{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:06:40Z","timestamp":1781186800039,"version":"3.54.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Neonatal meningitis is a severe infectious disease of the central nervous system with high morbidity and mortality. <jats:italic>Ureaplasma parvum<\/jats:italic> is extremely rare in neonatal central nervous system infection.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We herein report a case of <jats:italic>U. parvum<\/jats:italic> meningitis in a full-term neonate who presented with fever and seizure complicated with subdural hematoma. After hematoma evacuation, the seizure disappeared, though the fever remained. Cerebrospinal fluid (CSF) analysis showed inflammation with CSF pleocytosis (1135\u20131319 leukocytes\/\u03bcl, mainly lymphocytes), elevated CSF protein levels (1.36\u20132.259\u2009g\/l) and decreased CSF glucose (0.45\u20131.21\u2009mmol\/l). However, no bacterial or viral pathogens in either CSF or blood were detected by routine culture or serology. Additionally, PCR for enteroviruses and herpes simplex virus was negative. Furthermore, the CSF findings did not improve with empirical antibiotics, and the baby experienced repeated fever. Thus, we performed metagenomic next-generation sequencing (mNGS) to identify the etiology of the infection. <jats:italic>U. parvum<\/jats:italic> was identified by mNGS in CSF samples and confirmed by culture incubation on mycoplasma identification medium. The patient\u2019s condition improved after treatment with erythromycin for approximately 5\u2009weeks.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Considering the difficulty of etiological diagnosis in neonatal <jats:italic>U. parvum<\/jats:italic> meningitis, mNGS might offer a new strategy for diagnosing neurological infections.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-021-05968-1","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T10:02:54Z","timestamp":1615975374000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Neonatal Ureaplasma parvum meningitis complicated with subdural hematoma: a case report and literature review"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9682-0665","authenticated-orcid":false,"given":"Canyang","family":"Zhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,17]]},"reference":[{"issue":"Pt 12","key":"5968_CR1","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1099\/jmm.0.059840-0","volume":"62","author":"T Barichello","year":"2013","unstructured":"Barichello T, Fagundes GD, Generoso JS, Elias SG, Sim\u00f5es LR, Teixeira AL. 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A copy of the written consent form is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"268"}}