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There has been much research on immunological and clinical pathological changes associated with <jats:italic>S. scabiei<\/jats:italic> parasitism across a range of host species. This rich body of literature is complex, and we seek to bring that complexity together in this study. We first (1) synthesise narrative reviews of immunopathological relationships to <jats:italic>S. scabiei<\/jats:italic> infection to construct overarching hypotheses; then (2) undertake a systematic meta-analysis of primary literature on immunological and clinical pathological changes; and lastly (3) contrast our findings from the meta-analysis to our synthesis from narrative reviews.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We synthesised 55 narrative reviews into two overarching hypotheses representing type I and type IV immune responses to <jats:italic>S. scabiei<\/jats:italic> infection. We then systematically extracted all literature reporting immunological variables, acute phase proteins, oxidant\/antioxidant status, and erythrocytic, hepatological and nephrological changes, calculating 565 effect sizes between controls and sarcoptic mange affected groupings, refining (simplifying) hypotheses from narrative reviews.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Immunological and clinical pathological parameters were most often studied in dogs (n\u2009=\u200912) and humans (n\u2009=\u200914). Combining immunological and clinical pathological information across mammalian species (n\u2009=\u200919) helped yield general insights into observed disease responses. This is evidenced by interspecific consensus in 27 immunological and clinical pathology variables (6\/26 type I hypersensitivity, 3\/20 type IV hypersensitivity, 6\/10 oxidant\/antioxidant status, 3\/6 acute phase protein, 4\/7 erythrocytic, and 5\/10 hepatological\/nephrological).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Elevated IgE, eosinophils and mast cells in type I hypersensitivity response corresponded to what was described in narrative reviews. Results from type IV hypersensitivity response suggested typical antibody response, however cell-mediated response was less evident. Some consensus of acute phase protein response and shifted oxidant\/antioxidant balance and slight evidence of anemia. We highlight the need for mange\/scabies studies to more routinely compare immunological and clinical pathological changes against controls, and include collection of a more standardised suite of variables among studies.\n<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-022-07635-5","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T17:03:24Z","timestamp":1659027804000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Evidence underscoring immunological and clinical pathological changes associated with Sarcoptes scabiei infection: synthesis and meta-analysis"],"prefix":"10.1186","volume":"22","author":[{"given":"Christina","family":"N\u00e6sborg-Nielsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Mejia-Pacheco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Carver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,28]]},"reference":[{"key":"7635_CR1","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1111\/tbed.14082","volume":"69","author":"LE Escobar","year":"2021","unstructured":"Escobar LE, Carver S, Cross PC, Rossi L, Almberg ES, Yabsley MJ, et al. 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