{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:04:06Z","timestamp":1793232246287,"version":"4.5.0"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Cutibacterium modestum<\/jats:italic>was named in 2020.<jats:italic>C. modestum<\/jats:italic>was previously called<jats:italic>Propionibacterium humerusii<\/jats:italic>. Several implant-associated infections caused by Cutibacterium species have been previously reported, but native vertebral osteomyelitis due to these bacteria has rarely been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 72-year-old man, who had previously received several nerve block injections for low back pain, was referred to our hospital for deterioration in back pain in the last 1\u00a0month. MRI findings were suggestive of L5-S1 vertebral osteomyelitis. Blood cultures and bone biopsy culture revealed the presence of Gram-positive bacilli. The isolate was identified as<jats:italic>C. modestum<\/jats:italic>by 16SrRNA gene sequencing. A diagnosis of vertebral osteomyelitis caused by<jats:italic>C. modestum<\/jats:italic>was made. Minocycline followed by oral amoxicillin was administered for 3\u00a0months. His symptom improved and did not recur after treatment completion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A case of vertebral osteomyelitis caused by<jats:italic>C. modestum<\/jats:italic>was encountered. Although<jats:italic>C. modestum<\/jats:italic>is very similar to<jats:italic>C. acnes<\/jats:italic>, it could be accurately identified by 16SrRNA gene sequencing. This case represents the first documented<jats:italic>C. modestum<\/jats:italic>infection in humans.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12879-022-07341-2","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T12:04:12Z","timestamp":1649678652000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A case report of native vertebral osteomyelitis caused by Cutibacterium modestum"],"prefix":"10.1186","volume":"22","author":[{"given":"Taiji","family":"Koyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9947-020X","authenticated-orcid":false,"given":"Goh","family":"Ohji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iku","family":"Shirasugi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichiro","family":"Ohnuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Kusuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,11]]},"reference":[{"issue":"14","key":"7341_CR1","doi-asserted-by":"publisher","first-page":"3678","DOI":"10.1128\/JB.05036-11","volume":"193","author":"SM Butler-Wu","year":"2011","unstructured":"Butler-Wu SM, Sengupta DJ, Kittichotirat W, Matsen FA 3rd, Bumgarner RE. Genome sequence of a novel species, Propionibacterium humerusii. J Bacteriol. 2011;193(14):3678.","journal-title":"J Bacteriol"},{"issue":"Pt 3","key":"7341_CR2","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1099\/00207713-52-3-841","volume":"52","author":"M Sakamoto","year":"2002","unstructured":"Sakamoto M, Suzuki M, Umeda M, Ishikawa I, Benno Y. Reclassification of Bacteroides forsythus (Tanner et al. 1986) as Tannerella forsythensis corrig., gen. nov., comb. nov. Int J Syst Evol Microbiol. 2002;52(Pt 3):841\u20139.","journal-title":"Int J Syst Evol Microbiol"},{"issue":"9","key":"7341_CR3","doi-asserted-by":"publisher","first-page":"2152","DOI":"10.1038\/jid.2013.21","volume":"133","author":"S Fitz-Gibbon","year":"2013","unstructured":"Fitz-Gibbon S, Tomida S, Chiu BH, Nguyen L, Du C, Liu M, Elashoff D, Erfe MC, Loncaric A, Kim J, et al. Propionibacterium acnes strain populations in the human skin microbiome associated with acne. J Invest Dermatol. 2013;133(9):2152\u201360.","journal-title":"J Invest Dermatol"},{"issue":"9","key":"7341_CR4","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1038\/ismej.2015.47","volume":"9","author":"J Liu","year":"2015","unstructured":"Liu J, Yan R, Zhong Q, Ngo S, Bangayan NJ, Nguyen L, Lui T, Liu M, Erfe MC, Craft N, et al. The diversity and host interactions of Propionibacterium acnes bacteriophages on human skin. ISME J. 2015;9(9):2078\u201393.","journal-title":"ISME J"},{"issue":"4","key":"7341_CR5","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1099\/ijsem.0.004058","volume":"70","author":"I Dekio","year":"2020","unstructured":"Dekio I, Sakamoto M, Suzuki T, Yuki M, Kinoshita S, Murakami Y, Ohkuma M. Cutibacterium modestum sp. Nov., isolated from meibum of human meibomian glands, and emended descriptions of Cutibacterium granulosum and Cutibacterium namnetense. Int J Syst Evol Microbiol. 2020;70(4):2457\u201362.","journal-title":"Int J Syst Evol Microbiol"},{"issue":"4","key":"7341_CR6","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1099\/ijsem.0.003274","volume":"69","author":"I Dekio","year":"2019","unstructured":"Dekio I, McDowell A, Sakamoto M, Tomida S, Ohkuma M. Proposal of new combination, Cutibacterium acnes subsp. elongatum comb. Nov., and emended descriptions of the genus Cutibacterium, Cutibacterium acnes subsp. acnes and Cutibacterium acnes subsp. defendens. Int J Syst Evol Microbiol. 2019;69(4):1087\u201392.","journal-title":"Int J Syst Evol Microbiol"},{"key":"7341_CR7","doi-asserted-by":"crossref","unstructured":"Corvec S. Clinical and biological features of Cutibacterium (formerly Propionibacterium) avidum, an underrecognized microorganism. Clin Microbiol Rev. 2018;31(3):e00064-17.","DOI":"10.1128\/CMR.00064-17"},{"key":"7341_CR8","unstructured":"The European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters, version 10.0, 2020. http:\/\/www.eucast.org\/clinical_breakpoints\/."},{"issue":"8","key":"7341_CR9","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1007\/s10482-021-01589-5","volume":"114","author":"D Goldenberger","year":"2021","unstructured":"Goldenberger D, Sogaard KK, Cuenod A, Seth-Smith H, de Menezes D, Vandamme P, Egli A. Cutibacterium modestum and \u201cPropionibacterium humerusii\u201d represent the same species that is commonly misidentified as Cutibacterium acnes. Antonie Van Leeuwenhoek. 2021;114(8):1315\u201320.","journal-title":"Antonie Van Leeuwenhoek"},{"issue":"1","key":"7341_CR10","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s10096-021-04348-6","volume":"41","author":"C Torrens","year":"2022","unstructured":"Torrens C, Bellosillo B, Gibert J, Alier A, Santana F, Prim N, Corvec S. 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The patient provided written informed consent for the anonymous collection and use of her data for research purposes.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The patient signed the consent form and provided consent for publication of this report; a copy of the written consent is available for perusal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"367"}}