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Our previous research proved that Sjogren\u2019s syndrome (SS) is a predisposing factor for CRS, with a 2.5-fold associated risk. Antibiotics are important in CRS treatment; however, there is a paucity of research on the pathogenic bacteria of SS-CRS in the past. We conducted this study to investigate the pathogenic difference of SS-CRS and non-SS-CRS and aimed to give clinicians references when selecting antibiotics to treat SS-CRS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>A total of 14,678 patients hospitalized for CRS operation from 2004 to 2018 were identified from the Chang Gung Research Database. These CRS cases were classified as either SS-CRS or non-SS-CRS. We analyzed their bacterial distribution by studying the results of the pus cultures performed alongside surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The top three facultative anaerobic or aerobic isolated bacteria in the SS-CRS group were coagulase-negative <jats:italic>Staphylococcus<\/jats:italic> (CoNS: 34.3%), <jats:italic>Pseudomonas aeruginosa<\/jats:italic> (28.6%), methicillin-sensitive <jats:italic>Staphylococcus aureus<\/jats:italic> (MSSA: 20%), and <jats:italic>Staphylococcus epidermidis<\/jats:italic> (20%). In the non-SS-CRS group, S. <jats:italic>epidermidis<\/jats:italic> (29.3%), CoNS (25.7%), and MSSA (14.2%) were identified. The top three anaerobic bacterial genera were <jats:italic>Cutibacterium<\/jats:italic> (54.3%), <jats:italic>Peptostreptococcus<\/jats:italic> (11.4%), and <jats:italic>Fusobacterium<\/jats:italic> (11.4%) in the SS-CRS group and <jats:italic>Cutibacterium<\/jats:italic> (53.8%), <jats:italic>Peptostreptococcus<\/jats:italic> (25%), and <jats:italic>Prevotella<\/jats:italic> (12.9%) in the non-SS-CRS group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p><jats:italic>P.<\/jats:italic><jats:italic>aeruginosa<\/jats:italic> is a major pathogen in SS-CRS patients. In addition, physicians should be aware of potential <jats:italic>Fusobacterium<\/jats:italic> and antibiotic-resistant bacterial infection in patients with SS-CRS.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-022-07652-4","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T03:30:59Z","timestamp":1659411059000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The difference in pathogenic bacteria between chronic rhinosinusitis in patients with and without Sjogren\u2019s syndrome: a retrospective case\u2013control study"],"prefix":"10.1186","volume":"22","author":[{"given":"Pei-Rung","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Tai","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Hsu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Yen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Shao","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Te","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Ming","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Yuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pey-Jium","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng-He","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"issue":"Suppl_S29","key":"7652_CR1","first-page":"1","volume":"58","author":"WJ Fokkens","year":"2020","unstructured":"Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R, Reitsma S, Toppila-Salmi S, Bernal-Sprekelsen M, Mullol J, Alobid I, et al. 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