{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T08:27:46Z","timestamp":1759480066682},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Elderly people in nursing homes are particularly vulnerable to COVID-19 due to their age, the presence of comorbidities, and community living. On March 14, 2020, at the beginning of the first epidemic wave of COVID-19 in France, a cluster was reported in a nursing home in the Nouvelle-Aquitaine region. We monitored the outbreak as well as the infection prevention and control (IPC) measures implemented.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A confirmed case was defined as laboratory-confirmed COVID-19 in a resident or staff member present in the nursing home between March 7 and May 1, 2020; and a probable case as a person presenting an acute respiratory illness after contact with a confirmed case. Symptomatic inpatient residents and symptomatic staff members were systematically tested for SARS-CoV-2. In addition, two screening sessions were held on site.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We identified 109 cases (98 confirmed, 11 probable). The attack rate was 66% among residents and 45% among staff. Half of all cases were identified during the screening sessions. One-quarter of cases had minor symptoms or were asymptomatic. The case fatality rate among residents was 29%. IPC measures were rapidly implemented such as the quarantine of residents, the reinforcement of staff personal protective equipment, and home quarantine of staff testing positive, which were supplemented in April by systematic controls at the entrance of the nursing home and the creation of additional staff break rooms.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This outbreak confirmed the considerable health impact of SARS-CoV-2 transmission in a nursing home. In addition to the implementation of IPC measures, the early detection of cases through the screening of residents and staff is essential to identify asymptomatic and pre-symptomatic cases and limit the spread of the virus.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-021-05890-6","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T09:04:07Z","timestamp":1613984647000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["High impact of COVID-19 outbreak in a nursing home in the Nouvelle-Aquitaine region, France, March to April 2020"],"prefix":"10.1186","volume":"21","author":[{"given":"A.","family":"Bernadou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bouges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Catroux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"Rigaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Laland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Lev\u00eaque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Noury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Larrieu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Acef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Habold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Cazenave-Roblot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Filleul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,22]]},"reference":[{"issue":"6","key":"5890_CR1","doi-asserted-by":"publisher","first-page":"2000094","DOI":"10.2807\/1560-7917.ES.2020.25.6.2000094","volume":"25","author":"S Bernard Stoecklin","year":"2020","unstructured":"Bernard Stoecklin S, Rolland P, Silue Y, Mailles A, Campese C, Simondon A, et al. First cases of coronavirus disease 2019 (COVID-19) in France: surveillance, investigations and control measures, January 2020. Eurosurveillance. 2020;25(6):2000094.","journal-title":"Eurosurveillance."},{"key":"5890_CR2","first-page":"11","volume-title":"COVID-19 : point \u00e9pid\u00e9miologique du 24 mars 2020","author":"Sant\u00e9 Publique France","year":"2020","unstructured":"Sant\u00e9 Publique France. COVID-19 : point \u00e9pid\u00e9miologique du 24 mars 2020. Saint-Maurice: ANSP; 2020. p. 11. [cited 31\/03\/2020]. Available from: https:\/\/www.santepubliquefrance.fr\/maladies-et-traumatismes\/maladies-et-infections-respiratoires\/infection-a-coronavirus\/documents\/bulletin-national\/covid-19-point-epidemiologique-du-24-mars-2020"},{"key":"5890_CR3","first-page":"59","volume-title":"Conduite \u00e0 tenir devant une ou plusieurs infections respiratoires aigu\u00ebs en Ehpad","author":"Haut Conseil de la sant\u00e9 publique","year":"2012","unstructured":"Haut Conseil de la sant\u00e9 publique. Conduite \u00e0 tenir devant une ou plusieurs infections respiratoires aigu\u00ebs en Ehpad. Paris: HCSP; 2012. p. 59."},{"issue":"4","key":"5890_CR4","first-page":"647","volume":"81","author":"E Bouza","year":"2020","unstructured":"Bouza E, P\u00e9rez-Granda MJ, Escribano P, Fern\u00e1ndez-Del-Rey R, Pastor I, Moure Z, et al. Outbreak of COVID-19 in a nursing home in Madrid. 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[cited 31\/03\/2020]"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-021-05890-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12879-021-05890-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-021-05890-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T09:07:33Z","timestamp":1613984853000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-021-05890-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,22]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["5890"],"URL":"https:\/\/doi.org\/10.1186\/s12879-021-05890-6","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,22]]},"assertion":[{"value":"9 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was based on data collected directly from health professionals for the purpose of an investigation led by Sant\u00e9 publique France according to its legal missions and prerogatives toward medical confidentiality. This research does not involve human beings for which French law requires the approval of an ethics committee; research involving humans is defined by French law (article L. 1121\u20131 and R1121\u20131 Code de la sant\u00e9 publique) as research aimed at improving medical or biological knowledge. The objective of this investigation conducted by Sant\u00e9 publique France was rather to identify the origin and scope of a group in order to take measures to prevent the spread of infection. Therefore, this study only had to comply with the personal data protection law [General Data Protection Regulation (Regulation (EU) 2016\/679 and Directive 95\/46\/EC) and the French data protection law (Law n\u00b078\u201317 on 06\/01\/1978 and D\u00e9cret n\u00b02019\u2013536 on 29\/05\/2019)]. Data processing was necessary for the performance of a task carried out in the public interest (article 6. E of GDPR). Informed consent was obtained from all participants (article 13 GDPR). No person under 18\u2009years was included in this investigation.All experimental protocols were approved by Sant\u00e9 publique France. All methods were carried out in accordance with the relevant guidelines and regulations of Sant\u00e9 publique France.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"198"}}