{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T01:14:13Z","timestamp":1782177253981,"version":"3.54.5"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The management of non-fermentative gram-negative bloodstream infection (NFGN-BSI) offers numerous challenges. In this study the aim is to analyse a large cohort of patients with NFGN-BSI recruited in the northern Italy to describe epidemiology, etiological and susceptibility pattern, therapeutic management and outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multicentre retrospective cohort study of patients hospitalised at three large teaching hospitals in northern Italy in a fourth year period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      355 BSI episodes were analyzed, due to\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      (72.7%),\n                      <jats:italic>A. baumannii<\/jats:italic>\n                      (16.6%), and\n                      <jats:italic>Stenotrophomonas maltophilia<\/jats:italic>\n                      (10.7%). Overall, 21.4% of isolates were defined as DTR, highest rate among\n                      <jats:italic>A. baumannii<\/jats:italic>\n                      (64.4%). All-cause 30-day mortality rate was 17.5%. Rates of XDR or DTR\n                      <jats:italic>A. baumannii<\/jats:italic>\n                      isolation were significantly higher in non-surviving patients. Independent risk factors for 30-day mortality were: age (HR 1.03, 95%CI 1.00\u20131.04, p\u2009=\u20090.003), septic shock (HR 2.84, 95%CI 1.67\u20134.82, p\u2009&lt;\u20090.001) and BSI due to\n                      <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                      (HR 2.23, 95%CI 1.27\u20133.94, p\u2009=\u20090.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The overall prevalence of DTR was high in the NFGN BSI cohort analyzied, mainly among\n                      <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                      episodes (64.4%).\n                      <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                      is showed to be an independent predictor of mortality. These evidences marked the urgent need of new therapeutic options against this pathogen.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:italic>Trial registration number:<\/jats:italic>\n                      79\/2017\/O\/OssN. Approved: March14th, 2017.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12879-021-06496-8","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T05:03:03Z","timestamp":1628744583000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Non-fermentative gram-negative bloodstream infection in northern Italy: a multicenter cohort study"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2687-4235","authenticated-orcid":false,"given":"Renato","family":"Pascale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Corcione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Bussini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Pancaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele Roberto","family":"Giacobbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Ambretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Lupia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Marchese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco Giuseppe","family":"De Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Bassetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Viscoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Bartoletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddalena","family":"Giannella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Viale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,12]]},"reference":[{"key":"6496_CR1","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1111\/j.1469-0691.2007.01681.x","volume":"13","author":"N Mesaros","year":"2007","unstructured":"Mesaros N, Nordmann P, Plesiat P, Roussel-Delvallez M, Van Eldere J, Glupczynski Y, et al. 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