{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:58:31Z","timestamp":1792648711285,"version":"4.5.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Bloodstream infections caused by\n                      <jats:italic>Candida<\/jats:italic>\n                      species are responsible for significant morbidity and mortality worldwide, with an ever-changing epidemiology. We conducted this study to assess trends in the epidemiologic features, risk factors and\n                      <jats:italic>Candida<\/jats:italic>\n                      species distribution in candidemia patients in Alameda County, California.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data collected from patients in Alameda County, California between 2017 and 2020 as part of the California Emerging Infections Program (CEIP). This is a laboratory-based, active surveillance program for candidemia. In our study, we included incident cases only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the 4-year period from January 1st, 2017, to December 31st, 2020, 392 incident cases of candidemia were identified. The mean crude annual cumulative incidence was 5.9 cases per 100,000 inhabitants (range 5.0\u20136.5 cases per 100,000 population).\n                      <jats:italic>Candida glabrata<\/jats:italic>\n                      was the most common\n                      <jats:italic>Candida<\/jats:italic>\n                      species and was present as the only\n                      <jats:italic>Candida<\/jats:italic>\n                      species in 149 cases (38.0%), followed by\n                      <jats:italic>Candida albicans<\/jats:italic>\n                      , 130 (33.2%). Mixed\n                      <jats:italic>Candida<\/jats:italic>\n                      species were present in 13 patients (3.3%). Most of the cases of candidemia occurred in individuals with one or more underlying conditions. Multivariate regression models showed that age \u2265\u200965\u00a0years (RR 1.66, CI 1.28\u20132.14), prior administration of systemic antibiotic therapy, (RR 1.84, CI 1.06\u20133.17), cirrhosis of the liver, (RR 2.01, CI 1.51\u20132.68), and prior admission to the ICU (RR1.82, CI 1.36\u20132.43) were significant predictors of mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Non-albicans\n                      <jats:italic>Candida<\/jats:italic>\n                      species currently account for the majority of candidemia cases in Alameda County.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12879-022-07848-8","type":"journal-article","created":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T01:02:31Z","timestamp":1668214951000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Epidemiologic features, clinical characteristics, and predictors of mortality in patients with candidemia in Alameda County, California; a 2017\u20132020 retrospective analysis"],"prefix":"10.1186","volume":"22","author":[{"given":"Didien","family":"Meyahnwi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bekure B.","family":"Siraw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Reingold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,12]]},"reference":[{"issue":"Suppl 7","key":"7848_CR1","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/1469-0691.12039","volume":"18","author":"OA Cornely","year":"2012","unstructured":"Cornely OA, Bassetti M, Calandra T, et al. 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The CEIP obtained informed consent from all study participants. For participants under the age of 16, informed consent was obtained from a parent and\/or legal guardian. The CEIP Institutional Review Board approved our study and provided us with de-identified data for our analysis. There was no direct human involvement in our study. All study procedures were carried out in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflicts of interest related to this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"843"}}