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In Yemen, however, its epidemiology is unknown. Therefore, this study determined its prevalence and predictors among HIV\/AIDS patients receiving antiretroviral therapy (ART) in Sana\u2019a city, the capital of\u00a0Yemen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This cross-sectional study included 402 patients receiving ART at Al-Jomhori Educational Hospital in Sana\u2019a from November 2019 to December 2020. Data about demographics, clinical characteristics and risk factors were collected using a pre-designed questionnaire. Stool samples were collected and examined for microsporidian spores using the Gram-chromotrope Kinyoun staining. Blood samples were also collected and used for CD4 cell counting by flow cytometry. Univariate analysis was used to test the association of patients\u2019 characteristics and risk factors with intestinal microsporidiosis. Multivariable logistic regression was then used to identify the independent predictors of infection. Statistical significance was considered at\n                      <jats:italic>P<\/jats:italic>\n                      -values\u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Intestinal microsporidiosis was prevalent among 14.2% (57\/402) of HIV\/AIDS patients and was significantly associated with diarrhea (OR 3.4, 95% CI 1.7\u20136.6;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001). The significant independent predictors of infection were\u2009&lt;\u2009200 CD4 cells\/\u00b5l (AOR 3.2, 95% CI 1.5\u20136.9;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.003), not washing hands after contacting soil (AOR 2.5, 95% CI 1.1\u20135.4;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.026) and before eating (AOR 3.1, 95% CI 1.5\u20136.4;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.003), eating unwashed raw produce (AOR 2.5, 95% CI 1.2\u20135.3;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.017) and absence of indoor latrines (AOR 6.2, 95% CI 1.5\u201325.9;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.012).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prevalence of intestinal microsporidiosis among HIV\/AIDS patients in Sana'a is high and comparable to that reported from\u00a0several other countries, being prevalent among approximately 14.0% of patients and significantly associated with diarrhea. It could be predicted among patients who have\u2009&lt;\u2009200 CD4 cells\/\u00b5l, have\u00a0poor hand hygiene after contacting soil and before eating, usually eat unwashed raw produce, or do not possess indoor latrines. Large-scale studies on its epidemiology and predictors among HIV\/AIDS patients across the country are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12879-021-07009-3","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T05:08:03Z","timestamp":1641272883000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Intestinal microsporidiosis among HIV\/AIDS patients receiving antiretroviral therapy in Sana\u2019a city, Yemen: first report on prevalence and predictors"],"prefix":"10.1186","volume":"22","author":[{"given":"Kwkab A. 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