific <jats:italic>groEL-<\/jats:italic> and <jats:italic>ankA-<\/jats:italic>based nested polymerase chain reaction followed by sequencing. Moreover, a four-fold elevation in antibodies was observed in the patient\u2019s blood.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>We report a case of a patient diagnosed with HGA following admission for fever due to a tick bite. <jats:italic>A. phagocytophilum<\/jats:italic> was identified in both the tick and the patient, and <jats:italic>A. phagocytophilum<\/jats:italic> was successfully cultured. The present study suggests the need to investigate the possible incrimination of <jats:italic>I. nipponensis<\/jats:italic> as a vector for HGA in Korea.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12879-020-05522-5","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T12:03:19Z","timestamp":1605096199000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["First identification of Anaplasma phagocytophilum in both a biting tick Ixodes nipponensis and a patient in Korea: a case report"],"prefix":"10.1186","volume":"20","author":[{"given":"Seung Hun","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na-Ri","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choon-Mee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungdo","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na Ra","family":"Yun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6373-0922","authenticated-orcid":false,"given":"Dong-Min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Sik","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,11,11]]},"reference":[{"key":"5522_CR1","doi-asserted-by":"publisher","first-page":"403","DOI":"10.4269\/ajtmh.16-0570","volume":"97","author":"CM Kim","year":"2017","unstructured":"Kim CM, Kim SW, Kim DM, Yoon NR, Jha P, Jang SJ, et al. 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The patient provided written informed consent to participate in the study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal upon request.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors do not have any commercial interests or other associations, which might pose a conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"826"}}