{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:50:20Z","timestamp":1791996620093,"version":"4.4.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:00:00Z","timestamp":1705881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:00:00Z","timestamp":1705881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>This study aimed to explore the characteristics of carbapenem-resistant <jats:italic>Enterobacterales<\/jats:italic> (CRE) patients in the intensive care unit (ICU) in different regions of Henan Province to provide evidence for the targeted prevention and treatment of CRE.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This was a cross-sectional study. CRE screening was conducted in the ICUs of 78 hospitals in Henan Province, China, on March 10, 2021. The patients were divided into provincial capital hospitals and nonprovincial capital hospitals for comparative analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>This study involved 1009 patients in total, of whom 241 were CRE-positive patients, 92 were in the provincial capital hospital and 149 were in the nonprovincial capital hospital. Provincial capital hospitals had a higher rate of CRE positivity, and there was a significant difference in the rate of CRE positivity between the two groups. The body temperature; immunosuppressed state; transfer from the ICU to other hospitals; and use of enemas, arterial catheters, carbapenems, or tigecycline at the provincial capital hospital were greater than those at the nonprovincial capital hospital (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). However, there was no significant difference in the distribution of carbapenemase strains or enzymes between the two groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The detection rate of CRE was significantly greater in provincial capital hospitals than in nonprovincial capital hospitals. The source of the patients, invasive procedures, and use of advanced antibiotics may account for the differences. Carbapenem-resistant <jats:italic>Klebsiella pneumoniae<\/jats:italic> (CR-KPN) was the most prevalent strain. <jats:italic>Klebsiella pneumoniae carbapenemase<\/jats:italic> (KPC) was the predominant carbapenemase enzyme. The distributions of carbapenemase strains and enzymes were similar in different regions.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-024-09005-9","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T16:02:12Z","timestamp":1705939332000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["An analysis of differences in Carbapenem-resistant Enterobacterales in different regions: a multicenter cross-sectional study"],"prefix":"10.1186","volume":"24","author":[{"given":"Bo","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peili","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyu","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhi","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengrong","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingguo","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianrong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongqing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongwen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoxie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanjuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoquan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaozhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinyin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanzhang","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,22]]},"reference":[{"issue":"5","key":"9005_CR1","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1111\/j.1469-0691.2012.03823.x","volume":"18","author":"M Akova","year":"2012","unstructured":"Akova M, Daikos GL, Tzouvelekis L, Carmeli Y. Interventional strategies and current clinical experience with carbapenemase-producing gram-negative bacteria. Clin Microbiol Infect. 2012;18(5):439\u201348. https:\/\/doi.org\/10.1111\/j.1469-0691.2012.03823.x.","journal-title":"Clin Microbiol Infect"},{"issue":"2","key":"9005_CR2","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S1473-3099(15)00424-7","volume":"16","author":"YY Liu","year":"2016","unstructured":"Liu YY, Wang Y, Walsh TR, et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis. 2016;16(2):161\u20138. https:\/\/doi.org\/10.1016\/S1473-3099(15)00424-7.","journal-title":"Lancet Infect Dis"},{"key":"9005_CR3","doi-asserted-by":"publisher","first-page":"80","DOI":"10.3389\/fmicb.2019.00080","volume":"10","author":"CC Sheu","year":"2019","unstructured":"Sheu CC, Chang YT, Lin SY, Chen YH, Hsueh PR. Infections caused by Carbapenem-Resistant Enterobacterales: an update on therapeutic options. Front Microbiol. 2019;10:80.\u00a0 https:\/\/doi.org\/10.3389\/fmicb.2019.00080.","journal-title":"Front Microbiol"},{"issue":"12","key":"9005_CR4","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1007\/s11908-016-0548-3","volume":"18","author":"DR Bowers","year":"2016","unstructured":"Bowers DR, Huang V. Emerging issues and treatment strategies in carbapenem-resistant enterobacterales (CRE). Curr Infect Dis Rep. 2016;18(12):48. https:\/\/doi.org\/10.1007\/s11908-016-0548-3.","journal-title":"Curr Infect Dis Rep"},{"issue":"1","key":"9005_CR5","doi-asserted-by":"publisher","first-page":"115557","DOI":"10.1016\/j.diagmicrobio.2021.115557","volume":"102","author":"HS Sader","year":"2022","unstructured":"Sader HS, Mendes RE, Streit JM, Carvalhaes CG, Castanheira M. Antimicrobial susceptibility of gram-negative bacteria from intensive care unit and non-intensive care unit patients from United States hospitals (2018\u20132020). Diagn Microbiol Infect Dis. 2022;102(1):115557.\u00a0https:\/\/doi.org\/10.1016\/j.diagmicrobio.2021.115557.","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"1","key":"9005_CR6","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1186\/s13756-020-00816-4","volume":"9","author":"L Yan","year":"2020","unstructured":"Yan L, Sun J, Xu X, Huang S. Epidemiology and risk factors of rectal colonization of carbapenemase-producing enterobacterales among high-risk patients from ICU and HSCT wards in a university hospital. Antimicrob Resist Infect Control. 2020;9(1):155. https:\/\/doi.org\/10.1186\/s13756-020-00816-4.","journal-title":"Antimicrob Resist Infect Control"},{"issue":"18","key":"9005_CR7","doi-asserted-by":"publisher","first-page":"e140","DOI":"10.3346\/jkms.2019.34.e140","volume":"34","author":"JS Kang","year":"2019","unstructured":"Kang JS, Yi J, Ko MK, Lee SO, Lee JE, Kim KH. Prevalence and risk factors of carbapenem-resistant enterobacterales acquisition in an emergency intensive care unit in a tertiary hospital in Korea: a case-control study. J Korean Med Sci. 2019;34(18):e140. https:\/\/doi.org\/10.3346\/jkms.2019.34.e140.","journal-title":"J Korean Med Sci"},{"key":"9005_CR8","doi-asserted-by":"publisher","first-page":"815","DOI":"10.2147\/IDR.S286401","volume":"14","author":"Y Wang","year":"2021","unstructured":"Wang Y, Lin Q, Chen Z, et al. Construction of a risk prediction model for subsequent bloodstream infection in intestinal carriers of carbapenem-resistant enterobacterales: a retrospective study in Hematology Department and Intensive Care Unit. Infect Drug Resist. 2021;14:815\u201324. https:\/\/doi.org\/10.2147\/IDR.S286401.","journal-title":"Infect Drug Resist"},{"issue":"1","key":"9005_CR9","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s13756-021-00994-9","volume":"10","author":"K Garpvall","year":"2021","unstructured":"Garpvall K, Duong V, Linnros S, et al. Admission screening and cohort care decrease carbapenem resistant enterobacterales in Vietnamese pediatric ICU\u2019s. Antimicrob Resist Infect Control. 2021;10(1):128. https:\/\/doi.org\/10.1186\/s13756-021-00994-9.","journal-title":"Antimicrob Resist Infect Control"},{"key":"9005_CR10","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.jgar.2022.04.005","volume":"30","author":"Y Gao","year":"2022","unstructured":"Gao Y, Chen M, Cai M, et al. An analysis of risk factors for carbapenem-resistant enterobacterales infection. J Glob Antimicrob Resist. 2022;30:191\u20138. https:\/\/doi.org\/10.1016\/j.jgar.2022.04.005.","journal-title":"J Glob Antimicrob Resist"},{"key":"9005_CR11","doi-asserted-by":"publisher","first-page":"3512582","DOI":"10.1155\/2022\/3512582","volume":"2022","author":"G Liu","year":"2022","unstructured":"Liu G, Qin M. Analysis of the distribution and antibiotic resistance of pathogens causing infections in hospitals from 2017 to 2019. Evid Based Complement Alternat Med. 2022;2022:3512582. https:\/\/doi.org\/10.1155\/2022\/3512582.","journal-title":"Evid Based Complement Alternat Med"},{"issue":"6","key":"9005_CR12","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1089\/mdr.2021.0326","volume":"28","author":"J Chen","year":"2022","unstructured":"Chen J, Xiang Q, Wu JY, et al. Different effects of antibiotics on Klebsiella pneumoniae and Escherichia coli resistance induced by antibiotics: a retrospective study from China. Microb Drug Resist. 2022;28(6):660\u20139. https:\/\/doi.org\/10.1089\/mdr.2021.0326.","journal-title":"Microb Drug Resist"},{"key":"9005_CR13","doi-asserted-by":"publisher","first-page":"894341","DOI":"10.3389\/fmicb.2022.894341","volume":"13","author":"B Guo","year":"2022","unstructured":"Guo B, Guo Z, Zhang H, et al. Prevalence and risk factors of carbapenem-resistant Enterobacterales positivity by active screening in intensive care units in the Henan Province of China: a multi-center cross-sectional study. Front Microbiol. 2022;13:894341.\u00a0https:\/\/doi.org\/10.3389\/fmicb.2022.894341.","journal-title":"Front Microbiol"},{"issue":"3","key":"9005_CR14","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1080\/14787210.2020.1822736","volume":"19","author":"F Aleidan","year":"2021","unstructured":"Aleidan F, Alkhelaifi H, Alsenaid A, et al. Incidence and risk factors for carbapenem-resistant enterobacterales infection in intensive care units: a matched case\u2013control study. Expert Rev Anti Infect Ther. 2021;19(3):393\u20138. https:\/\/doi.org\/10.1080\/14787210.2020.1822736.","journal-title":"Expert Rev Anti Infect Ther"},{"key":"9005_CR15","doi-asserted-by":"publisher","unstructured":"Tamma PD, Kazmi A, Bergman Y, et al. The likelihood of developing a carbapenem-resistant enterobacterales infection during a hospital stay. Antimicrob Agents Chemother. 2019;63(8). https:\/\/doi.org\/10.1128\/AAC.00757-19.","DOI":"10.1128\/AAC.00757-19"},{"issue":"9","key":"9005_CR16","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1017\/ice.2018.150","volume":"39","author":"T Shimasaki","year":"2018","unstructured":"Shimasaki T, Segreti J, Tomich A, Kim J, Hayden MK, Lin MY. Active screening and interfacility communication of carbapenem-resistant Enterobacterales (CRE) in a tertiary-care hospital. Infect Control Hosp Epidemiol. 2018;39(9):1058\u201362. https:\/\/doi.org\/10.1017\/ice.2018.150.","journal-title":"Infect Control Hosp Epidemiol"},{"key":"9005_CR17","doi-asserted-by":"publisher","unstructured":"Sakai Y, Gotoh K, Nakano R, et al. Infection control for a carbapenem-resistant enterobacterales outbreak in an advanced emergency medical services center. Antibiot (Basel). 2021;10(12):1537. https:\/\/doi.org\/10.3390\/antibiotics10121537.","DOI":"10.3390\/antibiotics10121537"},{"issue":"11","key":"9005_CR18","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1017\/ice.2018.235","volume":"39","author":"G Regev-Yochay","year":"2018","unstructured":"Regev-Yochay G, Smollan G, Tal I, et al. Sink traps as the source of transmission of OXA-48-producing Serratia marcescens in an intensive care unit. Infect Control Hosp Epidemiol. 2018;39(11):1307\u201315. https:\/\/doi.org\/10.1017\/ice.2018.235.","journal-title":"Infect Control Hosp Epidemiol"},{"issue":"6","key":"9005_CR19","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.3201\/eid2606.190965","volume":"26","author":"MC Salom\u00e3o","year":"2020","unstructured":"Salom\u00e3o MC, Freire MP, Boszczowski I, Raymundo SF, Guedes AR, Levin AS. Increased risk for carbapenem-resistant enterobacterales colonization in intensive care units after hospitalization in Emergency Department. Emerg Infect Dis. 2020;26(6):1156\u201363. https:\/\/doi.org\/10.3201\/eid2606.190965.","journal-title":"Emerg Infect Dis"},{"issue":"2","key":"9005_CR20","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.jinf.2019.05.013","volume":"79","author":"DM Tran","year":"2019","unstructured":"Tran DM, Larsson M, Olson L, et al. High prevalence of colonization with carbapenem-resistant Enterobacterales among patients admitted to Vietnamese hospitals: risk factors and burden of disease. J Infect. 2019;79(2):115\u201322. https:\/\/doi.org\/10.1016\/j.jinf.2019.05.013.","journal-title":"J Infect"},{"key":"9005_CR21","doi-asserted-by":"publisher","first-page":"2510875","DOI":"10.1155\/2019\/2510875","volume":"2019","author":"DC Zaha","year":"2019","unstructured":"Zaha DC, Kiss R, Heged\u0171s C, et al. Recent advances in Investigation, prevention, and management of healthcare-associated infections (HAIs): resistant multidrug strain colonization and its risk factors in an intensive care unit of a University Hospital. Biomed Res Int. 2019;2019:2510875. https:\/\/doi.org\/10.1155\/2019\/2510875.","journal-title":"Biomed Res Int"},{"key":"9005_CR22","doi-asserted-by":"publisher","first-page":"314","DOI":"10.3389\/fcimb.2020.00314","volume":"10","author":"R Han","year":"2020","unstructured":"Han R, Shi Q, Wu S, et al. Dissemination of carbapenemases (KPC, NDM, OXA-48, IMP, and VIM) among carbapenem-resistant enterobacterales isolated from adult and children patients in China. Front Cell Infect Microbiol. 2020;10:314. https:\/\/doi.org\/10.3389\/fcimb.2020.00314.","journal-title":"Front Cell Infect Microbiol"},{"key":"9005_CR23","doi-asserted-by":"publisher","first-page":"716324","DOI":"10.3389\/fphar.2021.716324","volume":"12","author":"Q Lin","year":"2021","unstructured":"Lin Q, Wu M, Yu H, et al. Clinical and microbiological characterization of carbapenem-resistant enterobacteriales: a prospective cohort study. Front Pharmacol. 2021;12:716324.","journal-title":"Front Pharmacol"},{"issue":"1","key":"9005_CR24","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1186\/s12879-021-06315-0","volume":"21","author":"Q Lin","year":"2021","unstructured":"Lin Q, Wang Y, Yu J, et al. Bacterial characteristics of carbapenem-resistant Enterobacterales (CRE) colonized strains and their correlation with subsequent infection. BMC Infect Dis. 2021;21(1):638. https:\/\/doi.org\/10.1186\/s12879-021-06315-0.","journal-title":"BMC Infect Dis"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-024-09005-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12879-024-09005-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-024-09005-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T16:02:33Z","timestamp":1705939353000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-024-09005-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,22]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["9005"],"URL":"https:\/\/doi.org\/10.1186\/s12879-024-09005-9","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,22]]},"assertion":[{"value":"27 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the medical ethics committee of Henan People\u2019s Hospital (ethics number: (2020) Ethical Review No. (143)). All patients signed an informed consent form. All methods were carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"116"}}