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However, limited data are available regarding the comparison of clinical outcomes between patients receiving initial teicoplanin and those receiving \u03b2-lactam antibiotics for MSSA bacteremia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Eighty-four adults with MSSA bacteremia were included: initial teicoplanin treatment group (<jats:italic>n<\/jats:italic>\u2009=\u200928) and \u03b2-lactam treatment group (<jats:italic>n<\/jats:italic>\u2009=\u200956). The two groups were further stratified based on propensity score matching according to the outcome analysis using a logistic regression model. We investigated the clinical outcomes between the groups before and after propensity score matching after treatment completion.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Pittsburgh bacteremia score\u2009\u2265\u20094 (odds ratio, 60.6; 95%CI, 7.4\u2013496.8) was an independent risk factor for unfavorable outcome. After propensity score matching, the initial teicoplanin treatment group and the \u03b2-lactam treatment group consisted of 28 patients each. No statistically significant differences were observed in the proportions of patients with favorable outcomes and 30-day overall mortality rates between the groups before and after propensity score matching after the completion of teicoplanin or \u03b2-lactam treatment. The Kaplan-Meier 30-day survival curve also showed no significant difference between the patients receiving initial teicoplanin treatment and those receiving \u03b2-lactam treatment before and after matching (hazard ratio, 1.84, 95%CI, 0.60\u20135.64; and 3.12, 95%CI, 0.98\u20139.99, respectively).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>There were no significant difference in clinical outcomes between initial teicoplanin treatment and \u03b2-lactam treatment among patients with MSSA bacteremia. Pittsburgh bacteremia score\u2009\u2265\u20094 was a significant risk factor for mortality.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-021-06111-w","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T19:02:43Z","timestamp":1620846163000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Teicoplanin versus \u03b2-lactam for febrile patients with Staphylococcus-like bacteremia: focus on methicillin-susceptible Staphylococcus aureus bacteremia"],"prefix":"10.1186","volume":"21","author":[{"given":"Ching-Yen","family":"Tsai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Hsiang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I-Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"issue":"5","key":"6111_CR1","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1378\/chest.123.5.1615","volume":"123","author":"J Valles","year":"2003","unstructured":"Valles J, Rello J, Ochagavia A, Garnacho J, Alcala MA. 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The raw data mentioned in the methods granted permission from the Institutional Review Board of Chang Gung Memorial Hospital and the data used in this study was anonymised before its use.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"437"}}