{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:53:35Z","timestamp":1791928415206,"version":"4.3.4"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Enterovirus has been described as a cause of aseptic meningitis in humorally immunosuppressed patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 67-year-old female with a history of mantle cell lymphoma on rituximab therapy presented with subacute hepatitis, myalgias, and sensorineural hearing loss several months after an initial febrile illness. She was diagnosed with enterovirus infection by CSF PCR as a unifying etiology of her presentation, representing an unusual presentation of disease.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion and conclusions<\/jats:title>\n                <jats:p>This patient\u2019s unique presentation and clinical course presents important implications in the care of similarly immunosuppressed patients with cryptic complaints.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-021-06956-1","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T10:08:03Z","timestamp":1641290883000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Chronic aseptic meningitis caused by enterovirus in a humorally immunosuppressed adult patient presenting with sensorineural hearing loss: a case report"],"prefix":"10.1186","volume":"22","author":[{"given":"Sean M.","family":"Anderson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Pisano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,4]]},"reference":[{"issue":"2","key":"6956_CR1","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1093\/clinids\/9.2.334","volume":"9","author":"RE McKinney Jr","year":"1987","unstructured":"McKinney RE Jr, Katz SL, Wilfert CM. Chronic enteroviral meningoencephalitis in agammaglobulinemic patients. Rev Infect Dis. 1987;9(2):334\u201356. https:\/\/doi.org\/10.1093\/clinids\/9.2.334 (PMID: 3296100).","journal-title":"Rev Infect Dis"},{"issue":"3","key":"6956_CR2","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1086\/345746","volume":"36","author":"P Quartier","year":"2003","unstructured":"Quartier P, Tournilhac O, Archimbaud C. Enteroviral meningoencephalitis after anti CD20 (Rituximab) treatment. Clin Infect Dis. 2003;36(3):e47\u20139.","journal-title":"Clin Infect Dis"},{"issue":"4","key":"6956_CR3","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1002\/hon.2365","volume":"35","author":"S Grisariu","year":"2016","unstructured":"Grisariu S, Vaxman I, Gatt M. Enteroviral infection in patients treated with rituximab for non-Hodgkin lymphoma: a case series and review of the literature. 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IDCases. 2019;9(17): e00558. https:\/\/doi.org\/10.1016\/j.idcr.2019.e00558 (PMID:31193253; PMCID:PMC6522838).","journal-title":"IDCases"},{"issue":"11","key":"6956_CR6","first-page":"1421","volume":"168","author":"A Schattner","year":"2003","unstructured":"Schattner A, et al. Enteroviruses and sudden deafness. CMAJ. 2003;168(11):1421\u20133.","journal-title":"CMAJ"},{"issue":"4","key":"6956_CR7","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1002\/jmv.20014","volume":"72","author":"R Mentel","year":"2004","unstructured":"Mentel R, Kaftan H, Wegner U, Reissmann A, G\u00fcrtler L. Are enterovirus infections a co-factor in sudden hearing loss? J Med Virol. 2004;72(4):625\u20139.","journal-title":"J Med Virol"},{"issue":"21","key":"6956_CR8","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1056\/NEJM198105213042107","volume":"304","author":"PJ Mease","year":"1981","unstructured":"Mease PJ, Ochs HD, Wedgwood RJ. Successful treatment of echovirus meningoencephalitis and myositis-fasciitis with intravenous immune globulin therapy in a patient with X-linked agammaglobulinemia. N Engl J Med. 1981;304(21):1278.","journal-title":"N Engl J Med"},{"issue":"19","key":"6956_CR9","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1212\/WNL.0000000000007468","volume":"92","author":"L Sham","year":"2019","unstructured":"Sham L, Bitnun A, Branson H, Hazrati LN, Dell SD, Yeung RSM, Johnstone J, Yeh EA. Treatment of rituximab-associated chronic CNS enterovirus using IVIg and fluoxetine. Neurology. 2019;92(19):916\u20138. https:\/\/doi.org\/10.1212\/WNL.0000000000007468 (PMID: 30944242).","journal-title":"Neurology"},{"issue":"4","key":"6956_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175266","volume":"12","author":"H-C Chen","year":"2017","unstructured":"Chen H-C, Chung C-H, Wang C-H, Lin J-C, Chang W-K, Lin F-H, et al. Increased risk of sudden sensorineural hearing loss in patients with hepatitis virus infection. PLoS ONE. 2017;12(4): e0175266. https:\/\/doi.org\/10.1371\/journal.pone.0175266.","journal-title":"PLoS ONE"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-021-06956-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12879-021-06956-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-021-06956-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T10:10:14Z","timestamp":1641291014000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-021-06956-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,4]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["6956"],"URL":"https:\/\/doi.org\/10.1186\/s12879-021-06956-1","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,4]]},"assertion":[{"value":"5 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written consent to publish obtained from patient. The patient also gave written consent for their personal or clinical details along with any identifying images to be published in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors as named above declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"16"}}