{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T13:08:40Z","timestamp":1724936920493},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"crossref","award":["2020J011068","2019J01175"],"award-info":[{"award-number":["2020J011068","2019J01175"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Startup Fund for scientific research, Fujian Medical University","award":["2018QH1160"],"award-info":[{"award-number":["2018QH1160"]}]},{"name":"Young and Middle-aged Talents Training Project of Fujian Provincial Health Commission","award":["2018-ZQN-1"],"award-info":[{"award-number":["2018-ZQN-1"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Identifying the biological subclasses of septic shock might provide specific targeted therapies for the treatment and prognosis of septic shock. It might be possible to find biological markers for the early prediction of septic shock prognosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The data were obtained from the Gene Expression Omnibus databases (GEO) in NCBI. GO enrichment and KEGG pathway analyses were performed to investigate the functional annotation of up- and downregulated DEGs. ROC curves were drawn, and their areas under the curves (AUCs) were determined to evaluate the predictive value of the key genes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>117 DEGs were obtained, including 36 up- and 81 downregulated DEGs. The AUC for the <jats:italic>MME<\/jats:italic> gene was 0.879, as a key gene with the most obvious upregulation in septic shock. The AUC for the <jats:italic>THBS1<\/jats:italic> gene was 0.889, as a key downregulated gene with the most obvious downregulation in septic shock.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The upregulation of <jats:italic>MME<\/jats:italic> via the renin-angiotensin system pathway and the downregulation of <jats:italic>THBS1<\/jats:italic> through the PI3K\u2013Akt signaling pathway might have implications for the early prediction of prognosis of septic shock in patients with pneumopathies.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-021-06888-w","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T12:02:49Z","timestamp":1637928169000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Identification of transcriptomics biomarkers for the early prediction of the prognosis of septic shock from pneumopathies"],"prefix":"10.1186","volume":"21","author":[{"given":"Songchang","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hangwei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shujuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songjing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"issue":"8","key":"6888_CR1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016;315(8):801\u201310.","journal-title":"JAMA"},{"issue":"3","key":"6888_CR2","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1007\/s00134-017-4683-6","volume":"43","author":"A Rhodes","year":"2017","unstructured":"Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, Kumar A, Sevransky JE, Sprung CL, Nunnally ME, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med. 2017;43(3):304\u201377.","journal-title":"Intensive Care Med"},{"issue":"16","key":"6888_CR3","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1056\/NEJMoa022139","volume":"348","author":"GS Martin","year":"2003","unstructured":"Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003;348(16):1546\u201354.","journal-title":"N Engl J Med"},{"issue":"11","key":"6888_CR4","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1007\/s00134-018-5377-4","volume":"44","author":"C Fleischmann-Struzek","year":"2018","unstructured":"Fleischmann-Struzek C, Mikolajetz A, Schwarzkopf D, Cohen J, Hartog CS, Pletz M, Gastmeier P, Reinhart K. Challenges in assessing the burden of sepsis and understanding the inequalities of sepsis outcomes between National Health Systems: secular trends in sepsis and infection incidence and mortality in Germany. Intensive Care Med. 2018;44(11):1826\u201335.","journal-title":"Intensive Care Med"},{"key":"6888_CR5","doi-asserted-by":"publisher","first-page":"175346661987984","DOI":"10.1177\/1753466619879840","volume":"13","author":"J Zhang","year":"2019","unstructured":"Zhang J, Luo Y, Wang X, Zhu J, Li Q, Feng J, He D, Zhong Z, Zheng X, Lu J, et al. Global transcriptional regulation of STAT3- and MYC-mediated sepsis-induced ARDS. Ther Adv Respir Dis. 2019;13:1753466619879840.","journal-title":"Ther Adv Respir Dis"},{"issue":"10219","key":"6888_CR6","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","volume":"395","author":"KE Rudd","year":"2020","unstructured":"Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, Colombara DV, Ikuta KS, Kissoon N, Finfer S, et al. Global, regional, and national sepsis incidence and mortality, 1990\u20132017: analysis for the Global Burden of Disease Study. Lancet. 2020;395(10219):200\u201311.","journal-title":"Lancet"},{"issue":"5","key":"6888_CR7","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.jinf.2017.08.012","volume":"75","author":"CC Lee","year":"2017","unstructured":"Lee CC, Yo CH, Lee MG, Tsai KC, Lee SH, Chen YS, Lee WC, Hsu TC, Lee SH, Chang SS. Adult sepsis\u2014a nationwide study of trends and outcomes in a population of 23 million people. J Infect. 2017;75(5):409\u201319.","journal-title":"J Infect"},{"issue":"1","key":"6888_CR8","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1080\/22221751.2020.1746199","volume":"9","author":"L Lin","year":"2020","unstructured":"Lin L, Lu L, Cao W, Li T. Hypothesis for potential pathogenesis of SARS-CoV-2 infection\u2014a review of immune changes in patients with viral pneumonia. Emerg Microbes Infect. 2020;9(1):727\u201332.","journal-title":"Emerg Microbes Infect"},{"key":"6888_CR9","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.2147\/IDR.S157269","volume":"11","author":"J Yang","year":"2018","unstructured":"Yang J, Zhang S, Zhang J, Dong J, Wu J, Zhang L, Guo P, Tang S, Zhao Z, Wang H, et al. Identification of key genes and pathways using bioinformatics analysis in septic shock children. Infect Drug Resist. 2018;11:1163\u201374.","journal-title":"Infect Drug Resist"},{"key":"6888_CR10","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/1741-7015-7-34","volume":"7","author":"HR Wong","year":"2009","unstructured":"Wong HR, Cvijanovich N, Lin R, Allen GL, Thomas NJ, Willson DF, Freishtat RJ, Anas N, Meyer K, Checchia PA, et al. Identification of pediatric septic shock subclasses based on genome-wide expression profiling. BMC Med. 2009;7:34.","journal-title":"BMC Med"},{"issue":"11\u201312","key":"6888_CR11","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.2119\/molmed.2011.00169","volume":"17","author":"JL Wynn","year":"2011","unstructured":"Wynn JL, Cvijanovich NZ, Allen GL, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Checchia PA, Lin R, Shanley TP, et al. The influence of developmental age on the early transcriptomic response of children with septic shock. Mol Med. 2011;17(11\u201312):1146\u201356.","journal-title":"Mol Med"},{"issue":"7","key":"6888_CR12","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, Smyth GK. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7):e47.","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"6888_CR13","doi-asserted-by":"publisher","first-page":"21260","DOI":"10.1002\/jcp.28731","volume":"234","author":"J Liu","year":"2019","unstructured":"Liu J, Nie S, Gao M, Jiang Y, Wan Y, Ma X, Zhou S, Cheng W. Identification of EPHX2 and RMI2 as two novel key genes in cervical squamous cell carcinoma by an integrated bioinformatic analysis. J Cell Physiol. 2019;234(11):21260\u201373.","journal-title":"J Cell Physiol"},{"issue":"1","key":"6888_CR14","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 2000;25(1):25\u20139.","journal-title":"Nat Genet"},{"issue":"1","key":"6888_CR15","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000;28(1):27\u201330.","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"6888_CR16","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa M. Toward understanding the origin and evolution of cellular organisms. Protein Sci. 2019;28(11):1947\u201351.","journal-title":"Protein Sci"},{"issue":"D1","key":"6888_CR17","doi-asserted-by":"publisher","first-page":"D545","DOI":"10.1093\/nar\/gkaa970","volume":"49","author":"M Kanehisa","year":"2021","unstructured":"Kanehisa M, Furumichi M, Sato Y, Ishiguro-Watanabe M, Tanabe M. KEGG: integrating viruses and cellular organisms. Nucleic Acids Res. 2021;49(D1):D545\u201351.","journal-title":"Nucleic Acids Res"},{"key":"6888_CR18","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/1471-2105-12-77","volume":"12","author":"X Robin","year":"2011","unstructured":"Robin X, Turck N, Hainard A, Tiberti N, Lisacek F, Sanchez JC, Muller M. pROC: an open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinform. 2011;12:77.","journal-title":"BMC Bioinform"},{"issue":"5","key":"6888_CR19","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/S2213-2600(14)70061-X","volume":"2","author":"JL Vincent","year":"2014","unstructured":"Vincent JL, Marshall JC, Namendys-Silva SA, Francois B, Martin-Loeches I, Lipman J, Reinhart K, Antonelli M, Pickkers P, Njimi H, et al. Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit. Lancet Respir Med. 2014;2(5):380\u20136.","journal-title":"Lancet Respir Med"},{"issue":"3","key":"6888_CR20","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1164\/rccm.201504-0781OC","volume":"193","author":"C Fleischmann","year":"2016","unstructured":"Fleischmann C, Scherag A, Adhikari NK, Hartog CS, Tsaganos T, Schlattmann P, Angus DC, Reinhart K, International Forum of Acute Care T. Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations. Am J Respir Crit Care Med. 2016;193(3):259\u201372.","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"6888_CR21","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1186\/s13054-018-2208-5","volume":"22","author":"S Eitze","year":"2018","unstructured":"Eitze S, Fleischmann-Struzek C, Betsch C, Reinhart K, vaccination60+ study g. Determinants of sepsis knowledge: a representative survey of the elderly population in Germany. Crit Care. 2018;22(1):273.","journal-title":"Crit Care"},{"issue":"6","key":"6888_CR22","first-page":"2749","volume":"12","author":"J Lu","year":"2020","unstructured":"Lu J, Li Q, Wu Z, Zhong Z, Ji P, Li H, He C, Feng J, Zhang J. Two gene set variation indexes as potential diagnostic tool for sepsis. Am J Transl Res. 2020;12(6):2749\u201359.","journal-title":"Am J Transl Res"},{"issue":"2","key":"6888_CR23","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3390\/jcdd6020014","volume":"6","author":"A Nehme","year":"2019","unstructured":"Nehme A, Zouein FA, Zayeri ZD, Zibara K. An update on the tissue renin angiotensin system and its role in physiology and pathology. J Cardiovasc Dev Dis. 2019;6(2):14.","journal-title":"J Cardiovasc Dev Dis"},{"issue":"1","key":"6888_CR24","doi-asserted-by":"publisher","first-page":"R24","DOI":"10.1186\/cc8887","volume":"14","author":"KC Doerschug","year":"2010","unstructured":"Doerschug KC, Delsing AS, Schmidt GA, Ashare A. Renin-angiotensin system activation correlates with microvascular dysfunction in a prospective cohort study of clinical sepsis. Crit Care. 2010;14(1):R24.","journal-title":"Crit Care"},{"key":"6888_CR25","doi-asserted-by":"publisher","DOI":"10.4172\/2155-6156.1000615","author":"RS Padda","year":"2015","unstructured":"Padda RS, Shi Y, Lo CS, Zhang SL, Chan JS. Angiotensin-(1\u20137): a novel peptide to treat hypertension and nephropathy in diabetes? J Diabetes Metab. 2015. https:\/\/doi.org\/10.4172\/2155-6156.1000615.","journal-title":"J Diabetes Metab"},{"issue":"1","key":"6888_CR26","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1038\/s41598-020-79902-x","volume":"11","author":"HJ Tsai","year":"2021","unstructured":"Tsai HJ, Shih CC, Chang KY, Liao MH, Liaw WJ, Wu CC, Tsao CM. Angiotensin-(1\u20137) treatment blocks lipopolysaccharide-induced organ damage, platelet dysfunction, and IL-6 and nitric oxide production in rats. Sci Rep. 2021;11(1):610.","journal-title":"Sci Rep"},{"issue":"3","key":"6888_CR27","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","volume":"98","author":"SJ Forrester","year":"2018","unstructured":"Forrester SJ, Booz GW, Sigmund CD, Coffman TM, Kawai T, Rizzo V, Scalia R, Eguchi S. Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology. Physiol Rev. 2018;98(3):1627\u2013738.","journal-title":"Physiol Rev"},{"key":"6888_CR28","doi-asserted-by":"publisher","first-page":"173953","DOI":"10.1016\/j.ejphar.2021.173953","volume":"897","author":"D Fernandes","year":"2021","unstructured":"Fernandes D, Pacheco LK, Sordi R, Scheschowitsch K, Ramos GC, Assreuy J. Angiotensin II receptor type 1 blockade improves hyporesponsiveness to vasopressors in septic shock. Eur J Pharmacol. 2021;897:173953.","journal-title":"Eur J Pharmacol"},{"issue":"7","key":"6888_CR29","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1007\/s10495-016-1256-z","volume":"21","author":"L Zhang","year":"2016","unstructured":"Zhang L, Ren Z, Yang Q, Ding G. Csk regulates angiotensin II-induced podocyte apoptosis. Apoptosis. 2016;21(7):846\u201355.","journal-title":"Apoptosis"},{"key":"6888_CR30","doi-asserted-by":"publisher","first-page":"172516","DOI":"10.1016\/j.ejphar.2019.172516","volume":"859","author":"Y Yang","year":"2019","unstructured":"Yang Y, Tian T, Wang Y, Li Z, Xing K, Tian G. SIRT6 protects vascular endothelial cells from angiotensin II-induced apoptosis and oxidative stress by promoting the activation of Nrf2\/ARE signaling. Eur J Pharmacol. 2019;859:172516.","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"6888_CR31","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1186\/s13287-020-02015-9","volume":"11","author":"Y Mizuta","year":"2020","unstructured":"Mizuta Y, Akahoshi T, Guo J, Zhang S, Narahara S, Kawano T, Murata M, Tokuda K, Eto M, Hashizume M, et al. Exosomes from adipose tissue-derived mesenchymal stem cells ameliorate histone-induced acute lung injury by activating the PI3K\/Akt pathway in endothelial cells. Stem Cell Res Ther. 2020;11(1):508.","journal-title":"Stem Cell Res Ther"},{"issue":"12","key":"6888_CR32","doi-asserted-by":"publisher","first-page":"3178","DOI":"10.1111\/jcmm.12871","volume":"21","author":"L Chen","year":"2017","unstructured":"Chen L, Liu P, Feng X, Ma C. Salidroside suppressing LPS-induced myocardial injury by inhibiting ROS-mediated PI3K\/Akt\/mTOR pathway in vitro and in vivo. J Cell Mol Med. 2017;21(12):3178\u201389.","journal-title":"J Cell Mol Med"},{"issue":"5","key":"6888_CR33","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1097\/SHK.0000000000001746","volume":"56","author":"DMD Santos","year":"2021","unstructured":"Santos DMD, Da Silva EAP, Oliveira JYS, Marinho YYM, Santana IR, Heimfarth L, Pereira EWM, Junior LJQ, Assreuy J, Menezes IAC, et al. The therapeutic value of hydralazine in reducing inflammatory response, oxidative stress, and mortality in animal sepsis: involvement of the PI3K\/AKT pathway. Shock. 2021;56(5):782\u201392.","journal-title":"Shock"},{"issue":"3","key":"6888_CR34","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/s41419-021-03532-y","volume":"12","author":"X Chen","year":"2021","unstructured":"Chen X, Guo ZQ, Cao D, Chen Y, Chen J. MYC-mediated upregulation of PNO1 promotes glioma tumorigenesis by activating THBS1\/FAK\/Akt signaling. Cell Death Dis. 2021;12(3):244.","journal-title":"Cell Death Dis"},{"issue":"9","key":"6888_CR35","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1097\/CCM.0000000000001740","volume":"44","author":"S Neugebauer","year":"2016","unstructured":"Neugebauer S, Giamarellos-Bourboulis EJ, Pelekanou A, Marioli A, Baziaka F, Tsangaris I, Bauer M, Kiehntopf M. Metabolite profiles in sepsis: developing prognostic tools based on the type of infection. Crit Care Med. 2016;44(9):1649\u201362.","journal-title":"Crit Care Med"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-021-06888-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12879-021-06888-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-021-06888-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T12:03:17Z","timestamp":1637928197000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-021-06888-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,26]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["6888"],"URL":"https:\/\/doi.org\/10.1186\/s12879-021-06888-w","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,26]]},"assertion":[{"value":"1 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study has been approved by the Fujian Provincial Hospital Ethics Committee. The study followed the principles of the Declaration of Helsinki. All data were obtained from a public domain database.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1190"}}