{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T08:30:15Z","timestamp":1793781015520,"version":"4.6.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T00:00:00Z","timestamp":1646438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T00:00:00Z","timestamp":1646438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>TB is still one of the leading causes of death among HIV patients. This study evaluates the effect of TB on the mortality rate, survival time, and predictors of survival in patients with AIDS living in different areas in S\u00e3o Paulo State (SPS).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Retrospective cohort of adolescents and adults with AIDS, diagnosed between 2003 and 2007 and followed-up until 2014. Data were obtained from the Brazilian Ministry of Health. Mortality rates were estimated by person-years. Survival analysis used the date of diagnosis as the reference for the construction of Kaplan\u2013Meier curves. The Cox model was used for the investigation of survival-associated factors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 35,515 patients were included, of whom 63.0% were male; 64.7% at the age group of 30 to 49\u00a0years, 64.4% were white, 12.9% co-infected with TB, and 37.6% had CD4 count above 200\u00a0cells\/mm<jats:sup>3<\/jats:sup> at diagnosis of AIDS. The 12-year survival probabilities were 74.1% and 55.7% among patients without and with TB co-infection, respectively. After adjustment for sex, age and year of diagnosis, the following exposures were independently associated with lower survival: residing in municipalities of the Interior (Hazard ratio (HR)\u2009=\u20091.43) and Coastal Area (HR\u2009=\u20091.9); illiteracy (HR\u2009=\u20092.61); being co-infected with TB (HR\u2009=\u20091.70); CD4 count below 200\u00a0cells\/mm<jats:sup>3<\/jats:sup> at AIDS diagnosis (HR\u2009=\u20092.31); viral load above 500\u00a0copies\/ml at AIDS diagnosis (HR\u2009=\u20091.99); HAART1 regimen (one non-nucleoside reverse transcriptase inhibitor or boosted old protease inhibitors) (HR\u2009=\u20091.94).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The impact of TB on survival of AIDS was heterogeneous, and affected by age, years of formal education, early AIDS diagnosis, and proper ARV treatment. These factors may not fully explain the different survival outcomes in each of the four regions within the same state. These results may subsidize focused interventions and public health policies conveying specific needs in each of the areas.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-022-07232-6","type":"journal-article","created":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T05:03:27Z","timestamp":1646456607000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Mortality and survival of tuberculosis coinfected patients living with AIDS in S\u00e3o Paulo, Brazil: a 12-year cohort study"],"prefix":"10.1186","volume":"22","author":[{"given":"Mariza Vono","family":"Tancredi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumire","family":"Sakabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliseu Alves","family":"Waldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,5]]},"reference":[{"key":"7232_CR1","unstructured":"World Health Organization. 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All the ethical statements (ethical approval, informed consent and guidelines) were performed and the Committee waived the need of informed consent. We declare that informed consent was not required and obtained as it is a retrospective study. All methods were performed in accordance with the relevant guidelines and regulations and ethics committee directions.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"223"}}