{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:52:37Z","timestamp":1775782357151,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T00:00:00Z","timestamp":1660953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T00:00:00Z","timestamp":1660953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p><jats:italic>Campylobacter jejuni<\/jats:italic> is a common cause of acute gastroenteritis, but central nervous system infections are rare manifestations of <jats:italic>Campylobacter<\/jats:italic> infection. Therefore, <jats:italic>C. jejuni<\/jats:italic> trauma-related subdural hygroma infection in children is poorly described in the literature.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We described a 2-year old boy with lobar holoprosencephaly presenting with subdural hygroma following head trauma. <jats:italic>C. jejuni<\/jats:italic> infection was confirmed from a subdural hygroma sample by culture as well as by DNA sequencing of a broad range 16S rDNA PCR product. Cerebrospinal fluid from the ventriculoperitoneal shunt remained sterile. Combined neurosurgical and antimicrobial treatment led to complete recovery. Review of the literature showed that the most common manifestation of <jats:italic>Campylobacter<\/jats:italic> central nervous system infection is meningitis, mostly in neonates, and subdural hygroma infection was described for only one case.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Subdural hygroma infection caused by <jats:italic>C. jejuni<\/jats:italic> is a rare clinical condition in children. Molecular methods represent an important tool for the detection of rare or unexpected pathogens. No standard recommendations for antimicrobial treatment of <jats:italic>C. jejuni<\/jats:italic> subdural space infection in children are available, but meropenem treatment combined with surgery seems to be an effective approach.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-022-07680-0","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T06:03:41Z","timestamp":1660975421000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Campylobacter jejuni subdural hygroma infection in a 2-year old boy: case report and a brief literature review"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1523-1031","authenticated-orcid":false,"given":"Ivana","family":"Valen\u010dak-Ignjati\u0107","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Krajcar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Didovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sr\u0111an","family":"Rogli\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iva","family":"Buti\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Jeli\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hrvoje","family":"Jedna\u010dak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goran","family":"Te\u0161ovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,8,20]]},"reference":[{"key":"7680_CR1","volume-title":"Mandell, Douglas, And Bennett\u2019s principles and practice of infectious diseases","author":"JE Bennett","year":"2019","unstructured":"Bennett JE, Dolin R, Blaser MJ. 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This article does not contain any studies with animals performed by any of the authors. The study was approved by the Ethics Committee of the University Hospital for Infectious Diseases \u201cDr. Fran Mihaljevi\u0107\u201d, Zagreb (Ethics Committee approval number 01-1931-6-2020). Informed consent was obtained from legal guardians.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Legal guardians signed informed consent regarding publishing patients data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"700"}}