{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:26:06Z","timestamp":1790004366977,"version":"4.0.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the 2017 Xiamen Science and Technology Planning Project","award":["3502Z20171006"],"award-info":[{"award-number":["3502Z20171006"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p><jats:italic>Escherichia coli<\/jats:italic> (<jats:italic>E. coli<\/jats:italic>) is one of the important causative pathogens of neonatal invasive infection. The epidemiological and clinical profile of invasive <jats:italic>E. coli<\/jats:italic> infection in Chinese newborns is not well characterized.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Ninety-four infants with invasive <jats:italic>E. coli<\/jats:italic> infection were categorized into <jats:italic>E. coli<\/jats:italic> early onset disease (EOD) group (onset \u226472\u2009h after birth) (<jats:italic>n<\/jats:italic>\u2009=\u200946) and <jats:italic>E. coli<\/jats:italic> late onset disease (LOD) group (onset &gt;\u200972\u2009h) (<jats:italic>n<\/jats:italic>\u2009=\u200948). We compared and analyzed the clinical characteristics and drug sensitivity profile of early-onset and late-onset <jats:italic>E. coli<\/jats:italic> invasive infection in neonates.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The incidence of <jats:italic>E. coli<\/jats:italic>-EOD and <jats:italic>E.coli<\/jats:italic>-LOD was 0.45\/1000 live births (LBs) and 0.47\/1000 LBs, respectively. The incidence of gestational diabetes mellitus, perinatal fever, urinary tract infection, chorioamnionitis, and positive <jats:italic>E. coli<\/jats:italic> culture among mothers in the <jats:italic>E. coli<\/jats:italic>-EOD group were significantly higher than that in <jats:italic>E. coli<\/jats:italic>-LOD group. The incidence of premature birth, low-birth-weight, nosocomial infection, and hospitalization time were significantly higher in the <jats:italic>E. coli<\/jats:italic>-LOD group. The main disease in <jats:italic>E. coli<\/jats:italic>-EOD group was pneumonia (main clinical manifestation: dyspnea). The main disease in <jats:italic>E. coli<\/jats:italic>-LOD group was sepsis (main clinical manifestation: fever). The sensitivity rates of <jats:italic>E. coli<\/jats:italic> strains to ampicillin and piperacillin were low (25.00\u201328.79%); sensitivity to cephalosporins was also low except ceftazidime (lowest sensitivity rate: 57.14%). Sensitivity to compound preparations containing \u03b2-lactamase inhibitors was high, even for extended spectrum \u03b2-lactamase-positive strains (nearly 100%).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p><jats:italic>E. coli<\/jats:italic> is an important cause of invasive infection of newborns in Xiamen, China. <jats:italic>E. coli<\/jats:italic>-EOD was largely attributable to perinatal factors, while <jats:italic>E. coli<\/jats:italic>-LOD was largely related to nosocomial infection. Compound preparations containing \u03b2-lactamase inhibitor or carbapenem antibiotics should be preferred for neonatal invasive infection by <jats:italic>E. coli<\/jats:italic>.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-021-05981-4","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T13:02:45Z","timestamp":1616504565000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Epidemiology and antimicrobial susceptibility of invasive Escherichia coli infection in neonates from 2012 to 2019 in Xiamen, China"],"prefix":"10.1186","volume":"21","author":[{"given":"Jidong","family":"Lai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"issue":"10063","key":"5981_CR1","doi-asserted-by":"publisher","first-page":"3027","DOI":"10.1016\/S0140-6736(16)31593-8","volume":"388","author":"L Liu","year":"2016","unstructured":"Liu L, Oza S, Hogan D, Chu Y, Perin J, Zhu J, Lawn JE, Cousens S, Mathers C, Black RE. Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the sustainable development goals. Lancet. 2016;388(10063):3027\u201335. https:\/\/doi.org\/10.1016\/S0140-6736(16)31593-8.","journal-title":"Lancet."},{"issue":"11","key":"5981_CR2","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1016\/S1473-3099(19)30414-1","volume":"19","author":"U Okomo","year":"2019","unstructured":"Okomo U, Akpalu ENK, Le Doare K, Roca A, Cousens S, Jarde A, et al. Aetiology of invasive bacterial infection and antimicrobial resistance in neonates in sub-Saharan Africa: a systematic review and meta-analysis in line with the STROBE-NI reporting guidelines. Lancet Infect Dis. 2019;19(11):1219\u201334. https:\/\/doi.org\/10.1016\/S1473-3099(19)30414-1.","journal-title":"Lancet Infect Dis"},{"issue":"6","key":"5981_CR3","doi-asserted-by":"publisher","first-page":"F547","DOI":"10.1136\/archdischild-2017-313203","volume":"103","author":"B Cailes","year":"2018","unstructured":"Cailes B, Kortsalioudaki C, Buttery J, Pattnayak S, Greenough A, Matthes J, Bedford Russell A, Kennea N, Heath PT, neonIN network. Epidemiology of UK neonatal infections: the neonIN infection surveillance network. Arch Dis Child Fetal Neonatal Ed. 2018;103(6):F547\u201353. https:\/\/doi.org\/10.1136\/archdischild-2017-313203.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"10104","key":"5981_CR4","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1016\/S0140-6736(17)31002-4","volume":"390","author":"AL Shane","year":"2017","unstructured":"Shane AL, S\u00e1nchez PJ, Stoll BJ. Neonatal sepsis. Lancet. 2017;390(10104):1770\u201380. https:\/\/doi.org\/10.1016\/S0140-6736(17)31002-4.","journal-title":"Lancet."},{"issue":"11","key":"5981_CR5","doi-asserted-by":"publisher","first-page":"e0225407","DOI":"10.1371\/journal.pone.0225407","volume":"14","author":"A Berardi","year":"2019","unstructured":"Berardi A, Sforza F, Baroni L, Spada C, Ambretti S, Biasucci G, Bolognesi S, Capretti M, Carretto E, Ciccia M, Lanari M, Pedna MF, Rizzo V, Venturelli C, Tzialla C, Lucaccioni L, Reggiani MLB. Epidemiology and complications of late-onset sepsis: an Italian area-based study. PLoS One. 2019;14(11):e0225407. https:\/\/doi.org\/10.1371\/journal.pone.0225407.","journal-title":"PLoS One"},{"issue":"12","key":"5981_CR6","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1097\/INF.0000000000002492","volume":"38","author":"S Jiang","year":"2019","unstructured":"Jiang S, Hong L, Gai J, Shi J, Yang Y, Lee SK, Cao Y, REIN-EPIQ Study Group. Early-onset Sepsis among preterm neonates in China, 2015 to 2018. Pediatr Infect Dis J. 2019;38(12):1236\u201341. https:\/\/doi.org\/10.1097\/INF.0000000000002492.","journal-title":"Pediatr Infect Dis J"},{"issue":"4","key":"5981_CR7","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1177\/0009922817728699","volume":"57","author":"Z Zhao","year":"2018","unstructured":"Zhao Z, Yu JL, Zhang HB, Li JH, Li ZK. Five-year multicenter study of clinical tests of neonatal purulent meningitis. Clin Pediatr (Phila). 2018;57(4):389\u201397. https:\/\/doi.org\/10.1177\/0009922817728699.","journal-title":"Clin Pediatr (Phila)"},{"key":"5981_CR8","volume-title":"Practical Neonatology","author":"XM Shao","year":"2019","unstructured":"Shao XM, Ye HM, Qiu XS. Practical Neonatology. 5th ed. Beijing: People's Medical Publishing House; 2019.","edition":"5"},{"issue":"4","key":"5981_CR9","first-page":"252","volume":"57","author":"Neonatology Group of Pediatrics Branch of Chinese Medical Association","year":"2019","unstructured":"Neonatology Group of Pediatrics Branch of Chinese Medical Association. Expert consensus on the diagnosis and treatment of neonatal sepsis (2019 edition). Chin J Pediatr. 2019;57(4):252\u20137.","journal-title":"Chin J Pediatr"},{"issue":"8","key":"5981_CR10","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/S2213-2600(17)30214-X","volume":"5","author":"D De Luca","year":"2017","unstructured":"De Luca D, van Kaam AH, Tingay DG, Courtney SE, Danhaive O, Carnielli VP, et al. The Montreux definition of neonatal ARDS: biological and clinical background behind the description of a new entity. Lancet Respir Med. 2017;5(8):657\u201366. https:\/\/doi.org\/10.1016\/S2213-2600(17)30214-X.","journal-title":"Lancet Respir Med"},{"issue":"3","key":"5981_CR11","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1007\/s00134-017-4683-6","volume":"43","author":"A Rhodes","year":"2017","unstructured":"Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, Kumar A, Sevransky JE, Sprung CL, Nunnally ME, Rochwerg B, Rubenfeld GD, Angus DC, Annane D, Beale RJ, Bellinghan GJ, Bernard GR, Chiche JD, Coopersmith C, de Backer DP, French CJ, Fujishima S, Gerlach H, Hidalgo JL, Hollenberg SM, Jones AE, Karnad DR, Kleinpell RM, Koh Y, Lisboa TC, Machado FR, Marini JJ, Marshall JC, Mazuski JE, McIntyre LA, McLean AS, Mehta S, Moreno RP, Myburgh J, Navalesi P, Nishida O, Osborn TM, Perner A, Plunkett CM, Ranieri M, Schorr CA, Seckel MA, Seymour CW, Shieh L, Shukri KA, Simpson SQ, Singer M, Thompson BT, Townsend SR, van der Poll T, Vincent JL, Wiersinga WJ, Zimmerman JL, Dellinger RP. Surviving Sepsis campaign: international guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med. 2017;43(3):304\u201377. https:\/\/doi.org\/10.1007\/s00134-017-4683-6.","journal-title":"Intensive Care Med"},{"issue":"21","key":"5981_CR12","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1161\/CIR.0000000000000329","volume":"132","author":"SH Abman","year":"2015","unstructured":"Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Th\u00e9baud B, Fineman JR, Kuehne T, Feinstein JA, Friedberg MK, Earing M, Barst RJ, Keller RL, Kinsella JP, Mullen M, Deterding R, Kulik T, Mallory G, Humpl T, Wessel DL, American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Clinical Cardiology; Council on Cardiovascular Disease in the Young; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Surgery and Anesthesia; and the American Thoracic Society. Pediatric pulmonary hypertension: guidelines from the American Heart Association and American Thoracic Society. Circulation. 2015;132(21):2037\u201399. https:\/\/doi.org\/10.1161\/CIR.0000000000000329.","journal-title":"Circulation."},{"issue":"9","key":"5981_CR13","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1007\/s00431-017-2975-z","volume":"176","author":"N Mendoza-Palomar","year":"2017","unstructured":"Mendoza-Palomar N, Balasch-Carulla M, Gonz\u00e1lez-Di Lauro S, C\u00e9spedes MC, Andreu A, Frick MA, et al. Escherichia coli early-onset sepsis: trends over two decades. Eur J Pediatr. 2017;176(9):1227\u201334. https:\/\/doi.org\/10.1007\/s00431-017-2975-z.","journal-title":"Eur J Pediatr"},{"issue":"12","key":"5981_CR14","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1111\/apa.14889","volume":"108","author":"D Glikman","year":"2019","unstructured":"Glikman D, Curiel N, Glatman-Freedman A, Megged O, Youngster I, Marom R, Lavie K, Smolkin T, Troitzky M, Stein M, the EOS Israeli study group, Stein M, Glikman D, Curiel N, Glatman-Freedman A, Megged O, Eventov-Fiedman S, Keller N, Kriger O, Somekh E, Tasher D, Gottesman G, Guri A, Ashkenazi-Hoffnung L, Ben-Zvi H, Youngster I, Herzlich J, Schindler Y, Marom R, Rubinstein U, Midlij E, Miron D, Damouni R, Kassis I, Nimri-Atrash N, Freiman S, Lavie K, Smolkin T, Melamed R, Troitzky M, Sayag A. Nationwide epidemiology of early-onset sepsis in Israel 2010-2015, time to re-evaluate empiric treatment. Acta Paediatr. 2019;108(12):2192\u20138. https:\/\/doi.org\/10.1111\/apa.14889.","journal-title":"Acta Paediatr"},{"issue":"10","key":"5981_CR15","doi-asserted-by":"publisher","first-page":"e752","DOI":"10.1016\/S2214-109X(16)30148-6","volume":"4","author":"Investigators of the Delhi Neonatal Infection Study (DeNIS) collaboration","year":"2016","unstructured":"Investigators of the Delhi Neonatal Infection Study (DeNIS) collaboration. Characterisation and antimicrobial resistance of sepsis pathogens in neonates born in tertiary care centres in Delhi, India: a cohort study. Lancet Glob Health. 2016;4(10):e752\u201360. https:\/\/doi.org\/10.1016\/S2214-109X(16)30148-6.","journal-title":"Lancet Glob Health"},{"issue":"3","key":"5981_CR16","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.jmii.2013.08.012","volume":"48","author":"MC Lin","year":"2015","unstructured":"Lin MC, Chiu NC, Chi H, Ho CS, Huang FY. Evolving trends of neonatal and childhood bacterial meningitis in northern Taiwan. J Microbiol Immunol Infect. 2015;48(3):296\u2013301. https:\/\/doi.org\/10.1016\/j.jmii.2013.08.012.","journal-title":"J Microbiol Immunol Infect"},{"issue":"1","key":"5981_CR17","first-page":"21","volume":"20","author":"Y Zhu","year":"2017","unstructured":"Zhu Y, Lin Y, Jidong L, Lin X. The effect of prenatal antibiotics on the clinical features and pathogen distribution of neonatal early-onset sepsis. Chin J Perinat Med. 2017;20(1):21\u20136.","journal-title":"Chin J Perinat Med"},{"issue":"3","key":"5981_CR18","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.pedneo.2017.09.001","volume":"59","author":"CC Peng","year":"2018","unstructured":"Peng CC, Chang JH, Lin HY, Cheng PJ, Su BH. Intrauterine inflammation, infection, or both (triple I): a new concept for chorioamnionitis. Pediatr Neonatol. 2018;59(3):231\u20137. https:\/\/doi.org\/10.1016\/j.pedneo.2017.09.001.","journal-title":"Pediatr Neonatol"},{"issue":"11","key":"5981_CR19","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1055\/s-0043-120671","volume":"49","author":"K Warncke","year":"2017","unstructured":"Warncke K, Lickert R, Eitel S, Gloning KP, Bonifacio E, Sedlmeier EM, Becker P, Knoop J, Beyerlein A, Ziegler AG. Thymus growth and fetal immune responses in diabetic pregnancies. Horm Metab Res. 2017;49(11):892\u20138. https:\/\/doi.org\/10.1055\/s-0043-120671.","journal-title":"Horm Metab Res"},{"key":"5981_CR20","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jri.2016.06.007","volume":"117","author":"S Yanai","year":"2016","unstructured":"Yanai S, Tokuhara D, Tachibana D, Saito M, Sakashita Y, Shintaku H, Koyama M. Diabetic pregnancy activates the innate immune response through TLR5 or TLR1\/2 on neonatal monocyte. J Reprod Immunol. 2016;117:17\u201323. https:\/\/doi.org\/10.1016\/j.jri.2016.06.007.","journal-title":"J Reprod Immunol"},{"issue":"3","key":"5981_CR21","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1111\/jam.13468","volume":"123","author":"J Jang","year":"2017","unstructured":"Jang J, Hur HG, Sadowsky MJ, Byappanahalli MN, Yan T, Ishii S. Environmental Escherichia coli: ecology and public health implications-a review. J Appl Microbiol. 2017;123(3):570\u201381. https:\/\/doi.org\/10.1111\/jam.13468.","journal-title":"J Appl Microbiol"},{"issue":"Pt 12","key":"5981_CR22","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1099\/jmm.0.059840-0","volume":"62","author":"T Barichello","year":"2013","unstructured":"Barichello T, Fagundes GD, Generoso JS, Elias SG, Sim\u00f5es LR, Teixeira AL. Pathophysiology of neonatal acute bacterial meningitis. J Med Microbiol. 2013;62(Pt 12):1781\u20139. https:\/\/doi.org\/10.1099\/jmm.0.059840-0.","journal-title":"J Med Microbiol"},{"issue":"3","key":"5981_CR23","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1097\/WCO.0b013e328360415c","volume":"26","author":"ES Kasanmoentalib","year":"2013","unstructured":"Kasanmoentalib ES, Brouwer MC, van de Beek D. Update on bacterial meningitis: epidemiology, trials and genetic association studies. Curr Opin Neurol. 2013;26(3):282\u20138. https:\/\/doi.org\/10.1097\/WCO.0b013e328360415c.","journal-title":"Curr Opin Neurol"},{"issue":"1","key":"5981_CR24","first-page":"62","volume":"10","author":"Y Shen","year":"2015","unstructured":"Shen Y, Wang Y, Kaihu Y, Gao W, Yijun D, Wu D, et al. Study on virulence factors of Escherichia coli isolates in hospitalized newborns. Chin J Evid Based Pediatr. 2015;10(1):62\u20135.","journal-title":"Chin J Evid Based Pediatr"},{"issue":"1","key":"5981_CR25","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1186\/s12866-015-0547-9","volume":"15","author":"DS Wijetunge","year":"2015","unstructured":"Wijetunge DS, Gongati S, DebRoy C, Kim KS, Couraud PO, Romero IA, et al. Characterizing the pathotype of neonatal meningitis causing Escherichia coli (NMEC). BMC Microbiol. 2015;15(1):211. https:\/\/doi.org\/10.1186\/s12866-015-0547-9.","journal-title":"BMC Microbiol"},{"issue":"12","key":"5981_CR26","doi-asserted-by":"publisher","first-page":"e14686","DOI":"10.1097\/MD.0000000000014686","volume":"98","author":"X Li","year":"2019","unstructured":"Li X, Ding X, Shi P, Zhu Y, Huang Y, Li Q, Lu J, Li Z, Zhu L. Clinical features and antimicrobial susceptibility profiles of culture-proven neonatal sepsis in a tertiary children\u2019s hospital, 2013 to 2017. Medicine (Baltimore). 2019;98(12):e14686. https:\/\/doi.org\/10.1097\/MD.0000000000014686.","journal-title":"Medicine (Baltimore)"},{"issue":"7","key":"5981_CR27","doi-asserted-by":"publisher","first-page":"e0219352","DOI":"10.1371\/journal.pone.0219352","volume":"14","author":"BK Cole","year":"2019","unstructured":"Cole BK, Ilikj M, McCloskey CB, Chavez-Bueno S. Antibiotic resistance and molecular characterization of bacteremia Escherichia coli isolates from newborns in the United States. PLoS One. 2019;14(7):e0219352. https:\/\/doi.org\/10.1371\/journal.pone.0219352.","journal-title":"PLoS One"},{"key":"5981_CR28","first-page":"7656752","volume":"2018","author":"DS Lee","year":"2018","unstructured":"Lee DS, Lee SJ, Choe HS. Community-acquired urinary tract infection by Escherichia coli in the era of antibiotic resistance. Biomed Res Int. 2018;2018:7656752.","journal-title":"Biomed Res Int"},{"issue":"9","key":"5981_CR29","doi-asserted-by":"publisher","first-page":"e00816","DOI":"10.1002\/mbo3.816","volume":"8","author":"FB Hertz","year":"2019","unstructured":"Hertz FB, Jans\u00e5ker F, Okon KO, Abdulmumin IS, Onah JO, Ladan J, Knudsen JD. ESBL-production in Escherichia coli and Klebsiella pneumoniae isolates from Nigeria. Microbiologyopen. 2019;8(9):e00816. https:\/\/doi.org\/10.1002\/mbo3.816.","journal-title":"Microbiologyopen."},{"issue":"3","key":"5981_CR30","first-page":"673","volume":"23","author":"LI Haiying","year":"2013","unstructured":"Haiying LI, Baowei DONG, Yahong BAI. Drug resistance of Escherichia coli from 2008 to 2010. Chin J Nosocomiol. 2013;23(3):673\u20135.","journal-title":"Chin J Nosocomiol"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-021-05981-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12879-021-05981-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-021-05981-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T13:06:42Z","timestamp":1616504802000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-021-05981-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,23]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["5981"],"URL":"https:\/\/doi.org\/10.1186\/s12879-021-05981-4","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,23]]},"assertion":[{"value":"19 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Women and Children\u2019s Hospital, School of Medicine, Xiamen University. Oral consent was obtained from participants\u2019 parents, and demographics (omitted the participants and their mother\u2019s name) and clinical records were collected according to the verbal consent procedure. The verbal consent procedure was approved by the Institutional Review Board at our hospital.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"295"}}