{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T10:38:47Z","timestamp":1781174327634,"version":"3.54.1"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:00:00Z","timestamp":1693958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:00:00Z","timestamp":1693958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      To date, few cases of TSS caused by coagulase negative (CoN)\n                      <jats:italic>staphylococci<\/jats:italic>\n                      have been reported in the literature. Recent data show that CoN\n                      <jats:italic>staphylococci<\/jats:italic>\n                      are capable of secreting a number of enterotoxins and cytotoxins, normally produced by\n                      <jats:italic>S. aureus<\/jats:italic>\n                      . Herewith, we describe a case of TSS caused by\n                      <jats:italic>Staphylococcus epidermidis<\/jats:italic>\n                      with a favorable outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>\n                      We report a case of a 46-year-old man who developed TSS from\n                      <jats:italic>S. epidermidis<\/jats:italic>\n                      . The patient was admitted for a 7-day history of general malaise and headache following a recent influenza infection and a 3-day history of vomiting, diarrhea, diffuse erythroderma, and fever. The main laboratory findings on admission were leukopenia (WBC 800\/mm3), thrombocytopenia (Plt count 78.000\/mm3), elevated urea, creatine levels and increased inflammatory markers (CRP 368\u00a0mg\/ml). The patient had clinical and radiological evidence of pneumonia with chest computed tomography (CT) showing diffuse bilateral airspace opacifications with air bronchogram. On the second day, a methicillin resistant\n                      <jats:italic>S. epidermidis<\/jats:italic>\n                      (MRSE) strain was detected in both sets of blood cultures, but the organism was unavailable for toxin testing. All other cultures and diagnostic PCR tests were negative. His clinical signs and symptoms fulfilled at that stage four out of five clinical criteria of TSS with a fever of 39\u00a0\u00b0C, diffuse erythroderma, multisystem involvement and hypotension. On the same day the patient was admitted to the ICU due to acute respiratory failure. The initial treatment was meropenem, vancomycin, levofloxacin, clindamycin, IVIG and steroids. Finger desquamation appeared on the 9th day of hospitalization, fulfilling all five clinical criteria for TSS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>To our knowledge, this is the first adult case with TSS induced by CoNS (MRSE) secondary to an influenza type B infection, who had favorable progression and outcome. Further research is warranted to determine how TSS is induced by the CoNS infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12879-023-08487-3","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T04:02:34Z","timestamp":1693972954000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Staphylococcus epidermidis induced toxic shock syndrome (TSS) secondary to influenza infection"],"prefix":"10.1186","volume":"23","author":[{"given":"Charis","family":"Armeftis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Ioannou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodorakis","family":"Lazarou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achilleas","family":"Giannopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efrosyni","family":"Dimitriadou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostantinos","family":"Makrides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoi Dorothea","family":"Pana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,6]]},"reference":[{"issue":"10","key":"8487_CR1","doi-asserted-by":"publisher","first-page":"3764","DOI":"10.1128\/IAI.00298-15","volume":"83","author":"A Rynda-Apple","year":"2015","unstructured":"Rynda-Apple A, Robinson KM, Alcorn JF. 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