{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T06:21:34Z","timestamp":1789798894233,"version":"4.0.1"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81804030"],"award-info":[{"award-number":["81804030"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Infection <jats:italic>of Helcococcus kunzii<\/jats:italic>(<jats:italic>H<\/jats:italic>. <jats:italic>kunzii<\/jats:italic>) from diabetic foot wound is rarely reported. This case report describes the infection <jats:italic>of H.kunzii<\/jats:italic> and highlights the therapeutic effect on <jats:italic>H.kunzii<\/jats:italic> from a diabetic foot wound.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>In this study, one <jats:italic>H<\/jats:italic>. <jats:italic>kunzii<\/jats:italic> strain was isolated from a patient with diabetic foot, which was confirmed by 16S rRNA gene analysis and MALDI-TOF-MS. It is the first Chinese case of <jats:italic>H. kunzii<\/jats:italic> in a patient with diabetic foot. As a result of the lack of antibiotic sensitivity data and multiple comorbidities, antibiotics were used cautiously, and those administered during the first 3\u2009months were ineffective. Then, vacuum sealing drainage (VSD) was applied during hospitalization; no antibiotics were used and the wound healed well.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>VSD alone may be more effective in treating diabetic feet infected with <jats:italic>H. kunzii<\/jats:italic>, which may provide reference for clinical treatment of <jats:italic>H. kunzii<\/jats:italic> infection from diabetic foot.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-021-06309-y","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T08:03:03Z","timestamp":1626768183000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["First Chinese case report of Helcococcus kunzii in a patient with diabetic foot"],"prefix":"10.1186","volume":"21","author":[{"given":"Ruiying","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linzhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6353-8188","authenticated-orcid":false,"given":"Xiangsheng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,20]]},"reference":[{"issue":"11","key":"6309_CR1","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.1128\/jcm.35.11.2759-2761.1997","volume":"35","author":"J Haas","year":"1997","unstructured":"Haas J, Jernick SL, Scardina RJ, Teruya J, Caliendo AM, Ruoff KL. Colonization of skin by Helcococcus kunzii. J Clin Microbiol. 1997;35(11):2759\u201361. https:\/\/doi.org\/10.1128\/jcm.35.11.2759-2761.1997.","journal-title":"J Clin Microbiol"},{"issue":"Pt 7","key":"6309_CR2","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1099\/jmm.0.2008\/000471-0","volume":"57","author":"N Lema\u00eetre","year":"2008","unstructured":"Lema\u00eetre N, Huvent D, Lo\u00efez C, Wallet F, Courcol RJ. Isolation of Helcococcus kunzii from plantar phlegmon in a vascular patient. J Med Microbiol. 2008;57(Pt 7):907\u20138. https:\/\/doi.org\/10.1099\/jmm.0.2008\/000471-0.","journal-title":"J Med Microbiol"},{"issue":"3","key":"6309_CR3","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1099\/00207713-43-3-425","volume":"43","author":"MD Collins","year":"1993","unstructured":"Collins MD, Facklam RR, Rodrigues UM, Ruoff KL. Phylogenetic analysis of some Aerococcus-like organisms from clinical sources: description of Helcococcus kunzii gen. Nov., sp. nov. 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Int J Syst Evol Microbiol. 2004;54(Pt 5):1557\u201360. https:\/\/doi.org\/10.1099\/ijs.0.63077-0.","journal-title":"Int J Syst Evol Microbiol"},{"key":"6309_CR6","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1099\/00207713-49-4-1429","volume":"49 Pt 4","author":"MD Collins","year":"1999","unstructured":"Collins MD, Falsen E, Foster G, Monasterio LR, Dominguez L, Fernandez-Garazabal JF. Helcococcus ovis sp. nov., a gram-positive organism from sheep. Int J Syst Bacteriol. 1999;49 Pt 4:1429\u201332.","journal-title":"Int J Syst Bacteriol"},{"issue":"3","key":"6309_CR7","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1128\/JCM.03076-13","volume":"52","author":"SK Chow","year":"2014","unstructured":"Chow SK, Clarridge JE 3rd. Identification and clinical significance of Helcococcus species, with description of Helcococcus seattlensis sp. nov. from a patient with urosepsis. J Clin Microbiol. 2014;52(3):854\u20138. https:\/\/doi.org\/10.1128\/JCM.03076-13.","journal-title":"J Clin Microbiol"},{"issue":"6","key":"6309_CR8","doi-asserted-by":"publisher","first-page":"484","DOI":"10.3343\/alm.2014.34.6.484","volume":"34","author":"JH Park","year":"2014","unstructured":"Park JH, Woo BM, Hong SK, Kim EC. First Korean case of Helcococcus kunzii bacteremia in a patient with diabetes. Ann Lab Med. 2014;34(6):484\u20136. https:\/\/doi.org\/10.3343\/alm.2014.34.6.484.","journal-title":"Ann Lab Med"},{"issue":"2","key":"6309_CR9","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1128\/JCM.01244-11","volume":"50","author":"C P\u00e9rez-Jorge","year":"2012","unstructured":"P\u00e9rez-Jorge C, Cordero J, Marin M, Esteban J. Prosthetic joint infection caused by Helcococcus kunzii. J Clin Microbiol. 2012;50(2):528\u201330. https:\/\/doi.org\/10.1128\/JCM.01244-11.","journal-title":"J Clin Microbiol"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-021-06309-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12879-021-06309-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-021-06309-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T08:06:42Z","timestamp":1626768402000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-021-06309-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,20]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["6309"],"URL":"https:\/\/doi.org\/10.1186\/s12879-021-06309-y","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,20]]},"assertion":[{"value":"16 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethics approval was not required and the patient gave her written consent to participate.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The patient gave both oral and written informed consent to the publication of his case (including his personal and clinical details). The data presented in this case report do not allow identification of the patient.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"695"}}