{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T01:08:35Z","timestamp":1784509715284,"version":"3.55.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T00:00:00Z","timestamp":1667606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T00:00:00Z","timestamp":1667606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Herpes simplex virus (HSV) rarely causes organ-invasive infection. Diagnosis and treatment for such infections are often delayed, and mortality is high. We present the first reported case of disseminated HSV-1 infection in an adult causing liver failure, myocarditis, and encephalitis in a patient who recovered after receiving parenteral acyclovir treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 46-year-old female presented with fever, chills, and malaise after 2 weeks of oral corticosteroid treatment for uveitis. She was diagnosed with disseminated HSV-1 infection with multi-organ involvement causing hepatitis, encephalitis, and myocarditis. Diagnosis was made timely using serum polymerase chain reaction (PCR) for HSV DNA and the patient was given intravenous acyclovir treatment promptly, which led to her survival without significant morbidity.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Clinicians should have a low threshold for suspecting HSV infection and ordering HSV PCR to decrease morbidity and mortality when there is a high clinical suspicion of systemic HSV infection with multi-organ involvement. Serum PCR for HSV DNA is an excellent modality for an initial diagnostic approach. Further research is warranted to elucidate causality between a course of corticosteroid therapy and systemic HSV-1 infection without major immunosuppressive comorbidities or treatments.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-022-07815-3","type":"journal-article","created":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T06:02:31Z","timestamp":1667628151000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A case report of severe systemic herpes simplex virus-1 (HSV-1) infection with multi-organ involvement after a course of oral corticosteroid treatment"],"prefix":"10.1186","volume":"22","author":[{"given":"Myeongji","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Jalal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heysu","family":"Rubio-Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Bromberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,5]]},"reference":[{"key":"7815_CR1","unstructured":"Whitley RJ. Herpesviruses. In: Baron S, editor. Medical microbiology. 4th edition. Galveston (TX): University of Texas Medical Branch at Galveston; 1996. Chapter 68."},{"issue":"11","key":"7815_CR2","first-page":"2239","volume":"93","author":"K Kurahara","year":"1998","unstructured":"Kurahara K, Aoyagi K, Nakamura S, Kuwano Y, Yamamoto C, Iida M, Fujishima M. Treatment of herpes simplex esophagitis in an immunocompetent patient with intravenous acyclovir: a case report and review of the literature. Am J Gastroenterol. 1998;93(11):2239\u201340.","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"7815_CR3","first-page":"e21854","volume":"14","author":"R Ohta","year":"2022","unstructured":"Ohta R, Sano C. A rare case of herpes esophagitis in an immunocompetent elderly patient. 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Herpes simplex virus pneumonia mimicking Legionella pneumonia in an elderly patient with heart and liver failure. Cureus. 2022;14(2):e21938.","journal-title":"Cureus"},{"issue":"10","key":"7815_CR7","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1002\/lt.21250","volume":"13","author":"JP Norvell","year":"2007","unstructured":"Norvell JP, Blei AT, Jovanovic BD, Levitsky J.\u00a0Herpes simplex virus hepatitis: an analysis of the\npublished literature and institutional cases.\u00a0Liver Transpl. 2007;13(10):1428\u201334.","journal-title":"Liver Transpl"},{"issue":"3","key":"7815_CR8","doi-asserted-by":"publisher","first-page":"235","DOI":"10.2174\/187152611795768088","volume":"11","author":"F Rozenberg","year":"2011","unstructured":"Rozenberg F, Deback C, Agut H. Herpes simplex encephalitis: from virus to therapy. 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A copy of the written consent is available for review by the Editor-in-Chief of this journal on request.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they do not have any conflict of interest that should be disclosed.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"817"}}