{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T23:50:47Z","timestamp":1788133847218,"version":"build-2803163510"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T00:00:00Z","timestamp":1635033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T00:00:00Z","timestamp":1635033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p><jats:italic>Raoultella ornithinolytica<\/jats:italic> is a Gram-negative bacillus that resembles Klebsiella. This bacterium is present in many soil and aquatic environments and is a major causative agent of healthcare-associated infections (HAIs) in medical staff. Clinically, it has been reported to contribute to nosocomial infections in patients that include but are not limited to gastrointestinal, skin, and genitourinary tract infections. These complications are most common in hospitalized patients with underlying immunodeficiency, multiple comorbidities, or those receiving invasive surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We present a case of a 25-year-old patient with a <jats:italic>R. ornithinolytica<\/jats:italic> infection. The patient had no history of any disease. Her main complaints were high fever, a scattered maculopapular rash, and superficial lymph node enlargement (SLNE). Peripheral blood samples were collected for high-throughput sequencing analysis to identify pathogenic microorganisms. The results confirmed a <jats:italic>R. ornithinolytica<\/jats:italic> infection, which was treated successfully using meropenem. Loratadine was also administered to treat the patient\u2019s compromised skin condition caused by an allergic reaction.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>To our knowledge, this is the first case of a systemic maculopapular rash and superficial lymphadenopathy caused by a <jats:italic>R. ornithinolytica<\/jats:italic> infection acquired at the community level. Based on this case, we recommend a combination of antibiotic and antiallergic drugs to treat a <jats:italic>R. ornithinolytica<\/jats:italic> infection and associated allergic reaction to the bacteria.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-021-06799-w","type":"journal-article","created":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T16:02:40Z","timestamp":1635091360000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A case report of community-acquired Raoultella ornithinolytica infection in a healthy, young individual"],"prefix":"10.1186","volume":"21","author":[{"given":"Xiaonan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3854-9803","authenticated-orcid":false,"given":"Zhijie","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,24]]},"reference":[{"issue":"6","key":"6799_CR1","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s12223-015-0390-2","volume":"60","author":"A S\u0119kowska","year":"2015","unstructured":"S\u0119kowska A, Dylewska K, Gospodarek E, Bogiel T. Catheter-related blood stream infection caused by Raoultella ornithinolytica. Folia Microbiol (Praha). 2015;60(6):493\u20135. https:\/\/doi.org\/10.1007\/s12223-015-0390-2.","journal-title":"Folia Microbiol (Praha)"},{"issue":"6","key":"6799_CR2","doi-asserted-by":"publisher","first-page":"375","DOI":"10.11648\/j.ajhr.20140206.19","volume":"2","author":"EA Ozkan","year":"2014","unstructured":"Ozkan EA, Khosroshahi HE, Yilmaz N, Gecit UA, Domur E. A rare case of a newborn with urinary tract infection by Raoultella ornithinolytica. Am J Health Res. 2014;2(6):375\u20137. https:\/\/doi.org\/10.11648\/j.ajhr.20140206.19.","journal-title":"Am J Health Res"},{"key":"6799_CR3","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ijid.2016.02.014","volume":"45","author":"P Seng","year":"2016","unstructured":"Seng P, Boushab BM, Romain F, Gouriet F, Bruder N, Martin C, Paganelli F, Bernit E, Le Treut YP, Thomas P, Papazian L, Raoult D, Stein A. Emerging role of Raoultella ornithinolytica in human infections: a series of cases and review of the literature. Int J Infect Dis. 2016;45:65\u201371. https:\/\/doi.org\/10.1016\/j.ijid.2016.02.014.","journal-title":"Int J Infect Dis"},{"key":"6799_CR4","unstructured":"Hostack\u00e1 A, Klokocn\u00edkov\u00e1. Antibiotic susceptibility, serum response and surface properties of Klebsiella species. Microbios. 2001;104(408):115\u201324."},{"issue":"6","key":"6799_CR5","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.jiac.2018.12.011","volume":"25","author":"A B\u00fcy\u00fckcam","year":"2019","unstructured":"B\u00fcy\u00fckcam A, Liste \u00dc, B\u0131\u00e7ak\u00e7\u0131gil A, Kara A, Sancak B. A case of Raoultella ornithinolytica urinary tract infection in a pediatric patient. J Infect Chemother. 2019;25(6):467\u20139. https:\/\/doi.org\/10.1016\/j.jiac.2018.12.011.","journal-title":"J Infect Chemother"},{"key":"6799_CR6","doi-asserted-by":"publisher","unstructured":"S\u00e1nchez-C\u00f3dez M, Lubi\u00e1n-Guti\u00e9rrez M, Blanca-Garc\u00eda JA, P\u00e9rez Arag\u00f3n C. Infecci\u00f3n asociada a cat\u00e9ter porLeclercia adecarboxylata y Raoultella ornithinolytica en un paciente con enfermedad mitocondrial [Leclercia adecarboxylata and Raoultella ornithinolytica catheter-related infection in a child with mitocondrial disease]. Arch Argent Pediatr. 2019;117(2):e147\u20139. (Spanish). https:\/\/doi.org\/10.5546\/aap.2019.e147.","DOI":"10.5546\/aap.2019.e147"},{"issue":"1","key":"6799_CR7","doi-asserted-by":"publisher","first-page":"9462","DOI":"10.1038\/s41598-018-27833-z","volume":"8","author":"M Beye","year":"2018","unstructured":"Beye M, Hasni I, Seng P, Michelle C, La Scola B, Raoult D, Fournier PE. Genomic analysis of a Raoultella ornithinolytica strain causing prosthetic joint infection in an immunocompetent patient. Sci Rep. 2018;8(1):9462. https:\/\/doi.org\/10.1038\/s41598-018-27833-z.","journal-title":"Sci Rep"},{"key":"6799_CR8","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.rmcr.2018.05.006","volume":"24","author":"JR Van Cleve","year":"2018","unstructured":"Van Cleve JR, Boucher BA, Smith DV, et al. Ventilator associated pneumonia caused by Raoultella ornithinolytica in two immunocompetent trauma patients. Respir Med Case Rep. 2018;24:135\u20137. https:\/\/doi.org\/10.1016\/j.rmcr.2018.05.006.","journal-title":"Respir Med Case Rep"},{"key":"6799_CR9","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ijid.2016.02.014","volume":"45","author":"P Seng","year":"2016","unstructured":"Seng P, Boushab BM, Romain F, et al. Emerging role of Raoultella ornithinolytica in human infections: a series of cases and review of the literature. Int J Infect Dis. 2016;45:65\u201371. https:\/\/doi.org\/10.1016\/j.ijid.2016.02.014.","journal-title":"Int J Infect Dis"},{"key":"6799_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2020.e00736","volume":"20","author":"A Surani","year":"2020","unstructured":"Surani A, Slama EM, Thomas S, Ross RW, Cunningham SC. Raoultella ornithinolytica and Klebsiella oxytoca pyogenic liver abscess presenting as chronic cough. IDCases. 2020;20: e00736. https:\/\/doi.org\/10.1016\/j.idcr.2020.e00736.","journal-title":"IDCases"},{"key":"6799_CR11","doi-asserted-by":"publisher","unstructured":"Hajjar R, Schwenter F, Su SH, Gasse MC, Sebajang H. Community-acquired infection to Raoultella ornithinolytica presenting as appendicitis and shock in a healthy individual. J Surg Case Rep. 2018;2018(5):rjy097. https:\/\/doi.org\/10.1093\/jscr\/rjy097.","DOI":"10.1093\/jscr\/rjy097"},{"issue":"7","key":"6799_CR12","doi-asserted-by":"publisher","first-page":"914","DOI":"10.4103\/njcp.njcp_337_16","volume":"20","author":"M Singh","year":"2017","unstructured":"Singh M, Kaur I, Mundi DK, Kaur A. ENT infection caused by Raoultella ornithinolytica. Niger J Clin Pract. 2017;20(7):914\u20137. https:\/\/doi.org\/10.4103\/njcp.njcp_337_16.","journal-title":"Niger J Clin Pract"},{"key":"6799_CR13","doi-asserted-by":"publisher","unstructured":"Stock I, Wiedemann B. Natural antibiotic susceptibility of Klebsiella pneumoniae, K. oxytoca, K. planticola, K. ornithinolytica and K. terrigena strains. J Med Microbiol. 2001;50(5):396\u2013406. https:\/\/doi.org\/10.1099\/0022-1317-50-5-396.","DOI":"10.1099\/0022-1317-50-5-396"},{"key":"6799_CR14","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.2147\/IDR.S191387","volume":"13","author":"R Hajjar","year":"2020","unstructured":"Hajjar R, Ambaraghassi G, Sebajang H, Schwenter F, Su SH. Raoultella ornithinolytica: emergence and resistance. Infect Drug Resist. 2020;13:1091\u2013104. https:\/\/doi.org\/10.2147\/IDR.S191387.","journal-title":"Infect Drug Resist"},{"issue":"7","key":"6799_CR15","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1089\/mdr.2019.0016","volume":"25","author":"A Piccirilli","year":"2019","unstructured":"Piccirilli A, Pompilio A, Rossi L, Segatore B, Amicosante G, Rosatelli G, Perilli M, Di Bonaventura G. Identification of CTX-M-15 and CTX-M-27 in antibiotic-resistant Gram-negative bacteria isolated from three rivers running in Central Italy. Microb Drug Resist. 2019;25(7):1041\u20139. https:\/\/doi.org\/10.1089\/mdr.2019.0016.","journal-title":"Microb Drug Resist"},{"issue":"9","key":"6799_CR16","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.1128\/AEM.00054-13","volume":"79","author":"K Zurfluh","year":"2013","unstructured":"Zurfluh K, H\u00e4chler H, N\u00fcesch-Inderbinen M, Stephan R. Characteristics of extended-spectrum \u03b2-lactamase- and carbapenemase-producing Enterobacteriaceae isolates from rivers and lakes in Switzerland. Appl Environ Microbiol. 2013;79(9):3021\u20136. https:\/\/doi.org\/10.1128\/AEM.00054-13.","journal-title":"Appl Environ Microbiol"},{"issue":"1","key":"6799_CR17","doi-asserted-by":"publisher","first-page":"e01335","DOI":"10.1128\/AAC.01335-19","volume":"64","author":"A Iovleva","year":"2019","unstructured":"Iovleva A, Mettus RT, McElheny CL, Griffith MP, Mustapha MM, Pasculle AW, Shields RK, Cooper VS, Doi Y. High-level carbapenem resistance in OXA-232-producing Raoultella ornithinolytica triggered by ertapenem therapy. Antimicrob Agents Chemother. 2019;64(1):e01335-19. https:\/\/doi.org\/10.1128\/AAC.01335-19.","journal-title":"Antimicrob Agents Chemother"},{"key":"6799_CR18","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.3389\/fmicb.2017.01143","volume":"8","author":"Y Yao","year":"2017","unstructured":"Yao Y, Lazaro-Perona F, Falgenhauer L, Valverde A, Imirzalioglu C, Dominguez L, Cant\u00f3n R, Mingorance J, Chakraborty T. Insights into a novel blaKPC-2-encoding IncP-6 plasmid reveal carbapenem-resistance circulation in several Enterobacteriaceae species from wastewater and a hospital source in Spain. Front Microbiol. 2017;8:1143. https:\/\/doi.org\/10.3389\/fmicb.2017.01143.","journal-title":"Front Microbiol"},{"issue":"24","key":"6799_CR19","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.2146\/ajhp150221","volume":"72","author":"WK Kabbara","year":"2015","unstructured":"Kabbara WK, Zgheib YR. Diabetic foot infection caused by Raoultella ornithinolytica. Am J Health Syst Pharm. 2015;72(24):2147\u20139. https:\/\/doi.org\/10.2146\/ajhp150221.","journal-title":"Am J Health Syst Pharm"},{"issue":"4","key":"6799_CR20","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1097\/INF.0000000000001050","volume":"35","author":"K Yamakawa","year":"2016","unstructured":"Yamakawa K, Yamagishi Y, Miyata K, Shimomura Y, Iwata A, Hori T, Mikamo H, Okumura A. Bacteremia caused by Raoultella ornithinolytica in two children. Pediatr Infect Dis J. 2016;35(4):452\u20133. https:\/\/doi.org\/10.1097\/INF.0000000000001050.","journal-title":"Pediatr Infect Dis J"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-021-06799-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12879-021-06799-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-021-06799-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T16:04:32Z","timestamp":1635091472000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-021-06799-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,24]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["6799"],"URL":"https:\/\/doi.org\/10.1186\/s12879-021-06799-w","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,24]]},"assertion":[{"value":"20 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The experimental protocol was established, according to the ethical guidelines of the Helsinki Declaration and was approved by the Human Ethics Committee of Huashan Hospital North Fudan University. Written informed consent was obtained from individual.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this Case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1095"}}