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Understanding the willingness of the community to receive the COVID-19 vaccine will help in the development and implementation of effective COVID-19 vaccination promotion programs. Therefore, we aimed to assess the level of COVID-19 vaccine acceptance and associated factors among residents of Dire Dawa Administration, Eastern Ethiopia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A community-based cross-sectional study was conducted among 840 residents in Dire Dawa Administration from May 18th to June 18th, 2021. Multistage cluster sampling followed by systematic random sampling was used to select respondents. A pretested interviewer-administered structured questionnaire was used to collect the data from respondents. Bivariable and multivariable logistic regression were used to identify predictors of COVID-19 vaccine acceptance. The odds ratio (OR), along with a 95% confidence interval (CI), was used to estimate the strength of the association.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Out of 840 respondents recruited, the proportion of COVID-19 vaccine acceptance was found to be 54.4% (457\/840); (95% CI: 51.0%, 57.7%) Being male [AOR\u2009=\u20091.85, 95% CI: (1.35, 2.54), <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001], not having a current habit of substance use [AOR\u2009=\u20092.38, 95% CI: (1.73, 3.26), <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001], having a monthly income of less than 51.31 USD [AOR\u2009=\u20090.19, 95% CI: (0.04, 0.88), <jats:italic>P<\/jats:italic>\u2009=\u20090.001]; and not having a prior history of vaccination experience [AOR\u2009=\u20090.40, 95% CI: (0.29, 0.54), <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001] were significantly associated with COVID-19 vaccine acceptance.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This study reveals that the proportion of COVID-19 vaccine acceptance among residents of Dire Dawa Administration, Eastern Ethiopia, was 54.4%. Factors like being male and not having a current habit of substance use were positively associated, whereas having a monthly income of less than 51.31 USD and not having a prior history of vaccination experience were negatively associated with COVID-19 vaccine acceptance. Health information dissemination and economic empowerment are crucial to improving COVID-19 vaccine acceptance among the community. This study provides valuable data for policymakers to plan early vaccination programs and tackle the challenges identified in the study.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-024-09556-x","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T07:02:05Z","timestamp":1720681325000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Coronavirus disease 2019 vaccination acceptance and associated factors among residents of Dire Dawa Administration, Eastern Ethiopia: a community-based cross-sectional study"],"prefix":"10.1186","volume":"24","author":[{"given":"Tafese Dejene","family":"Jidha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endayen","family":"Deginet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bereket","family":"Tefera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demisew","family":"Amenu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girma","family":"Beressa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mickiale","family":"Hailu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,11]]},"reference":[{"issue":"20","key":"9556_CR1","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1001\/jama.2020.6775","volume":"323","author":"S Richardson","year":"2020","unstructured":"Richardson S, Hirsch JS, Narasimhan M, et al. 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A permission letter was obtained from the Dire Dawa Administration. A permission letter for data collection was also obtained from the respective kebele administrators. The method was conducted in accordance with the relevant tenets of the Helsinki Declaration. Written informed consent was obtained from the study participants involved in the study, and all participants regardless of their literacy were directly asked to consent to participate in the study, having informed all the benefits, risks and rights of participants. Though the study objectives was to assess the perception of participants for Covid-19 vaccination and no further questions were asked which requires participants literacy, we have considered their age as a criterion for autonomy to decide to participate in the study. Participants were informed that they had the right to withdraw from the study at any point during data collection. The privacy of participants was maintained by interviewing in isolated areas. Confidentiality of the data was assured by the anonymity of questionnaires, and they were kept in a locked cabinet.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"689"}}