{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T23:42:39Z","timestamp":1774654959946,"version":"3.50.1"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Fungal periprosthetic joint infections are rare. <jats:italic>Acremonium<\/jats:italic> osteoarticular infections are scarcely reported. Variable susceptibility to antifungal agents have been reported and optimal pharmacotherapy has yet to be established. Here we illustrate an <jats:italic>Acremonium<\/jats:italic> osteoarticular infection involving a prosthetic joint and present an antifungal regimen that had led to treatment success.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 60-year-old female with a body mass index (BMI) of 40 had left total knee arthroplasty done in 2012 with a cementless implant for knee osteoarthritis. In 2019, the patient had asymptomatic, progressive osteolysis with fracture and migration of the femoral component warranting replacement. Eleven months later, the patient developed significant pain, redness, and swelling in the left leg and knee concerning for periprosthetic joint infection that failed outpatient antibiotic treatment. Further investigation revealed infection by <jats:italic>Acremonium<\/jats:italic> species. A revision of the joint was successfully completed, and the patient was placed on voriconazole for one year. Subsequent cultures did not yield any fungal growth.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>While an optimal antifungal regimen for periprosthetic joint infections has not been well established, voriconazole is a relatively safe and effective agent that can be used as a long-term therapy. With variable susceptibility testing in reported isolates, individualized antifungal susceptibility should be used to guide therapy for <jats:italic>Acremonium<\/jats:italic> infections.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-022-07824-2","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T06:02:46Z","timestamp":1672293766000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Acremonium (Sarocladium) periprosthetic joint infection: case report, literature review, and proposed antifungal regimen"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5596-9749","authenticated-orcid":false,"given":"Nikko Rowe A.","family":"Tabliago","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Maish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel M.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Shelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bridget","family":"Yablonski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taesung","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"issue":"Suppl 6","key":"7824_CR1","doi-asserted-by":"publisher","first-page":"142","DOI":"10.2106\/JBJS.I.00574","volume":"91","author":"K Azzam","year":"2009","unstructured":"Azzam K, et al. Microbiological, clinical, and surgical features of fungal prosthetic joint infections: a multi-institutional experience. J Bone Jt Surg Am. 2009;91(Suppl 6):142\u20139.","journal-title":"J Bone Jt Surg Am"},{"issue":"1","key":"7824_CR2","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1128\/JCM.00793-10","volume":"49","author":"H Perdomo","year":"2011","unstructured":"Perdomo H, et al. Spectrum of clinically relevant Acremonium species in the United States. J Clin Microbiol. 2011;49(1):243\u201356.","journal-title":"J Clin Microbiol"},{"key":"7824_CR3","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3767\/003158515X685364","volume":"34","author":"A Giraldo","year":"2015","unstructured":"Giraldo A, et al. Phylogeny of Sarocladium (Hypocreales). Persoonia. 2015;34:10\u201324.","journal-title":"Persoonia"},{"issue":"4","key":"7824_CR4","first-page":"714","volume":"15","author":"SP Szombathy","year":"1988","unstructured":"Szombathy SP, Chez MG, Laxer RM. Acute septic arthritis due to Acremonium. J Rheumatol. 1988;15(4):714\u20135.","journal-title":"J Rheumatol"},{"issue":"50","key":"7824_CR5","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002078","volume":"94","author":"SJ Taj-Aldeen","year":"2015","unstructured":"Taj-Aldeen SJ, et al. Osteoarticular infections caused by non-aspergillus filamentous fungi in adult and pediatric patients: a systematic review. Medicine (Baltimore). 2015;94(50): e2078.","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"7824_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/cid\/cis966","volume":"56","author":"DR Osmon","year":"2013","unstructured":"Osmon DR, et al. Executive summary: diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis. 2013;56(1):1\u201310.","journal-title":"Clin Infect Dis"},{"issue":"5","key":"7824_CR7","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1016\/j.arth.2018.02.078","volume":"33","author":"J Parvizi","year":"2018","unstructured":"Parvizi J, et al. The 2018 definition of periprosthetic hip and knee infection: an evidence-based and validated criteria. J Arthroplasty. 2018;33(5):1309-1314 e2.","journal-title":"J Arthroplasty"},{"issue":"11","key":"7824_CR8","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1111\/myc.13169","volume":"63","author":"A Perez-Cantero","year":"2020","unstructured":"Perez-Cantero A, Guarro J. Sarocladium and Acremonium infections: new faces of an old opportunistic fungus. Mycoses. 2020;63(11):1203\u201314.","journal-title":"Mycoses"},{"issue":"1","key":"7824_CR9","doi-asserted-by":"publisher","first-page":"158","DOI":"10.3109\/1040841X.2014.910749","volume":"42","author":"P Koehler","year":"2016","unstructured":"Koehler P, Tacke D, Cornely OA. Bone and joint infections by Mucorales, Scedosporium, Fusarium and even rarer fungi. Crit Rev Microbiol. 2016;42(1):158\u201371.","journal-title":"Crit Rev Microbiol"},{"issue":"6","key":"7824_CR10","doi-asserted-by":"publisher","first-page":"656","DOI":"10.5301\/hipint.5000205","volume":"24","author":"CY Wu","year":"2014","unstructured":"Wu CY, et al. Acremonium species combined with Penicillium species infection in hip hemiarthroplasty: a case report and literature review. Hip Int. 2014;24(6):656\u20139.","journal-title":"Hip Int"},{"issue":"5","key":"7824_CR11","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1086\/516098","volume":"25","author":"J Guarro","year":"1997","unstructured":"Guarro J, et al. Acremonium species: new emerging fungal opportunists\u2014in vitro antifungal susceptibilities and review. Clin Infect Dis. 1997;25(5):1222\u20139.","journal-title":"Clin Infect Dis"},{"issue":"1","key":"7824_CR12","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1128\/CMR.00046-13","volume":"27","author":"T Felton","year":"2014","unstructured":"Felton T, Troke PF, Hope WW. Tissue penetration of antifungal agents. Clin Microbiol Rev. 2014;27(1):68\u201388.","journal-title":"Clin Microbiol Rev"},{"issue":"7","key":"7824_CR13","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1136\/bjo.2007.136515","volume":"92","author":"SM Hariprasad","year":"2008","unstructured":"Hariprasad SM, et al. Voriconazole in the treatment of fungal eye infections: a review of current literature. Br J Ophthalmol. 2008;92(7):871\u20138.","journal-title":"Br J Ophthalmol"},{"issue":"5","key":"7824_CR14","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1093\/jac\/dkt508","volume":"69","author":"HR Ashbee","year":"2014","unstructured":"Ashbee HR, et al. Therapeutic drug monitoring (TDM) of antifungal agents: guidelines from the British Society for Medical Mycology. J Antimicrob Chemother. 2014;69(5):1162\u201376.","journal-title":"J Antimicrob Chemother"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-022-07824-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12879-022-07824-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-022-07824-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T10:03:12Z","timestamp":1672567392000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-022-07824-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,29]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["7824"],"URL":"https:\/\/doi.org\/10.1186\/s12879-022-07824-2","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,29]]},"assertion":[{"value":"1 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors have obtained written consent for publication of this information from the study participant.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"964"}}