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Accordingly, the current study sought to examine the spatiotemporal trends associated with this potentially severe protozoan infection.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Overall, 4509 cases of infection from January 2008 to December 2017 were geo-referenced to a Census Small Area (SA), with an ensemble of geo-statistical approaches including seasonal decomposition, Local Moran\u2019s <jats:italic>I<\/jats:italic>, and space\u2013time scanning used to elucidate spatiotemporal patterns of infection.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>One or more confirmed cases were notified in 3413 of 18,641 Census SAs (18.3%), with highest case numbers occurring in the 0\u20135-year range (n\u2009=\u20092672, 59.3%). Sporadic cases were more likely male (OR 1.4) and rural (OR 2.4), with outbreak-related cases more likely female (OR 1.4) and urban (OR 1.5). Altogether, 55 space\u2013time clusters (\u2265\u200910 confirmed cases) of sporadic infection were detected, with three \u201chigh recurrence\u201d regions identified; no large urban conurbations were present within recurrent clusters.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Spatiotemporal analysis represents an important indicator of infection patterns, enabling targeted epidemiological intervention and surveillance. Presented results may also be used to further understand the sources, pathways, receptors, and thus mechanisms of cryptosporidiosis in Ireland.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-021-06598-3","type":"journal-article","created":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T09:02:52Z","timestamp":1630141372000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Spatiotemporal epidemiology of cryptosporidiosis in the Republic of Ireland, 2008\u20132017: development of a space\u2013time \u201ccluster recurrence\u201d index"],"prefix":"10.1186","volume":"21","author":[{"given":"M.","family":"Boudou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Cleary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"\u00d3hAiseadha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Garvey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"McKeown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"O\u2019Dwyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Hynds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,28]]},"reference":[{"issue":"4","key":"6598_CR1","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/S0016-5085(76)80503-3","volume":"70","author":"FA Nime","year":"1976","unstructured":"Nime FA, Burek JD, Page DL, Holscher MA, Yardley JH. 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The employed anonymisation protocol is considered equivalent to irreversible anonymisation, appropriate for release to academic researchers, as approved by the Irish Data Protection Commissioner, and as such, informed consent was considered unnecessary, as set out in the Research Ethical Approval documents provided by the Royal College of Physicians of Ireland, comprising both data usage and epidemiological methodologies employed. 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