{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:31:01Z","timestamp":1793039461925,"version":"4.5.0"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100018623","name":"Quanzhou City Science and Technology Program","doi-asserted-by":"publisher","award":["2023N046S"],"award-info":[{"award-number":["2023N046S"]}],"id":[{"id":"10.13039\/501100018623","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p><jats:italic>Phytobacter diazotrophicus<\/jats:italic> (<jats:italic>P<\/jats:italic>. <jats:italic>diazotrophicus<\/jats:italic>) is an opportunistic pathogen that causes nosocomial outbreaks and sepsis. However, there are no reports of <jats:italic>P. diazotrophicus<\/jats:italic> isolated from human blood in China.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 27-day-old female infant was admitted to our hospital with fever and high bilirubin levels. The clinical features included jaundice, abnormal coagulation, cholestasis, fever, convulsions, weak muscle tension, sucking weakness, ascites, abnormal tyrosine metabolism, cerebral oedema, abnormal liver function, clavicle fracture, and haemolytic anaemia. The strain isolated from the patient\u2019s blood was identified as <jats:italic>P. diazotrophicus<\/jats:italic> by whole-genome sequencing (WGS). Galactosemia type 1 (GALAC1) was diagnosed using whole-exome sequencing (WES). Based on drug sensitivity results, 10 days of anti-infective treatment with meropenem combined with lactose-free milk powder improved symptoms.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p><jats:italic>P. diazotrophicus<\/jats:italic> was successfully identified in a patient with neonatal sepsis combined with galactosemia. Galactosemia may be an important factor in neonatal sepsis. This case further expands our understanding of the clinical characteristics of GALAC1.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-024-09458-y","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T06:02:14Z","timestamp":1718776934000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Sepsis caused by Phytobacter diazotrophicus complicated with galactosemia type 1 in China: a case report"],"prefix":"10.1186","volume":"24","author":[{"given":"Jiansheng","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoxiong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"key":"9458_CR1","doi-asserted-by":"publisher","first-page":"e0014723","DOI":"10.1128\/msphere.00147-23","volume":"8","author":"H Kubota","year":"2023","unstructured":"Kubota H, Nakayama T, Ariyoshi T, Uehara S, Uchitani Y, Tsuchida S, Nishiyama H, Morioka I, Koshinaga T, Kusabuka A, Nakatsubo N, Yamagishi T, Tabuchi Y, Okuno R, Kobayashi K, Mitobe M, Yokoyama K, Shinkai T, Suzuki J, Sadamasu K. Emergence of Phytobacter diazotrophicus carrying an IncA\/C2 plasmid harboring blaNDM-1 in Tokyo. Japan mSphere. 2023;8:e0014723. https:\/\/doi.org\/10.1128\/msphere.00147-23.","journal-title":"Japan mSphere"},{"key":"9458_CR2","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s00203-007-0333-7","volume":"189","author":"GX Zhang","year":"2008","unstructured":"Zhang GX, Peng GX, Wang ET, Yan H, Yuan QH, Zhang W, Lou X, Wu H, Tan ZY. Diverse endophytic nitrogen-fixing bacteria isolated from wild rice Oryza rufipogon and description of Phytobacter diazotrophicus gen. nov. sp. nov. Arch Microbiol. 2008;189:431\u20139. https:\/\/doi.org\/10.1007\/s00203-007-0333-7.","journal-title":"Arch Microbiol"},{"key":"9458_CR3","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1099\/ijsem.0.002477","volume":"68","author":"M Pillonetto","year":"2018","unstructured":"Pillonetto M, Arend LN, Faoro H, D\u2019Espindula HRS, Blom J, Smits THM, Mira MT, Rezzonico F. Emended description of the genus Phytobacter, its type species Phytobacter diazotrophicus (Zhang 2008) and description of phytobacter ursingii sp. nov. Int J Syst Evol Microbiol. 2018;68:176\u201384. https:\/\/doi.org\/10.1099\/ijsem.0.002477.","journal-title":"Int J Syst Evol Microbiol"},{"key":"9458_CR4","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1186\/s12879-018-3287-2","volume":"18","author":"M Pillonetto","year":"2018","unstructured":"Pillonetto M, Arend L, Gomes SMT, Oliveira MAA, Timm LN, Martins AF, Barth AL, Mazzetti A, Hersemann L, Smits THM, Mira MT, Rezzonico F. Molecular investigation of isolates from a multistate polymicrobial outbreak associated with contaminated total parenteral nutrition in Brazil. BMC Infect Dis. 2018;18:397. https:\/\/doi.org\/10.1186\/s12879-018-3287-2.","journal-title":"BMC Infect Dis"},{"key":"9458_CR5","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1007\/s10096-022-04413-8","volume":"41","author":"THM Smits","year":"2022","unstructured":"Smits THM, Arend LNVS, Cardew S, T\u00e5ng-Hallb\u00e4ck E, Mira MT, Moore ERB, Sampaio JLM, Rezzonico F, Pillonetto M. Resolving taxonomic confusion: establishing the genus phytobacter on the list of clinically relevant Enterobacteriaceae. Eur J Clin Microbiol Infect Dis. 2022;41:547\u201358. https:\/\/doi.org\/10.1007\/s10096-022-04413-8.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"9458_CR6","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.jhin.2005.01.004","volume":"61","author":"H Habsah","year":"2005","unstructured":"Habsah H, Zeehaida M, Van Rostenberghe H, Noraida R, Wan Pauzi WI, Fatimah I, Rosliza AR, Nik Sharimah NY, Maimunah H. An outbreak of Pantoea spp. in a neonatal intensive care unit secondary to contaminated parenteral nutrition. J Hosp Infect. 2005;61:213\u20138. https:\/\/doi.org\/10.1016\/j.jhin.2005.01.004.","journal-title":"J Hosp Infect"},{"key":"9458_CR7","doi-asserted-by":"publisher","first-page":"968","DOI":"10.3390\/biom12070968","volume":"12","author":"M Succoio","year":"2022","unstructured":"Succoio M, Sacchettini R, Rossi A, Parenti G, Ruoppolo M, Galactosemia. Biochemistry, Molecular Genetics, Newborn Screening, and treatment. Biomolecules. 2022;12:968. https:\/\/doi.org\/10.3390\/biom12070968.","journal-title":"Biomolecules"},{"key":"9458_CR8","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1056\/NEJM197710132971510","volume":"297","author":"HL Levy","year":"1977","unstructured":"Levy HL, Sepe SJ, Shih VE, Vawter GF, Klein JO. Sepsis due to Escherichia coli in neonates with galactosemia. N Engl J Med. 1977;297:823\u20135. https:\/\/doi.org\/10.1056\/NEJM197710132971510.","journal-title":"N Engl J Med"},{"key":"9458_CR9","doi-asserted-by":"publisher","first-page":"e02011","DOI":"10.1128\/mBio.02011-17","volume":"9","author":"RA Weingarten","year":"2018","unstructured":"Weingarten RA, Johnson RC, Conlan S, Ramsberg AM, Dekker JP, Lau AF, Khil P, Odom RT, Deming C, Park M, Thomas PJ, Comparative Sequencing Program NISC, Henderson DK, Palmore TN, Segre JA, Frank KM. 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Meanwhile, written informed consent to participate in this study was provided by the participants\u2019 legal guardian.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the participants\u2019 legal guardian for the publication of all presentations of this case report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"599"}}