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Although the rising rates of VRE infections are being reported elsewhere in the worldwide; there is limited national pooled data in Ethiopia. Therefore, this study was aimed to estimate the pooled prevalence of VRE and antimicrobial resistance profiles of<jats:italic>enterococci<\/jats:italic>in Ethiopia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Literature search was done at PubMed, EMBASE, Google scholar, African Journals online (AJOL) and Addis Ababa University repository following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. Both published and unpublished studies reporting the prevalence of VRE until June 30, 2019 were included. Data were extracted using Microsoft Excel and copied to Comprehensive Meta-analysis (CMA 2.0) for analysis. Pooled estimate of VRE was computed using the random effects model and the 95% CIs. The level of heterogeneity was assessed using Cochran\u2019s Q and I<jats:sup>2<\/jats:sup>tests. Publication bias was checked by visual inspection of funnel plots and Begg\u2019s and\/or Egger\u2019s test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty studies fulfilled the eligibility criteria and found with relevant data. A total of 831<jats:italic>enterococci<\/jats:italic>and 71 VRE isolates were included in the analysis. The pooled prevalence of VRE was 14.8% (95% CI; 8.7\u201324.3;<jats:italic>I<\/jats:italic><jats:sup><jats:italic>2<\/jats:italic><\/jats:sup>\u2009=\u200974.05%;<jats:italic>P<\/jats:italic>\u2009&lt;\u2009\u00a00.001). Compared to vancomycin resistance,<jats:italic>enterococci<\/jats:italic>had higher rate of resistance to Penicillin (60.7%), Amoxicillin (56.5%), Doxycycline (55.1%) and Tetracycline (53.7%). Relatively low rate of resistance was found for Daptomycin and Linezolid with a pooled estimate of 3.2% (95% CI, 0.5\u201319.7%) and 9.9% (95% CI, 2.8\u201329.0%); respectively. The overall pooled multidrug resistance (MDR) rate of<jats:italic>enterococci<\/jats:italic>was 60.0% (95% CI, 42.9\u201375.0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of VRE and drug resistant<jats:italic>enterococci<\/jats:italic>are on the rise in Ethiopia. Enterococcal isolates showed resistance to one or more of the commonly prescribed drugs in different or the same drug lines. Multidrug resistant (MDR)<jats:italic>enterococci<\/jats:italic>were also found. Although the rates were low, the emergence of resistance to Daptomycin and Linezolid is an alarm for searching new ways for the treatment and control of VRE infections. Adherence to antimicrobial stewardship, comprehensive testing and ongoing monitoring of VRE infections in the health care settings are required.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12879-020-4833-2","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T15:02:51Z","timestamp":1581433371000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Prevalence of Vancomycin resistant enterococci (VRE) in Ethiopia: a systematic review and meta-analysis"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2362-5500","authenticated-orcid":false,"given":"Addisu","family":"Melese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chalachew","family":"Genet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tesfaye","family":"Andualem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,2,11]]},"reference":[{"issue":"7","key":"4833_CR1","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1179\/2047773215Y.0000000030","volume":"109","author":"Francesca Prestinaci","year":"2015","unstructured":"Francesca Prestinaci, P.P., Annalisa Pantosti, Antimicrobial resistance: a global multifaceted phenomenon. 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