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The main study objective was to analyze epidemiological and clinical differences between IE by methicillin-resistant versus methicillin-susceptible\n                      <jats:italic>SA<\/jats:italic>\n                      (MRSA vs. MSSA) and to examine prognostic factors for SA endocarditis, including methicillin resistance and vancomycin minimum inhibitory concentration (MIC) values &gt;\u20091 \u03bcg\/mL to MRSA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with SA endocarditis were consecutively and prospectively recruited from the Andalusia endocarditis cohort between 1984 and January 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We studied 437 patients with SA endocarditis, which was MRSA in 13.5% of cases. A greater likelihood of history of COPD (OR 3.19; 95% CI 1.41\u20137.23), invasive procedures, or recognized infection focus in the 3 months before IE onset (OR 2.9; 95% CI 1.14\u20137.65) and of diagnostic delay (OR 3.94; 95% CI 1.64\u20139.5) was observed in patients with MRSA versus MSSA endocarditis.<\/jats:p>\n                    <jats:p>\n                      The one-year mortality rate due to SA endocarditis was 44.3% and associated with decade of endocarditis onset (1985\u20131999) (OR 8.391; 95% CI (2.82\u201324.9); 2000\u20132009 (OR 6.4; 95% CI 2.92\u201314.06); active neoplasm (OR 6.63; 95% CI 1.7\u201325.5) and sepsis (OR 2.28; 95% CI 1.053\u20134.9). Methicillin resistance was not associated with higher IE-related mortality (49.7 vs. 43.1%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.32).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MRSA IE is associated with COPD, previous invasive procedure or recognized infection focus, and nosocomial or healthcare-related origin. Methicillin resistance does not appear to be a decisive prognostic factor for SA IE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12879-020-4895-1","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T10:02:44Z","timestamp":1582279364000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Clinical and prognostic differences between methicillin-resistant and methicillin-susceptible Staphylococcus aureus infective endocarditis"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6394-5728","authenticated-orcid":false,"given":"Carmen","family":"Hidalgo-Tenorio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"G\u00e1lvez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Mart\u00ednez-Marcos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Plata-Ciezar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"De La Torre-Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Eduardo","family":"L\u00f3pez-Cort\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Noureddine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Reguera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Vinuesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Victoria","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Ojeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Luque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Lomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Antonio","family":"Lepe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ar\u00edstides","family":"de Alarc\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,2,21]]},"reference":[{"key":"4895_CR1","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1056\/NEJMcp1206782","volume":"368","author":"B Hoen","year":"2013","unstructured":"Hoen B, Duval X. 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Clin Infect Dis. 2015;60:741\u20139.","journal-title":"Clin Infect Dis"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-020-4895-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12879-020-4895-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-020-4895-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T19:42:40Z","timestamp":1613850160000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-020-4895-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,21]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["4895"],"URL":"https:\/\/doi.org\/10.1186\/s12879-020-4895-1","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.2.15316\/v2","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.2.15316\/v1","asserted-by":"object"}]},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,21]]},"assertion":[{"value":"12 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All procedures followed were in accordance with the ethical standards. The study was approved by the current ethical committees of participant hospitals. This prospective cohort of patients with endocarditis was approved by the ethics committee (CEIC) of the original hospital that was launched by University Hospital \u201cVirgen del Rocio\u201d, and subsequently by the other committees of participating Andalusian hospitals (CEIC of University Hospital \u201cVirgen de las Nieves\u201d, Granada; CEIC of University Hospital \u201c<i>Virgen de la Macarena\u201d, Sevilla;<\/i> CEIC of Hospital <i>\u201cJuan Ram\u00f3n Jim\u00e9nez\u201d, Huelva; CEIC of<\/i> University Hospital, Regional \u201cCarlos Haya\u201d, <i>M\u00e1laga; CEIC of<\/i> University Hospital <i>\u201cSan Cecilio\u201d, Granada; and CEIC of<\/i> University Hospital \u201c<i>Virgen de la Victoria\u201d, M\u00e1laga<\/i>)<i>.<\/i> These CEICs are integrated within the network of ethics Committes of Andalusian public health system (SSPA). CEICs are regulated by order\/Decree 439\/2010 December 14th of Andalusia. As it is an observational, non-interventionist study, it was decided as appropriate to request the verbal consent of each of the patients and that it will be included in each of the subjects\u2019 medical records.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All participants gave consent for publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"160"}}