{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T18:25:29Z","timestamp":1750098329752,"version":"3.37.3"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Major Project of China","award":["2018ZX09711003"],"award-info":[{"award-number":["2018ZX09711003"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Hydroa Vacciniforme-like Lymphoproliferative Disorder (HV-LPD) is the name given to a group of Epstein-Barr virus (EBV)-associated diseases. It resembles hydroa vacciniforme (HV), the rarest form of photosensitivity, and is a T-cell disorder associated with an Epstein-Barr virus infection. The majority of diagnosed cases occur in East Asia and South America. It is rare in the United States and Europe. Multiple studies have revealed the clinical manifestation of an enlarged liver, but no gold standard such as pathology has yet supported this as a clinical sign of HV-LPD.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>Here, we report a case of a 34-year-old Asian female with definite liver invasion. The patient had complained of a recurring facial rash for many years<jats:bold>.<\/jats:bold> The patient was admitted to the hospital because of an enlarged liver. After hospitalization, she was given an EB virus nucleic acid test. The EB virus nucleic acid test was positive, and pathological examination suggested that HV-LPD had invaded the skin, bone marrow, and liver. After being given antiviral treatment, the patient\u2019s symptoms were mitigated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our case confirms the liver damage was caused by HV-LPD and the effectiveness of antiviral treatment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-020-05697-x","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T20:05:26Z","timestamp":1609963526000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hydroa Vacciniforme-like Lymphoproliferative disorder in an adult invades the liver and bone marrow with clear pathological evidence: a case report and literature review"],"prefix":"10.1186","volume":"21","author":[{"given":"Xiankun","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aibin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanli","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6481-4781","authenticated-orcid":false,"given":"Zhihai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,6]]},"reference":[{"key":"5697_CR1","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1111\/j.1365-2133.2010.09789.x","volume":"163","author":"L Verneuil","year":"2010","unstructured":"Verneuil L, Gouarin S, Comoz F, Agbalika F, Creveuil C, Varna M, et al. Epstein-Barr virus involvement in the pathogenesis of hydroa vacciniforme: an assessment of seven adult patients with long-term follow-up. Br J Dermatol. 2010;163:174\u201382.","journal-title":"Br J Dermatol"},{"key":"5697_CR2","first-page":"278","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"L Quintanilla-Martinez","year":"2008","unstructured":"Quintanilla-Martinez L, Kimura H, Jaffe ES. EBV+T-cell lymphoma of childhood. In: Swerdlow SH, Campo E, Harris NL, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon: WHO Press; 2008: 278\u2013280."},{"key":"5697_CR3","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1182\/blood-2016-01-643569","volume":"127","author":"SH Swerdlow","year":"2016","unstructured":"Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016;127:2375\u201390.","journal-title":"Blood"},{"key":"5697_CR4","doi-asserted-by":"crossref","unstructured":"Lyapichev KA, Sukswai N, Wang XI, Khoury JD, Medeiros LJ. Hydroa Vacciniforme-Like Lymphoproliferative Disorder With Progression to EBV+ Cytotoxic Peripheral T-Cell Lymphoma. Am J Dermatopathol. 2019.","DOI":"10.1097\/DAD.0000000000001494"},{"key":"5697_CR5","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1053\/j.semdp.2016.11.003","volume":"34","author":"AA Gru","year":"2017","unstructured":"Gru AA, Jaffe ES. Cutaneous EBV-related lymphoproliferative disorders. Semin Diagn Pathol. 2017;34:60\u201375.","journal-title":"Semin Diagn Pathol"},{"key":"5697_CR6","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.3324\/haematol.2017.174177","volume":"103","author":"K Kawamoto","year":"2018","unstructured":"Kawamoto K, Miyoshi H, Suzuki T, Kozai Y, Kato K, Miyahara M, et al. A distinct subtype of Epstein-Barr virus-positive T\/NK-cell lymphoproliferative disorder: adult patients with chronic active Epstein-Barr virus infection-like features. Haematologica. 2018;103:1018\u201328.","journal-title":"Haematologica"},{"key":"5697_CR7","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s13000-019-0859-4","volume":"14","author":"N Guo","year":"2019","unstructured":"Guo N, Chen Y, Wang Y, Huang Y, Feng Y, Li M, et al. Clinicopathological categorization of hydroa vacciniforme-like lymphoproliferative disorder: an analysis of prognostic implications and treatment based on 19 cases. Diagn Pathol. 2019;14:82.","journal-title":"Diagn Pathol"},{"key":"5697_CR8","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1097\/DAD.0000000000000158","volume":"37","author":"JA Plaza","year":"2015","unstructured":"Plaza JA, Sangueza M. Hydroa vacciniforme-like lymphoma with primarily periorbital swelling: 7 cases of an atypical clinical manifestation of this rare cutaneous T-cell lymphoma. Am J Dermatopathol. 2015;37:20\u20135.","journal-title":"Am J Dermatopathol"},{"key":"5697_CR9","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1097\/DAD.0000000000001229","volume":"41","author":"PF Wen","year":"2019","unstructured":"Wen PF, Zhang M, Wang TT, Liu HJ, Zhang WY, Liu WP, et al. Comparative study of the clinical pathology, Immunophenotype, Epstein-Barr virus infection status, and gene rearrangements in adult and child patients with Hydroa Vacciniforme-like Lymphoproliferative disorder. Am J Dermatopathol. 2019;41:7\u201315.","journal-title":"Am J Dermatopathol"},{"key":"5697_CR10","doi-asserted-by":"publisher","first-page":"3101","DOI":"10.1182\/blood-2013-05-502203","volume":"122","author":"L Quintanilla-Martinez","year":"2013","unstructured":"Quintanilla-Martinez L, Ridaura C, Nagl F, S\u00e1ez-de-Ocariz M, Dur\u00e1n-McKinster C, Ruiz-Maldonado R, et al. Hydroa vacciniforme-like lymphoma: a chronic EBV+ lymphoproliferative disorder with risk to develop a systemic lymphoma. Blood. 2013;122:3101\u201310.","journal-title":"Blood"},{"key":"5697_CR11","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.jaad.2019.01.011","volume":"81","author":"Y Liu","year":"2019","unstructured":"Liu Y, Ma C, Wang G, Wang L. Hydroa vacciniforme-like lymphoproliferative disorder: Clinicopathologic study of 41 cases. J Am Acad Dermatol. 2019;81:534\u201340.","journal-title":"J Am Acad Dermatol"},{"key":"5697_CR12","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/bjd.13411","volume":"172","author":"T Miyake","year":"2015","unstructured":"Miyake T, Yamamoto T, Hirai Y, Otsuka M, Hamada T, Tsuji K, et al. Survival rates and prognostic factors of Epstein-Barr virus-associated hydroa vacciniforme and hypersensitivity to mosquito bites. Br J Dermatol. 2015;172:56\u201363.","journal-title":"Br J Dermatol"},{"key":"5697_CR13","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1097\/DAD.0000000000000880","volume":"40","author":"X Zhang","year":"2018","unstructured":"Zhang X, Wang T, Wang L. Hydroa Vacciniforme-like lymphoma in Tibetan children: 2 cases and a literature review. Am J Dermatopathol. 2018;40:358\u201361.","journal-title":"Am J Dermatopathol"},{"key":"5697_CR14","doi-asserted-by":"publisher","first-page":"393","DOI":"10.2340\/00015555-0670","volume":"89","author":"J Lysell","year":"2009","unstructured":"Lysell J, Wiegleb Edstr\u00f6m D, Linde A, Carlsson G, Malmros-Svennilson J, Westermark A, et al. Antiviral therapy in children with hydroa vacciniforme. Acta Derm Venereol. 2009;89:393\u20137.","journal-title":"Acta Derm Venereol"},{"key":"5697_CR15","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1038\/bmt.2010.176","volume":"46","author":"NK El-Mallawany","year":"2011","unstructured":"El-Mallawany NK, Geller L, Bollard CM, Wistinghausen B, Mussai F, Wayne AS, et al. Long-term remission in a child with refractory EBV(+) hydroa vacciniforme-like T-cell lymphoma through sequential matched EBV(+)-related allogeneic hematopoietic SCT followed by donor-derived EBV-specific cytotoxic T-lymphocyte immunotherapy. Bone Marrow Transplant. 2011;46:759\u201361.","journal-title":"Bone Marrow Transplant"},{"key":"5697_CR16","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1182\/blood-2011-10-381921","volume":"119","author":"H Kimura","year":"2012","unstructured":"Kimura H, Ito Y, Kawabe S, Gotoh K, Takahashi Y, Kojima S, et al. EBV-associated T\/NK-cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases. Blood. 2012;119:673\u201386.","journal-title":"Blood"},{"key":"5697_CR17","doi-asserted-by":"publisher","first-page":"2753","DOI":"10.1182\/blood.2018893750","volume":"133","author":"JI Cohen","year":"2019","unstructured":"Cohen JI, Manoli I, Dowdell K, Krogmann TA, Tamura D, Radecki P, et al. Hydroa vacciniforme-like lymphoproliferative disorder: an EBV disease with a low risk of systemic illness in whites. Blood. 2019;133:2753\u201364.","journal-title":"Blood"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-020-05697-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12879-020-05697-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-020-05697-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T20:18:40Z","timestamp":1609964320000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-020-05697-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,6]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["5697"],"URL":"https:\/\/doi.org\/10.1186\/s12879-020-05697-x","relation":{},"ISSN":["1471-2334"],"issn-type":[{"type":"electronic","value":"1471-2334"}],"subject":[],"published":{"date-parts":[[2021,1,6]]},"assertion":[{"value":"3 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Ethics Committee of Beijing Ditan Hospital, Capital Medical University gave approval for this study, and informed written consent was obtained from the patient.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed written consent was obtained from the patient for publication of this case report and accompanying images.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"17"}}