{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T10:53:09Z","timestamp":1740135189170,"version":"3.37.3"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:00:00Z","timestamp":1670544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:00:00Z","timestamp":1670544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100017590","name":"Universit\u00e4tsklinikum Essen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100017590","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p><jats:italic>Mycobacterium (M.) chimaera<\/jats:italic> is a non-tuberculous mycobacterium (NTM) that belongs to <jats:italic>M. avium complex<\/jats:italic> (MAC). In patients with cystic fibrosis (CF), MAC can cause bronchopulmonary infections that can be prolonged and difficult to treat. MAC infections of sites other than the lungs or central catheters are rare and almost exclusively associated with immunodeficiency.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We present a case of an 8-year-old CF patient (delF508 homozygous) with recurrent pulmonary exacerbations, gradual clinical deterioration, B-symptoms (fever, fatigue, weight loss, night sweat), elevated transaminases and intermittent detection of <jats:italic>M. chimaera<\/jats:italic> in the sputum without radiological signs of NTM-associated lung disease with a central venous port-catheter. Next-generation sequencing (NGS) revealed <jats:italic>M. chimaera<\/jats:italic> port infection that was also confirmed by mycobacterial culture. The patient recovered within 4\u00a0weeks after removal of the catheter and initiation of MAC targeted antimicrobial therapy. Electron microscopy of the catheter illustrated the presence of mycobacteria in a biofilm.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>MAC central venous catheter infection needs to be considered in immunocompetent people. NGS is a valuable tool for rapid identification of rare infections. MAC capability of biofilm formation renders catheter removal the central therapeutic intervention for the clearance of the infection.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-022-07899-x","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T09:03:14Z","timestamp":1670576594000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Biofilm infection of a central venous port-catheter caused by Mycobacterium avium complex in an immunocompetent child with cystic fibrosis"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2388-4043","authenticated-orcid":false,"given":"Alexandra","family":"Kavvalou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Stehling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Tschiedel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Kehrmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Walkenfort","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Hasenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarete","family":"Olivier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathis","family":"Steindor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,9]]},"reference":[{"issue":"4","key":"7899_CR1","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1099\/ijs.0.02777-0","volume":"54","author":"E Tortoli","year":"2004","unstructured":"Tortoli E, Rindi L, Garcia MJ, Chiaradonna P, Dei R, Garzelli C, et al. Proposal to elevate the genetic variant MAC-A, included in the Mycobacterium avium complex, to species rank as Mycobacterium chimaera sp. nov. Int J Syst Evol Microbiol. 2004;54(4):1277\u201385.","journal-title":"Int J Syst Evol Microbiol"},{"key":"7899_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.586657","volume":"11","author":"AD Siddam","year":"2020","unstructured":"Siddam AD, Zaslow SJ, Wang Y, Phillips KS, Silverman MD, Regan PM, et al. Characterization of biofilm formation by Mycobacterium chimaera on medical device materials. Front Microbiol. 2020;11: 586657.","journal-title":"Front Microbiol"},{"issue":"6","key":"7899_CR3","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1128\/JCM.00186-13","volume":"51","author":"RJ Wallace Jr","year":"2013","unstructured":"Wallace RJ Jr, Iakhiaeva E, Williams MD, Brown-Elliott BA, Vasireddy S, Vasireddy R, et al. Absence of Mycobacterium intracellulare and presence of Mycobacterium chimaera in household water and biofilm samples of patients in the United States with Mycobacterium avium complex respiratory disease. J Clin Microbiol. 2013;51(6):1747\u201352.","journal-title":"J Clin Microbiol"},{"issue":"2","key":"7899_CR4","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1097\/PAS.0000000000001179","volume":"43","author":"N Shafizadeh","year":"2019","unstructured":"Shafizadeh N, Hale G, Bhatnagar J, Alshak NS, Nomura J. Mycobacterium chimaera hepatitis: a new disease entity. Am J Surg Pathol. 2019;43(2):244\u201350.","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"7899_CR5","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/S1473-3099(17)30324-9","volume":"17","author":"J van Ingen","year":"2017","unstructured":"van Ingen J, Kohl TA, Kranzer K, Hasse B, Keller PM, Katarzyna Szafranska A, et al. 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A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"921"}}