{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:09:16Z","timestamp":1791950956494,"version":"4.3.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Early identification of bloodstream pathogens and their associated antimicrobial resistance may shorten time to optimal therapy in patients with sepsis. The BioFire Blood Culture Identification 2 Panel (BCID2) is a novel multiplex PCR detecting 43 targets directly from positive blood cultures, reducing turnaround times.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We have performed a systematic review and meta-analysis of diagnostic test accuracy studies to assess the BCID2 performance for pathogen identification and resistance markers detection compared to gold standard culture-based methods (including phenotypic and\/or genotypic characterization).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Nine studies were identified reporting data to build 2\u2009\u00d7\u20092 tables for each BCID2 target, including 2005 blood cultures. The pooled specificity of the assay was excellent (&gt;\u200997%) across most subgroups of targets investigated, with a slightly broader confidence interval for <jats:italic>S. epidermidis<\/jats:italic> (98.1%, 95% CI 93.1 to 99.5). Pooled sensitivity was also high for the major determinants of bloodstream infection, including <jats:italic>Enterobacterales<\/jats:italic> (98.2%, 95% CI 96.3 to 99.1)<jats:italic>, S. aureus<\/jats:italic> (96.0%, 95% CI 90.4 to 98.4)<jats:italic>, Streptococcus spp<\/jats:italic>. (96.7%, 95% CI 92.8 to 98.5), <jats:italic>P. aeruginosa<\/jats:italic> (92.7%, 95% CI 83.1 to 97.0), <jats:italic>E. faecalis<\/jats:italic> (92.3%, 95% CI 83.5 to 96.6), as well as <jats:italic>bla<\/jats:italic><jats:sub>CTX-M<\/jats:sub> (94.9, 95% CI 85.7 to 98.3), carbapenemases (94.9%, 95% CI 83.4 to 98.6) and <jats:italic>mecA\/C &amp; MREJ<\/jats:italic> (93.9%, 95% CI 83.0 to 98.0). Sensitivity for less common targets was slightly lower, possibly due to their under-representation in the included studies.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>BCID2 showed good performance for detecting major determinants of bloodstream infection and could support early antimicrobial treatment, especially for ESBL or carbapenemase-producing Gram-negative bacilli and methicillin-resistant <jats:italic>S. aureus<\/jats:italic>.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-022-07772-x","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T12:05:54Z","timestamp":1666267554000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Performance of BioFire Blood Culture Identification 2 Panel (BCID2) for the detection of bloodstream pathogens and their associated resistance markers: a systematic review and meta-analysis of diagnostic test accuracy studies"],"prefix":"10.1186","volume":"22","author":[{"given":"Anna Maria","family":"Peri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Furuya-Kanamori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick N. 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The other authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"794"}}