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However, the concurrent impact of coinfection on gastric pathology has yet to be studied in depth. The effect of coinfection generally either adds a synergetic or antagonistic impact; we aimed in the current work to assess the impact of <jats:italic>T. gondii<\/jats:italic> coinfection on the progression of <jats:italic>H. pylori-<\/jats:italic>associated gastric pathology and reporting <jats:italic>H. pylori<\/jats:italic> virulent strains. The study was conducted on 82 patients complaining of persistent gastrointestinal symptoms with failed treatment response and prone to endoscopy. They were subjected to stool examination to detect <jats:italic>H. pylori<\/jats:italic> antigen, serological screening for latent toxoplasmosis, endoscopy, histopathological examination, and molecular detection of <jats:italic>H. pylori<\/jats:italic> virulence strains in gastric biopsies. Out of the 82 patients, 62 patients were positive for <jats:italic>H. pylori<\/jats:italic> antigen in stool and 55 patients confirmed positivity by histopathology; out of them, 37 patients had isolated <jats:italic>Vac As1<\/jats:italic> variants, 11 patients had combined <jats:italic>Vac As1<\/jats:italic> and <jats:italic>Cag A<\/jats:italic> variants, and 7 patients had combined <jats:italic>Vac As1<\/jats:italic>, <jats:italic>Cag A<\/jats:italic> and <jats:italic>VacAs2<\/jats:italic> variants. Patients with the combined two or three variances showed significantly deteriorated histopathological features than patients with a single <jats:italic>Vac As1<\/jats:italic> variant (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Latent toxoplasmosis was positive among 35\/82 patients. Combined <jats:italic>H. pylori<\/jats:italic> and <jats:italic>Toxoplasma gondii<\/jats:italic> infection had significantly marked inflammation than patients with isolated infection (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Conclusion: Screening for toxoplasmosis among <jats:italic>H. pylori<\/jats:italic>-infected patients is recommended as it is considered a potential risk factor for gastric inflammation severity. <jats:italic>H. pylori<\/jats:italic> gastric inflammation may be heightened by <jats:italic>Toxoplasma<\/jats:italic> coinfection.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-024-09270-8","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T08:02:09Z","timestamp":1713254529000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of concurrent infection of Helicobacter pylori with Toxoplasma gondii infection on gastric pathology"],"prefix":"10.1186","volume":"24","author":[{"given":"Marwa A.","family":"Gouda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8183-7868","authenticated-orcid":false,"given":"Sara A.","family":"Saied","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Edrees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha Galal","family":"Mostafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf","family":"Elfert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya Abdallah","family":"seleem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa","family":"Shams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameh","family":"Afify","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"9270_CR1","doi-asserted-by":"crossref","unstructured":"Akoolo L, Rocha SC, Parveen N. 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