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This study evaluated the <jats:italic>TNFA<\/jats:italic> -308G&gt;A and <jats:italic>IL10<\/jats:italic> -1082A&gt;G polymorphisms in the susceptibility and progress of chronic hepatitis C.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Method<\/jats:title>\n                <jats:p>The study included 101 samples from patients with chronic hepatitis C and 300 samples from healthy donors. Polymorphisms were typed by real-time PCR and were analyzed for associations with histopathological parameters (according to METAVIR classification) and HCV viral load.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The polymorphic genotype for the <jats:italic>TNFA<\/jats:italic> -308G&gt;A variant was not present in the group of patients with chronic hepatitis C and its absence could be associated with protection against HCV infection (p\u2009=\u20090.0477). Patients with the polymorphic genotype of the <jats:italic>IL10<\/jats:italic> -1082A&gt;G polymorphism had higher HCV viral load than wild-type patients (p\u2009=\u20090.0428). Neither polymorphism was associated with different levels of necroinflammatory activity or fibrosis scores.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our results suggest the polymorphic genotype at <jats:italic>TNFA<\/jats:italic> -308G&gt;A as protective against chronic HCV infection, and the polymorphic genotype at the <jats:italic>IL10<\/jats:italic> -1082A&gt;G variant associated with higher HCV viral load. Further studies must be performed in order to confirm these associations.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-021-06835-9","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T16:03:23Z","timestamp":1635955403000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["TNFA -308G&gt;A and IL10 -1082A&gt;G polymorphisms seem to be predictive biomarkers of chronic HCV infection"],"prefix":"10.1186","volume":"21","author":[{"given":"Ang\u00e9lica Menezes","family":"Santiago","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ednelza","family":"da Silva Gra\u00e7a Amoras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Alice Freitas","family":"Queiroz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone Regina Souza","family":"da Silva Conde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izaura Maria Vieira","family":"Cayres-Vallinoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Ishak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Carlos Ros\u00e1rio","family":"Vallinoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,3]]},"reference":[{"key":"6835_CR1","unstructured":"World Health Organization. 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All participants were informed about the objectives of the study, and those who agreed to participate signed an informed consent form and answered an epidemiological questionnaire.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1133"}}