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Studies have shown that deficiency in vitamin D may be a significant risk factor for poor outcomes. This study aims to compare the outcome and clinical condition of patients diagnosed with COVID-19 infection considering serum vitamin D levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cross-sectional study, 202 COVID-19 patients without known cardiovascular disease (reduced ejection fraction, uncontrolled arrhythmia, pericardial effusion, cardiac block, valvular disease, or hypertension) were included. Patients were divided into three groups of insufficient (&lt;\u200930\u00a0ng\/mL), normal (30 to 50\u00a0ng\/mL), and high (&gt;\u200950\u00a0ng\/mL) serum vitamin D levels. Clinical outcome was defined as severe if invasive respiratory intervention and ICU admission was required.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The patients were divided into three groups based on their vitamin D level: 127 cases in the insufficient vitamin D group, 53 cases in the normal vitamin D group, and 22 cases in the high vitamin D group. The mean age of the population study was 56\u00a0years. Thirty-four patients had severe clinical outcomes. The distribution of this group was as follows: 21 patients in the insufficient vitamin D group (16.5%), eight patients in the normal vitamin D group (15.1%), and five patients in the high vitamin D group (22.7%); P\u2009=\u20090.74. No significant differences were found between the groups in terms of mortality rate (P\u2009=\u20090.46). Moreover, the mean of leukocytes (mean\u2009\u00b1\u2009SD\u2009=\u20096873.5\u2009\u00b1\u20094236.2), ESR (mean\u2009\u00b1\u2009SD\u2009=\u200938.42\u2009\u00b1\u200926.7), and CPK-MB (mean\u2009\u00b1\u2009SD\u2009=\u200963\u2009\u00b1\u2009140.7) were higher in the insufficient vitamin D group, but it was not statistically significant (P\u2009&gt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The finding of the present study showed that vitamin D could not make a significant difference in cardiovascular systems, laboratory results, and severity of the disease in COVID-19 patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12879-022-07438-8","type":"journal-article","created":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T08:05:08Z","timestamp":1651910708000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of the cardiovascular system, clinical condition, and laboratory results in COVID-19 patients with and without vitamin D insufficiency"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3886-0466","authenticated-orcid":false,"given":"Erfan","family":"Kazemi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7206-2858","authenticated-orcid":false,"given":"Ali","family":"Mansoursamaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7945-7542","authenticated-orcid":false,"given":"Marzieh","family":"Rohani-Rasaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1632-0511","authenticated-orcid":false,"given":"Hossein","family":"Sheibani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,5,7]]},"reference":[{"issue":"9","key":"7438_CR1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0239799","volume":"15","author":"Z Maghbooli","year":"2020","unstructured":"Maghbooli Z, et al. 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