{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:40:58Z","timestamp":1793133658581,"version":"4.5.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Enterprises and the Basic and applied Basic Research Foundation of Guangdong Province","award":["2022A1515220169"],"award-info":[{"award-number":["2022A1515220169"]}]},{"name":"Enterprises and the Basic and applied Basic Research Foundation of Guangdong Province","award":["2022A1515220169"],"award-info":[{"award-number":["2022A1515220169"]}]},{"name":"Enterprises and the Basic and applied Basic Research Foundation of Guangdong Province","award":["2022A1515220169"],"award-info":[{"award-number":["2022A1515220169"]}]},{"name":"Enterprises and the Basic and applied Basic Research Foundation of Guangdong Province","award":["2022A1515220169"],"award-info":[{"award-number":["2022A1515220169"]}]},{"name":"Enterprises and the Basic and applied Basic Research Foundation of Guangdong Province","award":["2022A1515220169"],"award-info":[{"award-number":["2022A1515220169"]}]},{"name":"Enterprises and the Basic and applied Basic Research Foundation of Guangdong Province","award":["2022A1515220169"],"award-info":[{"award-number":["2022A1515220169"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Leptospirosis is a zoonosis caused by spirochete \u201cgenus\u201d leptospira. The clinical presentations of leptospirosis range from an influenza-like presentation of fever and myalgia, to severe forms. Leptospirosis can potentially lead to a misdiagnosis or delay in diagnosis when clinical similarities exist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 63-year-old man presented with fever, shock and thrombocytopenia followed by diffuse pulmonary hemorrhage. Peripheral blood Metagenomic Next-generation Sequencing (mNGS) reported Leptospira interrogans. The patient was treated with piperacillin-tazobactam (TZP) plus doxycycline and improved dramatically after 7 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We conclude that leptospirosis can potentially lead to a misdiagnosis or delay in diagnosis. Correctly evaluation of thrombocytopenia in acute febrile illnesses facilitates the differential diagnosis of leptospirosis. mNGS can accurately detect Leptospira DNA during the early stage of the infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12879-023-08367-w","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T10:02:37Z","timestamp":1690797757000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A rare case of severe leptospirosis infection presenting as septic shock in a non-endemic area: a case report and literature review"],"prefix":"10.1186","volume":"23","author":[{"given":"Junjie","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaxiang","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongchang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,31]]},"reference":[{"issue":"5","key":"8367_CR1","doi-asserted-by":"publisher","first-page":"e0007270","DOI":"10.1371\/journal.pntd.0007270","volume":"13","author":"AT Vincent","year":"2019","unstructured":"Vincent AT, Schiettekatte O, Goarant C, et al. 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