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GATA binding protein 2 (\n                      <jats:italic>GATA2<\/jats:italic>\n                      ) is a transcription factor and key component in haematopoiesis and stem cell biology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>\n                      Three patients with HLH, one with\n                      <jats:italic>Mycobacterium avium<\/jats:italic>\n                      infection, one with Epstein\u2013Barr virus (EBV) infection, and one with\n                      <jats:italic>Mycobacterium kansasii<\/jats:italic>\n                      infection, were all subsequently found to have a defect in the\n                      <jats:italic>GATA2<\/jats:italic>\n                      gene through genetic testing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>GATA2<\/jats:italic>\n                      deficiency syndrome should be considered in patients with myelodysplastic syndrome,\n                      <jats:italic>nontuberculous mycobacterium<\/jats:italic>\n                      infection and HLH. In addition, the\n                      <jats:italic>GATA2<\/jats:italic>\n                      gene variant may be a genetic defect that could be the cause of the primary HLH. However, further studies are needed to confirm the role of\n                      <jats:italic>GATA2<\/jats:italic>\n                      pathogenic variants in the pathogenesis of HLH.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12879-024-09356-3","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T08:01:32Z","timestamp":1715328092000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Haemophagocytic lymphohistiocytosis caused by GATA2 deficiency: a report on three patients"],"prefix":"10.1186","volume":"24","author":[{"given":"Lin","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingshi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deli","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahong","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,10]]},"reference":[{"issue":"16","key":"9356_CR1","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1182\/blood.2019000936","volume":"135","author":"SW Canna","year":"2020","unstructured":"Canna SW, Marsh RA. 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