{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T13:27:26Z","timestamp":1792848446522,"version":"4.5.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The increasing number of dengue cases worldwide implies a greater exposure of at-risk groups, such as pregnant women. DENV infection during pregnancy has been increasingly associated with unfavorable outcomes, but the evolution of the disease and its clinical outcomes remain unclear. The objective of this study was to characterize dengue cases in reproductive aged women by comparing the development of the disease in pregnant and non-pregnant women.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A population based retrospective cohort study that used data reported in the Brazilian Mandatory Notifiable Diseases Information System from 2016 to 2019 in Paran\u00e1, Brazil. We compared sociodemographic, clinical, and laboratory variables between pregnant and non-pregnant women. Hospitalization and disease severity classification (Dengue, Dengue with warning signs, Severe Dengue) were considered outcome variables.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The two groups had differences in the year of notification, age distribution, and region of residence. Laboratory investigation was more frequent among pregnant women, and DENV-2 prevailed in both groups. The risks of hospitalization and development of Severe Dengue were higher in pregnant women. There were no deaths observed among pregnant women.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This study identified pregnancy as a risk factor for an increase in the severity of DENV infection. It reinforces the importance of identifying early signs of complication, close monitoring, and adequate treatment for pregnant women.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-021-06985-w","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T10:08:03Z","timestamp":1641290883000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Clinical outcomes of dengue virus infection in pregnant and non-pregnant women of reproductive age: a retrospective cohort study from 2016 to 2019 in Paran\u00e1, Brazil"],"prefix":"10.1186","volume":"22","author":[{"given":"Beatris Mario","family":"Martin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan Arnold","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Siqueira","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Emiko","family":"Shimakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,4]]},"reference":[{"key":"6985_CR1","unstructured":"World Health Organization. Dengue and severe dengue: key facts. World Health Organization. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dengue-and-severe-dengue. Accessed 29 Dec 2020."},{"key":"6985_CR2","unstructured":"Minist\u00e9rio da Sa\u00fade. Monitoramento dos casos de arboviroses urbanas transmitidas pelo Aedes (dengue, chikungunya e Zika), Semanas Epidemiol\u00f3gicas 01 a 52. Boletim Epidemiol\u00f3gico. 2019;51(2):1\u201316."},{"key":"6985_CR3","unstructured":"Minist\u00e9rio da Sa\u00fade. Monitoramento dos casos de dengue, febre de chikungunya e doen\u00e7a aguda pelo v\u00edrus Zika at\u00e9 a Semana Epidemiol\u00f3gica 52 de 2018. Boletim Epidemiol\u00f3gico. 2018;50(4):1\u201314."},{"key":"6985_CR4","unstructured":"Governo do Paran\u00e1 Secretaria de Estado da Sa\u00fade. Situa\u00e7\u00e3o da Dengue, Chikungunya e Zika v\u00edrus no Paran\u00e1. Informe T\u00e9cnico. 1(40):1\u201316. https:\/\/www.saude.pr.gov.br\/Editoria\/Dengue#. Accessed 14 Dec 2020."},{"key":"6985_CR5","unstructured":"Governo do Paran\u00e1 Secretaria de Estado da Sa\u00fade. Situa\u00e7\u00e3o da Dengue, Chikungunya e Zika v\u00edrus no Paran\u00e1. Informe T\u00e9cnico. 2019;1(15):1\u201318. https:\/\/www.saude.pr.gov.br\/Editoria\/Dengue#. Accessed 14 Dec 2020."},{"key":"6985_CR6","unstructured":"Governo do Paran\u00e1 Secretaria de Estado da Sa\u00fade. Situa\u00e7\u00e3o da Dengue, Chikungunya e Zika v\u00edrus no Paran\u00e1. Informe T\u00e9cnico. 2019;1(19):1\u201313. https:\/\/www.saude.pr.gov.br\/Editoria\/Dengue#. Accessed 14 Dec 2020."},{"key":"6985_CR7","unstructured":"Governo do Paran\u00e1 Secretaria de Estado da Sa\u00fade. Situa\u00e7\u00e3o da Dengue, Chikungunya e Zika v\u00edrus no Paran\u00e1. Informe T\u00e9cnico. 2020;1(44):1\u201320. https:\/\/www.saude.pr.gov.br\/Editoria\/Dengue#. Accessed 14 Dec 2020."},{"key":"6985_CR8","unstructured":"BRASIL, Minist\u00e9rio da Sa\u00fade, Secretaria de Vigil\u00e2ncia em Sa\u00fade, Departamento de Vigil\u00e2ncia das Doen\u00e7as Transmiss\u00edveis. Dengue: diagn\u00f3stico e manejo cl\u00ednico: adulto e crian\u00e7a, 5th edition. Bras\u00edlia: Minist\u00e9rio da Sa\u00fade; 2016."},{"key":"6985_CR9","unstructured":"BRASIL. Minist\u00e9rio da Sa\u00fade, Secretaria de Vigil\u00e2ncia em Sa\u00fade, Coordena\u00e7\u00e3o-Geral de Desenvolvimento da Epidemiologia em Servi\u00e7os. Guia de Vigil\u00e2ncia em Sa\u00fade. 3\u00b0 ed. Vol. \u00fanico. Bras\u00edlia: Minist\u00e9rio da Sa\u00fade; 2019. http:\/\/bvsms.saude.gov.br\/bvs\/publicacoes\/guia_vigilancia_saude_3ed.pdf."},{"key":"6985_CR10","doi-asserted-by":"publisher","first-page":"9938","DOI":"10.1038\/s41598-018-28387-w","volume":"8","author":"ES Paix\u00e3o","year":"2018","unstructured":"Paix\u00e3o ES, Harrron K, Campbell O, Teixeira MG, Costa MCN, Barreto ML, Rodrigues LC. Dengue in pregnancy and maternal mortality: a cohort analysis using routine data. Sci Rep. 2018;8:9938. https:\/\/doi.org\/10.1038\/s41598-018-28387-w.","journal-title":"Sci Rep"},{"issue":"2","key":"6985_CR11","doi-asserted-by":"publisher","first-page":"241","DOI":"10.18999\/nagjms.80.2.241","volume":"80","author":"TT Dat","year":"2018","unstructured":"Dat TT, Kotani T, Yamamoto E, Shibata K, Moriyama Y, Tsuda H, Yamashita M, et al. Dengue fever during pregnancy. Nagoya J Med Sci. 2018;80(2):241\u20137. https:\/\/doi.org\/10.18999\/nagjms.80.2.241.","journal-title":"Nagoya J Med Sci"},{"issue":"10","key":"6985_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0202005","volume":"13","author":"C Basurko","year":"2018","unstructured":"Basurko C, Everhard S, Matheus S, Restrepo M, Hild\u00e9rai H, Lambert V, Boukhari B, et al. A prospective matched study on symptomatic dengue in pregnancy. PLoS ONE. 2018;13(10):1\u201315. https:\/\/doi.org\/10.1371\/journal.pone.0202005.","journal-title":"PLoS ONE"},{"key":"6985_CR13","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.tmaid.2006.11.002","volume":"5","author":"D Carroll","year":"2007","unstructured":"Carroll D, Toovey S, Gomple AV. Dengue fever and pregnancy\u2014a review and comment. Travel Med Infect Dis. 2007;5:183\u20138.","journal-title":"Travel Med Infect Dis"},{"key":"6985_CR14","unstructured":"BRASIL. Minist\u00e9rio da Sa\u00fade, Secretaria de Vigil\u00e2ncia em sa\u00fade. Boletim epidemiol\u00f3gico \u2013 Dengue: monitoramento das primeiras semanas epidemiol\u00f3gicas (SE) de 2014, Brasil. V45 N 03; 2014."},{"key":"6985_CR15","unstructured":"BRASIL. Minist\u00e9rio da Sa\u00fade, Secretaria de Vigil\u00e2ncia em Sa\u00fade, Departamento de Vigil\u00e2ncia Epidemiol\u00f3gica. Diretrizes Nacionais para preven\u00e7\u00e3o e controle de epidemias de Dengue. S\u00e9rie A. Normas e Manuais T\u00e9cnicos ed. Bras\u00edlia: Minist\u00e9rio da Sa\u00fade; 2009."},{"key":"6985_CR16","unstructured":"BRASIL. Minist\u00e9rio da Sa\u00fade, Secretaria de Aten\u00e7\u00e3o \u00e0 Sa\u00fade, Departamento de a\u00e7\u00f5es program\u00e1ticas estrat\u00e9gicas. Manual dos comit\u00eas de mortalidade maternal, 3rd edition. Bras\u00edlia: Editora do Minist\u00e9rio da Sa\u00fade; 2009."},{"key":"6985_CR17","unstructured":"BRASIL. Minist\u00e9rio da Sa\u00fade, Secretaria de Gest\u00e3o Estrat\u00e9gica e Participativa, Departamento de articula\u00e7\u00e3o interfederativa. Tem\u00e1tico Sa\u00fade da Popula\u00e7\u00e3o Negra, vol. 7. 10 vols. Bras\u00edlia: Editora do Minist\u00e9rio da sa\u00fade; 2016."},{"key":"6985_CR18","unstructured":"Rede Interagencial de Informa\u00e7\u00f5es para Sa\u00fade: B.2 N\u00edvel de escolaridade - Ficha de qualifica\u00e7\u00e3o. http:\/\/tabnet.datasus.gov.br\/cgi\/idb2000\/fqb02.htm. Accessed 09 Jan 2020."},{"key":"6985_CR19","unstructured":"Minist\u00e9rio da Sa\u00fade; Organiza\u00e7\u00e3o Pan-Ameicana da Sa\u00fade; Funda\u00e7\u00e3o Oswaldo Cruz. A experi\u00eancia brasileira em sistemas de informa\u00e7\u00e3o em sa\u00fade. Bras\u00edlia: Editora MS; 2009."},{"issue":"3","key":"6985_CR20","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1590\/1982-0194201600049","volume":"29","author":"DYN Goto","year":"2016","unstructured":"Goto DYN, Larocca LM, Felix JVC, Kobayashi VL, Chaves MMN. Avalia\u00e7\u00e3o da oportunidade de notifica\u00e7\u00e3o da dengue no Estado do Paran\u00e1. Acta Paul Enferm. 2016;29(3):355\u201362. https:\/\/doi.org\/10.1590\/1982-0194201600049.","journal-title":"Acta Paul Enferm"},{"key":"6985_CR21","unstructured":"Goto DYN. Qualidade dos dados e oportunidade de notifica\u00e7\u00e3o da dengue no sistema de informa\u00e7\u00e3o de agravos de notifica\u00e7\u00e3o (Sinan), Paran\u00e1: uma pesquisa avaliativa. Curitiba, PR: Setor de Ci\u00eancias da Sa\u00fade, Universidade Federal do Paran\u00e1."},{"issue":"10","key":"6985_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1590\/0102-311X00187219","volume":"36","author":"LM Guimar\u00e3es","year":"2020","unstructured":"Guimar\u00e3es LM, Cunha GM. Diferen\u00e7as por sexo e idade no preenchimento da escolaridade em fichas de vigil\u00e2ncia em capitais brasileiras com maior incid\u00eancia de dengue, 2008\u20132017. Cad Saude Publica. 2020;36(10):1\u201312. https:\/\/doi.org\/10.1590\/0102-311X00187219.","journal-title":"Cad Saude Publica"},{"key":"6985_CR23","unstructured":"Desigualdades Sociais por Cor ou ra\u00e7a no Brasil. https:\/\/www.ibge.gov.br\/estatisticas\/sociais\/populacao\/25844-desigualdades-sociais-por-cor-ou-raca.html?=&t=resultados. Accessed 16 Mar 2021."},{"key":"6985_CR24","unstructured":"DATASUS Informa\u00e7\u00f5es de Sa\u00fade (TABNET). http:\/\/tabnet.datasus.gov.br\/cgi\/deftohtm.exe?ibge\/censo\/cnv\/escbpr.def. Accessed 16 Mar 2021."},{"issue":"4","key":"6985_CR25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096314","volume":"9","author":"GA Macedo","year":"2014","unstructured":"Macedo GA, Gonin MLC, Pone SM, Cruz OG, Nobre FF, et al. Sensitivity and specificity of the world health organization dengue classification schemes for severe dengue assessment in children in Rio de Janeiro. PLoS ONE. 2014;9(4): e96314. https:\/\/doi.org\/10.1371\/journal.pone.0096314.","journal-title":"PLoS ONE"},{"key":"6985_CR26","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268817002801","author":"J Wunderlich","year":"2017","unstructured":"Wunderlich J, Acu\u00f1a-Soto R, Alonso WJ. Dengue hospitalisations in Brazil: annual wave from West to East and recent increase among children. Epidemiol Infect. 2017. https:\/\/doi.org\/10.1017\/S0950268817002801.","journal-title":"Epidemiol Infect"},{"key":"6985_CR27","volume-title":"Manual de assist\u00eancia pr\u00e9-natal","author":"S Peixoto","year":"2014","unstructured":"Peixoto S. Manual de assist\u00eancia pr\u00e9-natal. 2nd ed. S\u00e3o Paulo: Federa\u00e7\u00e3o Brasileira das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia (FEBRASGO); 2014.","edition":"2"},{"issue":"11","key":"6985_CR28","doi-asserted-by":"publisher","first-page":"767","DOI":"10.3855\/jidc.908","volume":"4","author":"S Kariyawasam","year":"2010","unstructured":"Kariyawasam S, Senanayake H. Dengue infections during pregnancy: case series from a tertiary care hospital in Sri Lanka. J Infect Dev Ctries. 2010;4(11):767\u201375.","journal-title":"J Infect Dev Ctries"},{"issue":"5","key":"6985_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15446\/rsap.V21n5.76916","volume":"21","author":"CH Guiti\u00e9rrz-Aguirre","year":"2019","unstructured":"Guiti\u00e9rrz-Aguirre CH, Palomares-Leal A, Soto-Flores L, Colunga-Pedraza P, Jaime-P\u00e9rez JC, et al. Dengue during pregnancy, less incidence of thrombocytopenia than in general population. Rev Salud Publica. 2019;21(5):1\u20136. https:\/\/doi.org\/10.15446\/rsap.V21n5.76916.","journal-title":"Rev Salud Publica"},{"issue":"2","key":"6985_CR30","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3201\/eid0102.952004","volume":"1","author":"DJ Gubler","year":"1995","unstructured":"Gubler DJ, Clark GG. Dengue\/dengue hemorrhagic fever: the emergence of a global health problem. Emerg Infect Dis. 1995;1(2):55\u20137.","journal-title":"Emerg Infect Dis"},{"key":"6985_CR31","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3389\/fcimb.2017.00317","volume":"7","author":"C Guo","year":"2017","unstructured":"Guo C, Zhou Z, Wen Z, Liu Y, Zeng C, et al. Global epidemiology of dengue outbreaks in 1990\u20132015: a systematic review and meta-analysis. Front Cell Infect Microbiol. 2017;7:317.","journal-title":"Front Cell Infect Microbiol"},{"key":"6985_CR32","doi-asserted-by":"publisher","first-page":"19839","DOI":"10.3402\/iee.v3i0.19839","volume":"3","author":"AT Back","year":"2013","unstructured":"Back AT, Lundkvist A. Dengue viruses\u2014an overview. Infect Ecol Epidemiol. 2013;3:19839. https:\/\/doi.org\/10.3402\/iee.v3i0.19839.","journal-title":"Infect Ecol Epidemiol"},{"issue":"3","key":"6985_CR33","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.tim.2013.12.011","volume":"22","author":"JP Messina","year":"2014","unstructured":"Messina JP, Brady OJ, Scott TW, Zou C, Pigott DM, et al. Global spread of dengue virus types: mapping the 70 years history. Trends Microbiol. 2014;22(3):138\u201346.","journal-title":"Trends Microbiol"},{"key":"6985_CR34","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1186\/s12889-019-6641-4","volume":"19","author":"PCG Nunes","year":"2019","unstructured":"Nunes PCG, Daumas RP, S\u00e1nchez-Arcila JC, Nogueira RMR, Horta MAP, Santos FB. 30 years of fatal dengue cases in Brazil: a review. BMC Public Health. 2019;19:329.","journal-title":"BMC Public Health"},{"issue":"5","key":"6985_CR35","doi-asserted-by":"publisher","first-page":"999","DOI":"10.4269\/ajtmh.14-0628","volume":"92","author":"C-F Yung","year":"2015","unstructured":"Yung C-F, Lee K-S, Thein T-L, Tan L-K, Gan VC, Wong JG, Lye DC, Ng L-C, Leo Y-S. Specific differences in clinical manifestation, laboratory parameters and risk of severe disease in adults, Singapore. Am J Trop Med Hyg. 2015;92(5):999\u20131005. https:\/\/doi.org\/10.4269\/ajtmh.14-0628.","journal-title":"Am J Trop Med Hyg"},{"issue":"1","key":"6985_CR36","first-page":"1","volume":"58","author":"SB Halsted","year":"1980","unstructured":"Halsted SB. Dengue haemorrhagic fever\u2014a public health problem and a field for research. Bull World Health Organ. 1980;58(1):1\u201321.","journal-title":"Bull World Health Organ"},{"key":"6985_CR37","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.jinf.2004.10.003","volume":"51","author":"C Perret","year":"2005","unstructured":"Perret C, Chanthavanich P, Pengsaa K, Limkittikul K, Hutajaroen P, Bunn JE, Brabin BJ. Dengue infection during pregnancy and transplacental antibody transfer in Thai mothers. J Infect. 2005;51:287\u201393. https:\/\/doi.org\/10.1016\/j.jinf.2004.10.003.","journal-title":"J Infect"},{"key":"6985_CR38","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1038\/s41467-021-22921-7","volume":"12","author":"AF Brito","year":"2021","unstructured":"Brito AF, Machado LC, Oidtman RJ, Siconelli MJL, Tran QM, et al. Lying in wait: the resurgence of dengue v\u00edrus after the Zika epidemic in Brazil. Nat Commun. 2021;12:2619. https:\/\/doi.org\/10.1038\/s41467-021-22921-7.","journal-title":"Nat Commun"},{"key":"6985_CR39","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1111\/tmi.13200","volume":"24","author":"F Perez","year":"2019","unstructured":"Perez F, Llau A, Gutierrez G, Bezerra H, Coelho G, et al. The decline of dengue in the Americas in 2017: discussion of multiple hypotheses. Trop Med Int Health. 2019;24:442\u201353. https:\/\/doi.org\/10.1111\/tmi.13200.","journal-title":"Trop Med Int Health"},{"issue":"264","key":"6985_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13071-018-2830-8","volume":"11","author":"TS Salles","year":"2018","unstructured":"Salles TS, S\u00e1-Guimar\u00e3es T, Alvarenga ES, Guimar\u00e3es-Ribeiro V, Meneses MD, Castro-Salles PF, Santos CR, et al. History, epidemiology and diagnostics of dengue in the American and Brazilian contexts: a review. Parasites Vectors. 2018;11(264):1\u201312. https:\/\/doi.org\/10.1186\/s13071-018-2830-8.","journal-title":"Parasites Vectors"},{"issue":"1","key":"6985_CR41","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s11606-015-3438-8","volume":"31","author":"AEL Huntern","year":"2015","unstructured":"Huntern AEL, Spatz ES, Bernstein SL, Rosenthal MS. Factors influencing hospital admission of non-critically ill patients presenting to emergency department: a cross-sectional study. J Gen Intern Med. 2015;31(1):37\u201344.","journal-title":"J Gen Intern Med"},{"key":"6985_CR42","volume-title":"Dengue: guidelines for diagnosis, treatment, prevention and control","author":"World Health Organization and Special Programme for Research and Training in tropical Diseases","year":"2009","unstructured":"World Health Organization and Special Programme for Research and Training in tropical Diseases. Dengue: guidelines for diagnosis, treatment, prevention and control. France: WHO Library Catalouing-in-Publication Data; 2009."},{"key":"6985_CR43","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.ijid.2021.07.062","volume":"110","author":"R Fonseca-Portilla","year":"2021","unstructured":"Fonseca-Portilla R, Mart\u00ednez-Gil M, Morgenstern-Kaplan D. Risk factors for hospitalization and mortality due to dengue fever in a Mexican population: a retrospective cohort study. Int J Infect Dis. 2021;110:332\u20136.","journal-title":"Int J Infect Dis"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-021-06985-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12879-021-06985-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-021-06985-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T10:13:39Z","timestamp":1641291219000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-021-06985-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,4]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["6985"],"URL":"https:\/\/doi.org\/10.1186\/s12879-021-06985-w","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,4]]},"assertion":[{"value":"8 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the ethics committee of the Federal University of Paran\u00e1 (CAAE 62213916.1.0000.0102). We used a secondary database in our research and no human subject was accessed.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"As we did not access human subjects, consent for publication does not apply.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"5"}}