{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:50:00Z","timestamp":1788537000644,"version":"build-2803163510"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Critically ill patients frequently suffer from vitamin C deficiency. Previous studies showed that high doses of vitamin C administration had conflicting results on clinical outcomes in patients with severe sepsis, burns, and trauma. Because of the high incidence and morbidity\/mortality with severe pneumonia, we aimed to investigate the effect of administration of high dose vitamin C in critically ill patients with severe pneumonia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eighty critically ill patients with pneumonia were enrolled in this randomized double-blinded clinical trial. Patients with a CURB-65 score\u2009&gt;\u20093, one major criterion, or\u2009\u2265\u20093 minor criteria were considered as severe pneumonia. Patients were randomly assigned to intervention or placebo groups receiving standard treatment plus 60\u2009mg\/kg\/day vitamin C as a continuous infusion or normal saline in the same volume correspondingly for 96\u2009h. Serum levels of vitamin C were noted at baseline and 48\u2009h after vitamin C administration. Duration of mechanical ventilation, ICU length of stay, PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      , and mortality rate were noted for all patients till the 28th day. Any complications related to the vitamin C administration were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Duration of mechanical ventilation and vasopressor use were significantly lower in the intervention group (\n                      <jats:italic>p<\/jats:italic>\n                      : &lt;\u20090.001 and 0.003, respectively). Baseline levels of vitamin C in both groups did not have a significant difference but its levels increased in the intervention group and decreased in the control group during the study period. Mortality rate insignificantly decreased in the intervention group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.17). Three patients showed hypotension and tachycardia during the administration of vitamin C which was self-limited with decreasing the dose of vitamin C.\n                    <\/jats:p>\n                    <jats:p>Our results showed that the intravenous administration of a relatively high dose of vitamin C to critically ill patients with severe pneumonia was safe and could decrease the inflammation, duration of mechanical ventilation, and vasopressor use without any significant effect on mortality.<\/jats:p>\n                    <jats:p>Trial registration: IRCT registration number: IRCT20190312043030N1, Registration date: 2019-08-26, Seied Hadi Saghaleini.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12879-021-06288-0","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T08:02:42Z","timestamp":1624953762000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Effect of Vitamin C on mortality of critically ill patients with severe pneumonia in intensive care unit: a preliminary study"],"prefix":"10.1186","volume":"21","author":[{"given":"Ata","family":"Mahmoodpoor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Shadvar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarvin","family":"Sanaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mir Reza","family":"Hadipoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Ata","family":"Pourmoghaddam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4996-4372","authenticated-orcid":false,"given":"Seied Hadi","family":"Saghaleini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"issue":"6","key":"6288_CR1","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1111\/odi.12446","volume":"22","author":"SJ Padayatty","year":"2016","unstructured":"Padayatty SJ, Levine M. 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The informed consent and ethics approval was approved by Regional Research Ethics Committee, Tabriz University of Medical Sciences, by Approval ID: IR.TBZMED.REC.1398.482 and Approval Date: 2019-07-29.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"616"}}