{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:44:44Z","timestamp":1789562684944,"version":"build-2803163510"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p><jats:italic>Trichosporon asahii<\/jats:italic> is an opportunistic fungus that causes infections in immunosuppressed patients. It is rarely seen in children and immunocompetent hosts. The mortality rates are still high despite early treatment with proper antifungal drugs. <jats:italic>Trichosporon asahii<\/jats:italic> mastoiditis in an immunocompetent child makes this case challenging.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>This report presents a case of <jats:italic>Trichosporon asahii<\/jats:italic> mastoiditis which was complicated by transverse sinus thrombosis, in an otherwise healthy 21-month-old girl, and successfully treated with voriconazole. <jats:italic>Trichosporon asahii<\/jats:italic> was isolated, in three different occasions, from ear discharge of an immunocompetent healthy child, who presented with prolonged history of fever and received appropriate dosages of multiple types of antimicrobials as an outpatient but without improvement. After 48\u00a0h of starting the Voriconzole; post auricular swelling and ear discharge improved significantly.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>A high index of clinical and microbiological suspicion is needed for optimal diagnosis of <jats:italic>Trichosporon<\/jats:italic> infection. <jats:italic>Trichosporon asahii<\/jats:italic> can also cause infection in immunocompetent individual even without previous history of hospitalization or intervention. We emphasize the importance of early pediatric infectious evaluation and intervention<jats:bold>.<\/jats:bold><\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-021-06915-w","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T11:02:33Z","timestamp":1638874953000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Complicated Trichosporon asahii mastoiditis in immunocompetent child"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7922-6878","authenticated-orcid":false,"given":"Miral","family":"Al Momani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawood H.","family":"Yusef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du\u2019a","family":"Hamasha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moh\u2019d Rawhi Abu","family":"Hamad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Farran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"issue":"1","key":"6915_CR1","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.jmii.2013.01.003","volume":"49","author":"A Ozkaya-Parlakay","year":"2016","unstructured":"Ozkaya-Parlakay A, Karadag-Oncel E, Cengiz AB, et al. Trichosporon asahii sepsis in a patient with pediatric malignancy. J Microbiol Immunol Infect. 2016;49(1):146\u20139.","journal-title":"J Microbiol Immunol Infect"},{"issue":"12","key":"6915_CR2","doi-asserted-by":"publisher","first-page":"4420","DOI":"10.1128\/JCM.39.12.4420-4425.2001","volume":"39","author":"DG Wolf","year":"2001","unstructured":"Wolf DG, Falk R, Hacham M, et al. Multidrug-resistant Trichosporon asahii infection of nongranulocytopenic patients in three intensive care units. J Clin Microbiol. 2001;39(12):4420\u20135.","journal-title":"J Clin Microbiol"},{"issue":"9","key":"6915_CR3","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/s13312-012-0137-y","volume":"49","author":"VM Vashishtha","year":"2012","unstructured":"Vashishtha VM, Mittal A, Garg A. A fatal outbreak of Trichosporon asahii sepsis in a neonatal intensive care Unit. 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Trichosporon asahii urinary tract infection in immunocompetent patients. Med J Armed Forces India. 2015;71(4):373\u20136.","journal-title":"Med J Armed Forces India"},{"issue":"Suppl 1","key":"6915_CR7","first-page":"54","volume":"91","author":"P Cassano","year":"2020","unstructured":"Cassano P, Ciprandi G, Passali D. Acute mastoiditis in children. Acta Biomed. 2020;91(Suppl 1):54\u20139.","journal-title":"Acta Biomed"},{"key":"6915_CR8","first-page":"651315","volume":"2015","author":"HG Tanyildiz","year":"2015","unstructured":"Tanyildiz HG, Yesil S, Toprak S, et al. Two\u00a0case\u00a0presentations\u00a0infected\u00a0by\u00a0Trichosporon\u00a0asahii\u00a0and\u00a0treated\u00a0with\u00a0voriconazole\u00a0successfully. Case Rep Infect Dis. 2015;2015:651315.","journal-title":"Case Rep Infect Dis"},{"key":"6915_CR9","doi-asserted-by":"publisher","first-page":"e169","DOI":"10.1017\/S0950268820001624","volume":"148","author":"H Li","year":"2020","unstructured":"Li H, Guo M, Wang C, et al. Epidemiological study of Trichosporon asahii infections over the past 23 years. Epidemiol Infect. 2020;148:e169.","journal-title":"Epidemiol Infect"},{"key":"6915_CR10","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.3389\/fmicb.2016.01629","volume":"7","author":"JN de Almeida J\u00fanior","year":"2016","unstructured":"de Almeida J\u00fanior JN, Hennequin C. Invasive trichosporon infection: a systematic review on a re-emerging fungal pathogen. Front Microbiol. 2016;7:1629.","journal-title":"Front Microbiol"},{"issue":"3","key":"6915_CR11","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/1469-0691.12360","volume":"20","author":"MC Arendrup","year":"2014","unstructured":"Arendrup MC, Boekhout T, Akova M, et al. ESCMID and ECMM joint clinical guidelines for the diagnosis and management of rare invasive yeast infections. 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A copy of the written consent is available for review by the Editor of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1229"}}