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The purpose of our research was to evaluate Fc\u03b3RIIb expression in serum and liver biopsy specimens from hepatitis B virus (HBV)-infected patients and to explore the association of Fc\u03b3RIIb with chronic HBV infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Enzyme-linked immunosorbent assay (ELISA) was adopted to measure the serum Fc\u03b3RIIb levels in 119 HBV-infected patients and 24 healthy controls. An immunohistochemical method was then employed to identify Fc\u03b3RIIb expression in biopsy specimens from patients with chronic hepatitis B (CHB). The integrated optical density (IOD) value was measured to represent Fc\u03b3RIIb expression levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum Fc\u03b3RIIb levels were decreased in CHB patients compared to controls (P\u2009&lt;\u20090.001). The Fc\u03b3RIIb levels in the CHB patient group were remarkably lower than those in the HBV carrier group (P\u2009&lt;\u20090.001). In addition, Fc\u03b3RIIb levels were negatively associated with AST and ALT (r\u2009=\u2009\u22120.3936, P\u2009=\u20090.0063; r\u2009=\u2009\u22120.3459, P\u2009=\u20090.0097, respectively). The IOD values of Fc\u03b3RIIb expression in the moderate and severe CHB groups were significantly lower than those in the control group (P\u2009=\u20090.006 and P\u2009&lt;\u20090.001, respectively). The Fc\u03b3RIIb level tended to be lower with pathological changes related to hepatitis. Furthermore, correlation analysis revealed that Fc\u03b3RIIb had negative correlations with AST and ALT (r\u2009=\u2009\u22120.688, P\u2009=\u20090.0016; r\u2009=\u2009\u22120.686, P\u2009=\u20090.0017, respectively) but a positive association with the platelet count (r\u2009=\u20090.6464, P\u2009=\u20090.0038).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fc\u03b3RIIb levels are significantly related to chronic HBV infection and the progression of CHB. Changes in Fc\u03b3RIIb may affect the progression of liver inflammation and fibrosis in CHB patients.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12879-021-06918-7","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T10:06:35Z","timestamp":1638957995000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The association between Fc gamma RIIb expression levels and chronic hepatitis B virus infection progression"],"prefix":"10.1186","volume":"21","author":[{"given":"Jinglan","family":"Jin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junqi","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,12,8]]},"reference":[{"key":"6918_CR1","unstructured":"Global Hepatitis Report 2017. 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