{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:14:29Z","timestamp":1772165669537,"version":"3.50.1"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T00:00:00Z","timestamp":1693612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T00:00:00Z","timestamp":1693612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Collagenomas are rare connective tissue hamartomas composed of dermal collagen. Patients infected with human immunodeficiency virus (HIV) can present with HIV-related lipodystrophy or lipomas. There are no known associations between HIV and collagenomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>Here we describe a case of an isolated collagenoma in an HIV patient on ART. The lesion was a seven by four-centimeter subcutaneous nodule with no epidermal changes located on the occipital scalp. This lesion was excised, and histopathology showed thick and randomly arranged collagen bundles, consistent with a collagenoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case represents an isolated collagenoma presenting in a patient with HIV. It is unclear whether HIV or ART contributed to the development of this collagenoma. Treatment of collagenomas include surgical excision and intralesional corticosteroids. In addition to lipoma or lipodystrophy, it is important to keep collagenoma in the differential diagnosis in a patient presenting with an isolated large indurated subcutaneous nodule.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12879-023-08548-7","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T22:01:53Z","timestamp":1693605713000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Isolated collagenoma in an HIV-positive patient on ART: a case report"],"prefix":"10.1186","volume":"23","author":[{"given":"Kevin K.","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoud","family":"Movassaghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brittney","family":"DeClerck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maggie","family":"Chow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,9,2]]},"reference":[{"issue":"5","key":"8548_CR1","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/S0190-9622(80)80106-X","volume":"3","author":"J Uitto","year":"1980","unstructured":"Uitto J, Santa Cruz DJ, Eisen AZ. Connective tissue nevi of the skin. Clinical, genetic, and histopathologic classification of hamartomas of the collagen, elastin, and proteoglycan type. J Am Acad Dermatol. 1980;3(5):441\u201361.","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"8548_CR2","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1080\/00015550310007571","volume":"83","author":"MM Nico","year":"2003","unstructured":"Nico MM, Valente NY, Machado KA. Isolated plantar collagenoma. Acta Derm Venereol. 2003;83(2):144.","journal-title":"Acta Derm Venereol"},{"issue":"3","key":"8548_CR3","doi-asserted-by":"publisher","first-page":"447","DOI":"10.4103\/idoj.IDOJ_335_20","volume":"12","author":"S Dash","year":"2021","unstructured":"Dash S, Palit A, Mitra S, Behera B. Multidermatomal Zosteriform Collagenoma: A Rare Case Report with Dermoscopic Findings and Review of Literature. 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Dermatol Online J. 2010;16(11):3.","journal-title":"Dermatol Online J"},{"issue":"8","key":"8548_CR7","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1089\/aid.2011.0144","volume":"28","author":"FM Shebl","year":"2012","unstructured":"Shebl FM, Yu K, Landgren O, Goedert JJ, Rabkin CS. Increased levels of circulating cytokines with HIV-related immunosuppression. AIDS Res Hum Retroviruses. 2012;28(8):809\u201315.","journal-title":"AIDS Res Hum Retroviruses"},{"key":"8548_CR8","doi-asserted-by":"crossref","unstructured":"Behera V, Randive M, Sundaray S, Murty MS. Antiretroviral therapy-induced lipodystrophy. BMJ Case Rep. 2015;2015:bcr2014207090.","DOI":"10.1136\/bcr-2014-207090"},{"issue":"3","key":"8548_CR9","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s40257-019-00422-0","volume":"20","author":"K Chelidze","year":"2019","unstructured":"Chelidze K, Thomas C, Chang AY, Freeman EE. HIV-Related Skin Disease in the Era of Antiretroviral Therapy: Recognition and Management. Am J Clin Dermatol. 2019;20(3):423\u201342.","journal-title":"Am J Clin Dermatol"},{"issue":"5","key":"8548_CR10","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1097\/DAD.0000000000000638","volume":"39","author":"H Arora","year":"2017","unstructured":"Arora H, Falto-Aizpurua L, Cortes-Fernandez A, Choudhary S, Romanelli P. Connective Tissue Nevi: A Review of the Literature. Am J Dermatopathol. 2017;39(5):325\u201341.","journal-title":"Am J Dermatopathol"},{"issue":"5","key":"8548_CR11","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1111\/j.1525-1470.2009.01003.x","volume":"26","author":"K Sardana","year":"2009","unstructured":"Sardana K, Bansal S, Garg VK, Khurana N. Linear nodular collagenoma\u2013successful treatment with intralesional triamcinolone acetonide. Pediatr Dermatol. 2009;26(5):626\u20138.","journal-title":"Pediatr Dermatol"},{"issue":"5","key":"8548_CR12","first-page":"419","volume":"26","author":"S Yadav","year":"2013","unstructured":"Yadav S, Khullar G, Saikia UN, Dogra S. Isolated corymbose collagenoma responding to intralesional triamcinolone acetonide and hyaluronidase injections. Dermatol Ther. 2013;26(5):419\u201323.","journal-title":"Dermatol Ther"},{"issue":"9","key":"8548_CR13","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1111\/j.1346-8138.2010.00884.x","volume":"37","author":"C Zhao","year":"2010","unstructured":"Zhao C, Ma W, Wang Y, Sun Q. Female with eruptive collagenoma clustered in the left lateral aspect of the abdomen. 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Documentation available upon request. All identifying information has been removed from this manuscript and figures. Informed consent was obtained from the patient to publish this case report in an online open-access publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed consent was obtained from the patient to publish this case report in an online open-access publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"571"}}