{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:14:42Z","timestamp":1772118882613,"version":"3.50.1"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007322","name":"Binzhou Medical University","doi-asserted-by":"publisher","award":["BY2015KYQD23"],"award-info":[{"award-number":["BY2015KYQD23"]}],"id":[{"id":"10.13039\/501100007322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007322","name":"Binzhou Medical University","doi-asserted-by":"publisher","award":["BY2015KJ01"],"award-info":[{"award-number":["BY2015KJ01"]}],"id":[{"id":"10.13039\/501100007322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010669","name":"Department of Health of Shandong Province","doi-asserted-by":"publisher","award":["2019-0515"],"award-info":[{"award-number":["2019-0515"]}],"id":[{"id":"10.13039\/501100010669","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p><jats:italic>Vibrio vulnificus<\/jats:italic> infections develop rapidly and are associated with a high mortality rate. The rates of diagnosis and treatment are directly associated with mortality.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We describe an unusual case of a 61-year-old male patient with chronic liver disease and diabetes who presented with a chief complaint of pain in both lower legs due to <jats:italic>V. vulnificus<\/jats:italic> infection in winter. Within 12\u00a0h of arrival, typical skin lesions appeared, and the patient rapidly developed primary sepsis. Despite prompt appropriate antibiotic and surgical treatment, the patient died 16\u00a0days after admission.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our case findings suggest that <jats:italic>V. vulnificus<\/jats:italic> infection should be suspected in patients with an unclear infection status experiencing pain of unknown origin in the lower legs, particularly in patients with liver disease or diabetes, immunocompromised status, and alcoholism.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-022-07655-1","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T08:06:07Z","timestamp":1659600367000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Vibrio vulnificus necrotizing fasciitis with sepsis presenting with pain in the lower legs in winter: a case report"],"prefix":"10.1186","volume":"22","author":[{"given":"Weihua","family":"Di","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanlan","family":"Sa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingjin","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guofeng","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuijie","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7203-7377","authenticated-orcid":false,"given":"Yong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,8,4]]},"reference":[{"key":"7655_CR1","doi-asserted-by":"publisher","first-page":"721","DOI":"10.3109\/00365548909021703","volume":"21","author":"YC Chuang","year":"1989","unstructured":"Chuang YC, Young CD, Chen CW. Vibrio vulnificus infection. Scand J Infect Dis. 1989;21:721\u20136.","journal-title":"Scand J Infect Dis"},{"key":"7655_CR2","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1128\/jcm.3.4.425-431.1976","volume":"3","author":"DG Hollis","year":"1976","unstructured":"Hollis DG, Weaver RE, Baker CN, Thornsberry C. Halophilic Vibrio species isolated from blood cultures. J Clin Microbiol. 1976;3:425\u201331.","journal-title":"J Clin Microbiol"},{"key":"7655_CR3","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1128\/AEM.64.4.1459-1465.1998","volume":"64","author":"ML Motes","year":"1998","unstructured":"Motes ML, DePaola A, Cook DW, Veazey JE, Hunsucker JC, Garthright WE, et al. Influence of water temperature and salinity on Vibrio vulnificus in Northern Gulf and Atlantic Coast oysters (Crassostrea virginica). 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A copy of the written consent is available for review by the Editor of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"670"}}