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Identifying risk factors for complicated <jats:bold><jats:italic>S. aureus<\/jats:italic><\/jats:bold> bacteraemia would aid clinicians in targeting patients that benefit from expedited investigations and escalated care.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this prospective observational cohort study, we aimed to identify risk factors associated with a complicated infection in community-onset <jats:italic>S. aureus<\/jats:italic> bacteraemia. Potential risk factors were collected from electronic medical records and included: - patient demographics, symptomology, portal of entry, and laboratory results.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We identified several potential risk factors using univariate analysis. In a multiple logistic regression model, age, haemodialysis, and entry point from a diabetic foot ulcer were all significantly protective against complications. Conversely, an unknown entry point of infection, an entry point from an indwelling medical device, and a C-reactive protein concentration of over 161\u2009mg\/L on the day of admission were all significantly associated with complications.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>We conclude that several factors are associated with complications including already conducted laboratory investigations and portal of entry of infection. These factors could aid the triage of at-risk patients for complications of <jats:italic>S. aureus<\/jats:italic> bacteraemia.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-021-05962-7","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T08:03:39Z","timestamp":1617264219000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["C-reactive protein predicts complications in community-associated S. aureus bacteraemia: a cohort study"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9613-8930","authenticated-orcid":false,"given":"Carly L.","family":"Botheras","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Bowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Cowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Athan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,1]]},"reference":[{"issue":"12","key":"5962_CR1","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1017\/ice.2015.213","volume":"36","author":"Y Rhee","year":"2015","unstructured":"Rhee Y, Aroutcheva A, Hota B, Weinstein RA, Popovich KJ. 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