{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:40:04Z","timestamp":1791294004980,"version":"4.1.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Tianjin Applied Basic Research Project","award":["22JCQNJC01590"],"award-info":[{"award-number":["22JCQNJC01590"]}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-047A"],"award-info":[{"award-number":["TJYXZDXK-047A"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p><jats:italic>Fusobacterium nucleatum<\/jats:italic> (<jats:italic>F. nucleatum<\/jats:italic>) belongs to the genus Fusobacterium, which is a gram-negative obligate anaerobic bacterium. Bacteremia associated with <jats:italic>F. nucleatum<\/jats:italic> is a serious complication, which is not common in clinic, especially when it is combined with other intracranial pathogenic microorganism infection. We reported for the first time a case of <jats:italic>F. nucleatum<\/jats:italic> bacteremia combined with intracranial <jats:italic>Porphyromonas gingivalis<\/jats:italic> (<jats:italic>P. gingivalis<\/jats:italic>) and <jats:italic>herpes simplex virus type 1<\/jats:italic>(<jats:italic>HSV-1<\/jats:italic>) infection.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 60-year-old woman was admitted to our hospital with a headache for a week that worsened for 2 days. Combined with history, physical signs and examination, it was characterized as ischemic cerebrovascular disease (ICVD). <jats:italic>F. nucleatum<\/jats:italic> was detected in blood by matrix-assisted laser desorption\/ionization time-offight mass spectrometry (MALDI-TOF-MS). Meanwhile, <jats:italic>P. gingivalis<\/jats:italic> and <jats:italic>HSV-1<\/jats:italic> in cerebrospinal fluid (CSF) were identified by metagenome next generation sequencing (mNGS). After a quick diagnosis and a combination of antibiotics and antiviral treatment, the patient recovered and was discharged.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>To our knowledge, this is the first report of intracranial <jats:italic>P. gingivalis<\/jats:italic> and <jats:italic>HSV-1<\/jats:italic> infection combined with <jats:italic>F. nucleatum<\/jats:italic> bacteremia.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-024-09078-6","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T10:02:39Z","timestamp":1708423359000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fusobacterium nucleatum bacteremia complicated with intracranial Porphyromonas gingivalis and HSV-1 infection: a case report and literature review"],"prefix":"10.1186","volume":"24","author":[{"given":"Sumei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqiong","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuye","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"issue":"8","key":"9078_CR1","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.cmi.2018.11.030","volume":"25","author":"R Dyrhovden","year":"2019","unstructured":"Dyrhovden R, Nygaard RM, Patel R, Ulvestad E, Kommedal \u00d8. 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