{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:07:38Z","timestamp":1793210858225,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>HPV and <jats:italic>C.trachomatis<\/jats:italic> are the most prevalent, viral and bacterial STI worldwide. Both commonly have an asymptomatic development and can evolve into a persistent infection which, added to coinfections, may be important cofactors for the oncogenic transformation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>Evaluate the prevalence of oral and genital HPV and <jats:italic>C.trachomatis<\/jats:italic> infection in women with normal and abnormal cervical cytology.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Study design<\/jats:title>\n                <jats:p>The cross-sectional study included 200 swabs, 100 oral and 100 cervical from 50 women with normal and 50 with abnormal cervical cytology. HPV and <jats:italic>C.trachomatis<\/jats:italic> infections were detected using PCR with specific primers.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>HPV DNA was detected in 27% (<jats:italic>n<\/jats:italic>\u2009=\u200927\/100) of women with normal and abnormal cytology. Out of 100 genital samples we detected HPV DNA in 18% (<jats:italic>n<\/jats:italic>\u2009=\u200918\/100) and 14% (<jats:italic>n<\/jats:italic>\u2009=\u200914\/100) out of 100 oral samples. HPV genotypes detected were genotype 6 of low-risk and 16, 31, 52, 58 and 16\u201331 coinfection of high-risk. <jats:italic>C.trachomatis<\/jats:italic> DNA was detected in 49% (<jats:italic>n<\/jats:italic>\u2009=\u200949\/100) of patients. Out of 100 genital samples we detected <jats:italic>C.trachomatis<\/jats:italic> in 35% (<jats:italic>n<\/jats:italic>\u2009=\u200935\/100) and 31% (<jats:italic>n<\/jats:italic>\u2009=\u200931) out of 100 oral samples. There is statistically significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) between cytology and HPV and <jats:italic>C.trachomatis<\/jats:italic> infection but there is no statistically significant between cytology and the other characteristics.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Since the histology of oral mucosa resembles that of the uterine cervix, we can anticipate the presence of HPV and other STI which are detected in different lesions of genital areas and the oral mucosa. Therefore, is important <jats:italic>C.trachomatis<\/jats:italic> detection and specific treatment in asymptomatic women because this infection may increase the risk of HPV persistence and coinfection induces a pro-inflammatory environment that may promote the carcinogenesis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-021-06118-3","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T09:05:37Z","timestamp":1620205537000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Human papillomavirus and Chlamydia trachomatis in oral and genital mucosa of women with normal and abnormal cervical cytology"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0839-6324","authenticated-orcid":false,"given":"J. P.","family":"Mosmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Zayas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. X.","family":"Kiguen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. F.","family":"Venezuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Rosato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. G.","family":"Cuffini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,5]]},"reference":[{"issue":"1","key":"6118_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.virol.2009.06.001","volume":"392","author":"H Zur Hausen","year":"2009","unstructured":"Zur Hausen H. The search for infectious causes of human cancers: where and why. Virology. 2009;392(1):1\u201310. https:\/\/doi.org\/10.1016\/j.virol.2009.06.001.","journal-title":"Virology"},{"issue":"6","key":"6118_CR2","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.ajog.2016.07.003","volume":"215","author":"DR Nonato","year":"2016","unstructured":"Nonato DR, Alves RR, Ribeiro AA, Saddi VA, Segati KD, Almeida KP, et al. Prevalence and factors associated with coinfection of human papillomavirus and Chlamydia trachomatis in adolescents and young women. Am J Obstetr Gynecol. 2016;215(6):753\u2013e751 753 e759.","journal-title":"Am J Obstetr Gynecol"},{"issue":"1","key":"6118_CR3","doi-asserted-by":"publisher","first-page":"1632129","DOI":"10.1080\/20002297.2019.1632129","volume":"11","author":"JP Mosmann","year":"2019","unstructured":"Mosmann JP, Talavera AD, Criscuolo MI, Venezuela RF, Kiguen AX, Panico R, et al. Sexually transmitted infections in oral cavity lesions: human papillomavirus, chlamydia trachomatis, and herpes simplex virus. J Oral Microbiol. 2019;11(1):1632129. https:\/\/doi.org\/10.1080\/20002297.2019.1632129.","journal-title":"J Oral Microbiol"},{"issue":"6","key":"6118_CR4","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1007\/s00404-016-4167-x","volume":"294","author":"S Bianchi","year":"2016","unstructured":"Bianchi S, Boveri S, Igidbashian S, Amendola A, Urbinati AM, Frati ER, et al. Chlamydia trachomatis infection and HPV\/chlamydia trachomatis co-infection among HPV-vaccinated young women at the beginning of their sexual activity. Arch Gynecol Obstet. 2016;294(6):1227\u201333. https:\/\/doi.org\/10.1007\/s00404-016-4167-x.","journal-title":"Arch Gynecol Obstet"},{"issue":"2","key":"6118_CR5","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1093\/infdis\/jiy497","volume":"219","author":"Y Ji","year":"2019","unstructured":"Ji Y, Ma XX, Li Z, Peppelenbosch MP, Ma Z, Pan Q. The burden of human papillomavirus and chlamydia trachomatis Coinfection in women: a large cohort study in Inner Mongolia, China. J Infect Dis. 2019;219(2):206\u201314. https:\/\/doi.org\/10.1093\/infdis\/jiy497.","journal-title":"J Infect Dis"},{"issue":"Suppl 1","key":"6118_CR6","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/eos.12538","volume":"126","author":"S Syrjanen","year":"2018","unstructured":"Syrjanen S. Oral manifestations of human papillomavirus infections. Eur J Oral Sci. 2018;126(Suppl 1):49\u201366. https:\/\/doi.org\/10.1111\/eos.12538.","journal-title":"Eur J Oral Sci"},{"issue":"2","key":"6118_CR7","doi-asserted-by":"publisher","first-page":"e8","DOI":"10.1016\/j.oraloncology.2014.11.015","volume":"51","author":"WD Jenkins","year":"2015","unstructured":"Jenkins WD, LeVault K, Sutcliffe S. Chlamydia trachomatis infection: possible cofactor for oropharyngeal cancer development? Oral Oncol. 2015;51(2):e8\u20139. https:\/\/doi.org\/10.1016\/j.oraloncology.2014.11.015.","journal-title":"Oral Oncol"},{"issue":"6","key":"6118_CR8","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1007\/s00404-019-05135-7","volume":"299","author":"TK Eggersmann","year":"2019","unstructured":"Eggersmann TK, Sharaf K, Baumeister P, Thaler C, Dannecker CJ, Jeschke U, et al. Prevalence of oral HPV infection in cervical HPV positive women and their sexual partners. Arch Gynecol Obstet. 2019;299(6):1659\u201365. https:\/\/doi.org\/10.1007\/s00404-019-05135-7.","journal-title":"Arch Gynecol Obstet"},{"issue":"5","key":"6118_CR9","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1111\/j.1442-2042.2006.01733.x","volume":"14","author":"R Hamasuna","year":"2007","unstructured":"Hamasuna R, Hoshina S, Imai H, Jensen JS, Osada Y. Usefulness of oral wash specimens for detecting chlamydia trachomatis from high-risk groups in Japan. Int J Urol. 2007;14(5):473\u20135. https:\/\/doi.org\/10.1111\/j.1442-2042.2006.01733.x.","journal-title":"Int J Urol"},{"issue":"3","key":"6118_CR10","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1136\/sextrans-2014-051633","volume":"91","author":"MS van Rooijen","year":"2015","unstructured":"van Rooijen MS, van der Loeff MF, Morre SA, van Dam AP, Speksnijder AG, de Vries HJ. Spontaneous pharyngeal chlamydia trachomatis RNA clearance. A cross-sectional study followed by a cohort study of untreated STI clinic patients in Amsterdam, the Netherlands. Sex Transm Infect. 2015;91(3):157\u201364. https:\/\/doi.org\/10.1136\/sextrans-2014-051633.","journal-title":"Sex Transm Infect"},{"key":"6118_CR11","first-page":"228","volume":"3","author":"RF Venezuela","year":"2013","unstructured":"Venezuela RF, Talavera AD, Frutos MC, Kiguen AX, Monetti MS, Sollazo M, et al. Human papillomavirus (HPV) in oral cavity lesions: comparison with other oral cancer risk factors. J Microbiol Res. 2013;3:228\u201333.","journal-title":"J Microbiol Res"},{"issue":"3","key":"6118_CR12","doi-asserted-by":"publisher","first-page":"e1008376","DOI":"10.1371\/journal.ppat.1008376","volume":"16","author":"M Usyk","year":"2020","unstructured":"Usyk M, Zolnik CP, Castle PE, Porras C, Herrero R, Gradissimo A, et al. Cervicovaginal microbiome and natural history of HPV in a longitudinal study. PLoS Pathog. 2020;16(3):e1008376. https:\/\/doi.org\/10.1371\/journal.ppat.1008376.","journal-title":"PLoS Pathog"},{"issue":"5","key":"6118_CR13","first-page":"1118","volume":"77","author":"K Biondi","year":"1998","unstructured":"Biondi K, Belloni S, Velasco M, Robledo G, Gallardo Femopase F, Lanfranchi H. Correlation between oral precancer and cancer and tobacco. J Dental Res. 1998;77(5):1118.","journal-title":"J Dental Res"},{"key":"6118_CR14","first-page":"209","volume":"7","author":"MM Manos","year":"1989","unstructured":"Manos MM. The use of polymerase chain reaction amplification for the detection of genital human papillomavirus. Cancer Cell. 1989;7:209\u201314.","journal-title":"Cancer Cell"},{"issue":"5","key":"6118_CR15","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1093\/infdis\/170.5.1077","volume":"170","author":"HU Bernard","year":"1994","unstructured":"Bernard HU, Chan SY, Manos MM, Ong CK, Villa LL, Delius H, et al. Identification and assessment of known and novel human papillomaviruses by polymerase chain reaction amplification, restriction fragment length polymorphisms, nucleotide sequence, and phylogenetic algorithms. J Infect Dis. 1994;170(5):1077\u201385. https:\/\/doi.org\/10.1093\/infdis\/170.5.1077.","journal-title":"J Infect Dis"},{"issue":"Suppl 5","key":"6118_CR16","doi-asserted-by":"publisher","first-page":"F55","DOI":"10.1016\/j.vaccine.2012.06.083","volume":"30","author":"J Doorbar","year":"2012","unstructured":"Doorbar J, Quint W, Banks L, Bravo IG, Stoler M, Broker TR, et al. The biology and life-cycle of human papillomaviruses. Vaccine. 2012;30(Suppl 5):F55\u201370. https:\/\/doi.org\/10.1016\/j.vaccine.2012.06.083.","journal-title":"Vaccine"},{"issue":"5","key":"6118_CR17","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1128\/JCM.31.5.1060-1065.1993","volume":"31","author":"J Lan","year":"1993","unstructured":"Lan J, Walboomers JM, Roosendaal R, van Doornum GJ, MacLaren DM, Meijer CJ, et al. Direct detection and genotyping of chlamydia trachomatis in cervical scrapes by using polymerase chain reaction and restriction fragment length polymorphism analysis. J Clin Microbiol. 1993;31(5):1060\u20135. https:\/\/doi.org\/10.1128\/JCM.31.5.1060-1065.1993.","journal-title":"J Clin Microbiol"},{"issue":"2","key":"6118_CR18","doi-asserted-by":"publisher","first-page":"62","DOI":"10.5603\/GP.a2018.0011","volume":"89","author":"F Beyazit","year":"2018","unstructured":"Beyazit F, Silan F, Gencer M, Aydin B, Paksoy B, Unsal MA, et al. The prevelance of human papillomavirus (HPV) genotypes detected by PCR in women with normal and abnormal cervico-vaginal cytology. Ginekol Pol. 2018;89(2):62\u20137. https:\/\/doi.org\/10.5603\/GP.a2018.0011.","journal-title":"Ginekol Pol"},{"issue":"10","key":"6118_CR19","doi-asserted-by":"publisher","first-page":"e0205574","DOI":"10.1371\/journal.pone.0205574","volume":"13","author":"G Cossellu","year":"2018","unstructured":"Cossellu G, Fedele L, Badaoui B, Angiero F, Farronato G, Monti E, et al. Prevalence and concordance of oral and genital HPV in women positive for cervical HPV infection and in their sexual stable partners: an Italian screening study. PLoS One. 2018;13(10):e0205574. https:\/\/doi.org\/10.1371\/journal.pone.0205574.","journal-title":"PLoS One"},{"issue":"1","key":"6118_CR20","first-page":"34","volume":"41","author":"M Di Pietro","year":"2018","unstructured":"Di Pietro M, Filardo S, Porpora MG, Recine N, Latino MA, Sessa R. HPV\/chlamydia trachomatis co-infection: metagenomic analysis of cervical microbiota in asymptomatic women. New Microbiol. 2018;41(1):34\u201341.","journal-title":"New Microbiol"},{"issue":"6","key":"6118_CR21","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1097\/OLQ.0b013e3181c94a3b","volume":"37","author":"AR Kreimer","year":"2010","unstructured":"Kreimer AR, Bhatia RK, Messeguer AL, Gonzalez P, Herrero R, Giuliano AR. Oral human papillomavirus in healthy individuals: a systematic review of the literature. Sex Transm Dis. 2010;37(6):386\u201391. https:\/\/doi.org\/10.1097\/OLQ.0b013e3181c94a3b.","journal-title":"Sex Transm Dis"},{"issue":"6","key":"6118_CR22","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1002\/jmv.24746","volume":"89","author":"G Ciccarese","year":"2017","unstructured":"Ciccarese G, Herzum A, Rebora A, Drago F. Prevalence of genital, oral, and anal HPV infection among STI patients in Italy. J Med Virol. 2017;89(6):1121\u20134. https:\/\/doi.org\/10.1002\/jmv.24746.","journal-title":"J Med Virol"},{"key":"6118_CR23","first-page":"1","volume":"3","author":"MI Criscuolo","year":"2018","unstructured":"Criscuolo MI, Belardinelli P, Morelatto R, Mosmann JP, Venezuela RF, Kiguen AX, et al. Prevalence of oral human papillomavirus (HPV) in the adult population of C\u00f3rdoba, Argentina. Transl Res Oral Oncol. 2018;3:1\u20138.","journal-title":"Transl Res Oral Oncol"},{"key":"6118_CR24","doi-asserted-by":"publisher","first-page":"5758387","DOI":"10.1155\/2016\/5758387","volume":"2016","author":"PA Chan","year":"2016","unstructured":"Chan PA, Robinette A, Montgomery M, Almonte A, Cu-Uvin S, Lonks JR, et al. Extragenital infections caused by chlamydia trachomatis and Neisseria gonorrhoeae: a review of the literature. Infect Dis Obstet Gynecol. 2016;2016:5758387.","journal-title":"Infect Dis Obstet Gynecol"},{"key":"6118_CR25","doi-asserted-by":"publisher","unstructured":"Costa-Lira E, Jacinto A, Silva LM, Napole\u00e3o P, Barbosa-Filho R, Cruz G, Astolfi-Filho S, Borborema-Santos CM. Prevalence of human papillomavirus, Chlamydia trachomatis, and Trichomonas vaginalis infections in Amazonian women with normal and abnormal cytology. Genet Mol Res: GMR. 2017;16(2):10.4238\/gmr16029626. https:\/\/doi.org\/10.4238\/gmr16029626.","DOI":"10.4238\/gmr16029626"},{"issue":"1","key":"6118_CR26","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1186\/s12889-017-4181-3","volume":"17","author":"A Adenis","year":"2017","unstructured":"Adenis A, Dufit V, Douine M, Najioullah F, Molinie V, Catherine D, et al. The singular epidemiology of HPV infection among French Guianese women with normal cytology. BMC Public Health. 2017;17(1):279. https:\/\/doi.org\/10.1186\/s12889-017-4181-3.","journal-title":"BMC Public Health"},{"key":"6118_CR27","doi-asserted-by":"publisher","first-page":"9092565","DOI":"10.1155\/2019\/9092565","volume":"2019","author":"F Ssedyabane","year":"2019","unstructured":"Ssedyabane F, Amnia DA, Mayanja R, Omonigho A, Ssuuna C, Najjuma JN, et al. HPV-chlamydial Coinfection, prevalence, and association with cervical intraepithelial lesions: a pilot study at Mbarara regional referral hospital. J Cancer Epidemiol. 2019;2019:9092565.","journal-title":"J Cancer Epidemiol"},{"issue":"1","key":"6118_CR28","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1590\/S0036-46652012000100003","volume":"54","author":"RF Venezuela","year":"2012","unstructured":"Venezuela RF, Kiguen AX, Frutos MC, Cuffini CG. Circulation of human papillomavirus (HPV) genotypes in women from Cordoba, Argentina, with squamous intraepithelial lesions. Rev Inst Med Trop Sao Paulo. 2012;54(1):11\u20136. https:\/\/doi.org\/10.1590\/S0036-46652012000100003.","journal-title":"Rev Inst Med Trop Sao Paulo"},{"issue":"3","key":"6118_CR29","doi-asserted-by":"publisher","first-page":"e425","DOI":"10.4317\/medoral.23462","volume":"25","author":"MI Criscuolo","year":"2020","unstructured":"Criscuolo MI, Morelatto RA, Belardinelli PA, Mosmann JM, Cuffini C, Lopez de Blanc SA. Oral Human Papillomavirus: a multisite infection. Med Oral Patol Oral Cir Bucal. 2020;25(3):e425\u201330.","journal-title":"Med Oral Patol Oral Cir Bucal"},{"issue":"1","key":"6118_CR30","doi-asserted-by":"publisher","first-page":"57","DOI":"10.4103\/ijstd.IJSTD_9_19","volume":"40","author":"N Madaan","year":"2019","unstructured":"Madaan N, Pandhi D, Sharma V, Bhattacharya SN, Guleria K, Mishra K, et al. Association of abnormal cervical cytology with coinfection of human papillomavirus and chlamydia trachomatis. Indian J Sex Trans Dis AIDS. 2019;40(1):57\u201363. https:\/\/doi.org\/10.4103\/ijstd.IJSTD_9_19.","journal-title":"Indian J Sex Trans Dis AIDS"},{"issue":"1","key":"6118_CR31","first-page":"21","volume":"31","author":"GB Jorda","year":"2018","unstructured":"Jorda GB, Hanke SE, Ramos-Rincon JM, Mosmann J, Lopez ML, Entrocassi AC, et al. Prevalence and phylogenetic analysis of chlamydia trachomatis in a population of women in Posadas, Misiones. Rev Esp Quimioter. 2018;31(1):21\u20136.","journal-title":"Rev Esp Quimioter"},{"issue":"5","key":"6118_CR32","doi-asserted-by":"publisher","first-page":"e0217245","DOI":"10.1371\/journal.pone.0217245","volume":"14","author":"AX Kiguen","year":"2019","unstructured":"Kiguen AX, Marrama M, Ruiz S, Estofan P, Venezuela RF, Mosmann JP, et al. Prevalence, risk factors and molecular characterization of chlamydia trachomatis in pregnant women from Cordoba, Argentina: a prospective study. PLoS One. 2019;14(5):e0217245. https:\/\/doi.org\/10.1371\/journal.pone.0217245.","journal-title":"PLoS One"},{"issue":"2","key":"6118_CR33","doi-asserted-by":"publisher","first-page":"91","DOI":"10.4103\/0975-962X.155877","volume":"6","author":"S Gupta","year":"2015","unstructured":"Gupta S, Gupta S. Role of human papillomavirus in oral squamous cell carcinoma and oral potentially malignant disorders: a review of the literature. Indian J Dent. 2015;6(2):91\u20138. https:\/\/doi.org\/10.4103\/0975-962X.155877.","journal-title":"Indian J Dent"},{"issue":"3","key":"6118_CR34","doi-asserted-by":"publisher","first-page":"209","DOI":"10.11138\/orl\/2017.10.3.209","volume":"10","author":"V Candotto","year":"2017","unstructured":"Candotto V, Lauritano D, Nardone M, Baggi L, Arcuri C, Gatto R, et al. HPV infection in the oral cavity: epidemiology, clinical manifestations and relationship with oral cancer. Oral Implantol. 2017;10(3):209\u201320. https:\/\/doi.org\/10.11138\/orl\/2017.10.3.209.","journal-title":"Oral Implantol"},{"issue":"1","key":"6118_CR35","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s13027-016-0111-8","volume":"12","author":"R Robial","year":"2017","unstructured":"Robial R, Longatto-Filho A, Roteli-Martins CM, Silveira MF, Stauffert D, Ribeiro GG, et al. Frequency of chlamydia trachomatis infection in cervical intraepithelial lesions and the status of cytological p16\/Ki-67 dual-staining. Infect Agents Cancer. 2017;12(1):3. https:\/\/doi.org\/10.1186\/s13027-016-0111-8.","journal-title":"Infect Agents Cancer"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-021-06118-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12879-021-06118-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-021-06118-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T09:07:45Z","timestamp":1620205665000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-021-06118-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,5]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["6118"],"URL":"https:\/\/doi.org\/10.1186\/s12879-021-06118-3","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,5]]},"assertion":[{"value":"1 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Committee of Ethics, National Hospital of Clinics- Argentina (RePIS2548) according to the ethical principles stated in the declaration of Helsinki. All patients included in the study, signed an informed consent form.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All data of this study are anonymous and we do not use patient name to publish.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"422"}}