{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:33:39Z","timestamp":1790012019936,"version":"4.0.1"},"reference-count":80,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"DOI":"10.1186\/s12879-024-10272-9","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T09:50:02Z","timestamp":1734515402000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Designing and comparative analysis of anti-oxidant and heat shock proteins based multi-epitopic filarial vaccines"],"prefix":"10.1186","volume":"24","author":[{"given":"Sunil","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayushi","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vipin","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tripti","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anchal","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"issue":"10","key":"10272_CR1","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1056\/NEJMra064142","volume":"357","author":"PJ Hotez","year":"2007","unstructured":"Hotez PJ, Molyneux DH, Fenwick A, Kumaresan J, Sachs SE, Sachs JD, Savioli L. Control of neglected tropical diseases. N Engl J Med. 2007;357(10):1018\u201327.","journal-title":"N Engl J Med"},{"issue":"3","key":"10272_CR2","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1089\/lrb.2013.0021","volume":"11","author":"TB Nutman","year":"2013","unstructured":"Nutman TB. Insights into the pathogenesis of disease in human lymphatic filariasis. Lymphatic Res Biology. 2013;11(3):144\u20138.","journal-title":"Lymphatic Res Biology"},{"issue":"9","key":"10272_CR3","doi-asserted-by":"publisher","first-page":"e1186","DOI":"10.1016\/S2214-109X(20)30286-2","volume":"8","author":"EA Cromwell","year":"2020","unstructured":"Cromwell EA, Schmidt CA, Kwong KT, Pigott DM, Mupfasoni D, Biswas G, Shirude S, Hill E, Donkers KM, Abdoli A. The global distribution of lymphatic filariasis, 2000\u201318: a geospatial analysis. Lancet Global Health. 2020;8(9):e1186\u201394.","journal-title":"Lancet Global Health"},{"issue":"7","key":"10272_CR4","doi-asserted-by":"publisher","first-page":"e0270635","DOI":"10.1371\/journal.pone.0270635","volume":"17","author":"V Kumar","year":"2022","unstructured":"Kumar V, Mishra A, Yadav AK, Rathaur S, Singh A. Lymphatic filarial serum proteome profiling for identification and characterization of diagnostic biomarkers. PLoS ONE. 2022;17(7):e0270635.","journal-title":"PLoS ONE"},{"key":"10272_CR5","doi-asserted-by":"crossref","unstructured":"Das PK, Shenoy RK. Helminthic Diseases: Filariasis. 2017.","DOI":"10.1016\/B978-0-12-803678-5.00203-4"},{"issue":"1","key":"10272_CR6","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s40249-016-0183-0","volume":"5","author":"A Kwarteng","year":"2016","unstructured":"Kwarteng A, Ahuno ST, Akoto FO. Killing filarial nematode parasites: role of treatment options and host immune response. Infect Dis Poverty. 2016;5(1):86.","journal-title":"Infect Dis Poverty"},{"key":"10272_CR7","doi-asserted-by":"publisher","first-page":"105237","DOI":"10.1016\/j.meegid.2022.105237","volume":"98","author":"S Gorai","year":"2022","unstructured":"Gorai S, Das NC, Gupta PSS, Panda SK, Rana MK, Mukherjee S. Designing efficient multi-epitope peptide-based vaccine by targeting the antioxidant thioredoxin of bancroftian filarial parasite. Infect Genet Evol. 2022;98:105237.","journal-title":"Infect Genet Evol"},{"issue":"10","key":"10272_CR8","doi-asserted-by":"publisher","first-page":"e0008644","DOI":"10.1371\/journal.pntd.0008644","volume":"14","author":"BS Collyer","year":"2020","unstructured":"Collyer BS, Irvine MA, Hollingsworth TD, Bradley M, Anderson RM. Defining a prevalence level to describe the elimination of lymphatic filariasis (LF) transmission and designing monitoring & evaluating (M&E) programmes post the cessation of mass drug administration (MDA). PLoS Negl Trop Dis. 2020;14(10):e0008644.","journal-title":"PLoS Negl Trop Dis"},{"key":"10272_CR9","doi-asserted-by":"publisher","first-page":"998353","DOI":"10.3389\/fitd.2022.998353","volume":"3","author":"V Melendez","year":"2022","unstructured":"Melendez V, Turner C, Khatri V, Davis J, Chauhan N, Nagalati Sudhakar DS, Cabullos R, Carter D, Gray SA, Kalyanasundaram R. Pre-clinical development of a vaccine for human lymphatic filariasis. Front Trop Dis. 2022;3:998353.","journal-title":"Front Trop Dis"},{"issue":"3","key":"10272_CR10","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1128\/CMR.00002-13","volume":"26","author":"CP Morris","year":"2013","unstructured":"Morris CP, Evans H, Larsen SE, Mitre E. A comprehensive, model-based review of vaccine and repeat infection trials for filariasis. Clin Microbiol Rev. 2013;26(3):381\u2013421.","journal-title":"Clin Microbiol Rev"},{"key":"10272_CR11","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.provac.2010.11.003","volume":"3","author":"A Samykutty","year":"2010","unstructured":"Samykutty A, Dakshinamoorthy G, Kalyanasundaram R. Multivalent vaccine for lymphatic filariasis. Procedia Vaccinol. 2010;3:12\u20138.","journal-title":"Procedia Vaccinol"},{"issue":"36","key":"10272_CR12","doi-asserted-by":"publisher","first-page":"5013","DOI":"10.1016\/j.vaccine.2009.05.009","volume":"27","author":"W-Y Zhou","year":"2009","unstructured":"Zhou W-Y, Shi Y, Wu C, Zhang W-J, Mao X-H, Guo G, Li H-X, Zou Q-M. Therapeutic efficacy of a multi-epitope vaccine against Helicobacter pylori infection in BALB\/c mice model. Vaccine. 2009;27(36):5013\u20139.","journal-title":"Vaccine"},{"issue":"2","key":"10272_CR13","doi-asserted-by":"publisher","first-page":"140","DOI":"10.3390\/pharmaceutics13020140","volume":"13","author":"A Bouazzaoui","year":"2021","unstructured":"Bouazzaoui A, Abdellatif AA, Al-Allaf FA, Bogari NM, Al-Dehlawi S, Qari SH. Strategies for vaccination: conventional vaccine approaches versus new-generation strategies in combination with adjuvants. Pharmaceutics. 2021;13(2):140.","journal-title":"Pharmaceutics"},{"issue":"1","key":"10272_CR14","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1038\/s41598-020-80899-6","volume":"11","author":"S Bibi","year":"2021","unstructured":"Bibi S, Ullah I, Zhu B, Adnan M, Liaqat R, Kong W-B, Niu S. In silico analysis of epitope-based vaccine candidate against tuberculosis using reverse vaccinology. Sci Rep. 2021;11(1):1249.","journal-title":"Sci Rep"},{"key":"10272_CR15","doi-asserted-by":"publisher","first-page":"621706","DOI":"10.3389\/fimmu.2021.621706","volume":"12","author":"RC Sanches","year":"2021","unstructured":"Sanches RC, Tiwari S, Ferreira LC, Oliveira FM, Lopes MD, Passos MJ, Maia EH, Taranto AG, Kato R, Azevedo VA. Immunoinformatics design of multi-epitope peptide-based vaccine against Schistosoma mansoni using transmembrane proteins as a target. Front Immunol. 2021;12:621706.","journal-title":"Front Immunol"},{"issue":"1","key":"10272_CR16","doi-asserted-by":"publisher","first-page":"4409","DOI":"10.1038\/s41598-019-40833-x","volume":"9","author":"RA Shey","year":"2019","unstructured":"Shey RA, Ghogomu SM, Esoh KK, Nebangwa ND, Shintouo CM, Nongley NF, Asa BF, Ngale FN, Vanhamme L, Souopgui J. In-silico design of a multi-epitope vaccine candidate against onchocerciasis and related filarial diseases. Sci Rep. 2019;9(1):4409.","journal-title":"Sci Rep"},{"key":"10272_CR17","doi-asserted-by":"publisher","first-page":"S19","DOI":"10.1016\/j.actatropica.2010.04.010","volume":"120","author":"GJ Weil","year":"2011","unstructured":"Weil GJ, Curtis KC, Fischer PU, Won KY, Lammie PJ, Joseph H, Melrose WD, Brattig NW. A multicenter evaluation of a new antibody test kit for lymphatic filariasis employing recombinant Brugia malayi antigen Bm-14. Acta Trop. 2011;120:S19\u201322.","journal-title":"Acta Trop"},{"issue":"1","key":"10272_CR18","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/s42003-019-0392-8","volume":"2","author":"S Mukherjee","year":"2019","unstructured":"Mukherjee S, Karnam A, Das M, Babu SPS, Bayry J. Wuchereria bancrofti filaria activates human dendritic cells and polarizes T helper 1 and regulatory T cells via toll-like receptor 4. Commun Biology. 2019;2(1):169.","journal-title":"Commun Biology"},{"key":"10272_CR19","doi-asserted-by":"publisher","first-page":"112120","DOI":"10.1016\/j.intimp.2024.112120","volume":"133","author":"NC Das","year":"2024","unstructured":"Das NC, Gorai S, Gupta PSS, Panda SK, Rana MK, Mukherjee S. Immune targeting of filarial glutaredoxin through a multi-epitope peptide-based vaccine: a reverse vaccinology approach. Int Immunopharmacol. 2024;133:112120.","journal-title":"Int Immunopharmacol"},{"key":"10272_CR20","doi-asserted-by":"crossref","unstructured":"Mukherjee S, Joardar N, Sinha Babu SP. Redox regulatory circuits as targets for therapeutic intervention of bancroftian filariasis: biochemical, molecular, and pharmacological perspectives. Oxidative Stress Microb Dis. 2019;185\u2013208.","DOI":"10.1007\/978-981-13-8763-0_10"},{"issue":"32","key":"10272_CR21","doi-asserted-by":"publisher","first-page":"4094","DOI":"10.1016\/j.vaccine.2008.03.099","volume":"26","author":"S Rathaur","year":"2008","unstructured":"Rathaur S, Yadav M, Gupta S, Anandharaman V, Reddy MV. Filarial glutathione-S-transferase: a potential vaccine candidate against lymphatic filariasis. Vaccine. 2008;26(32):4094\u2013100.","journal-title":"Vaccine"},{"key":"10272_CR22","unstructured":"Ellis RJ. Stress proteins as molecular chaperones. In Eden WV, Young DB, editors. Stress proteins in medicine. New York: Marcel Dekker; 1996. pp. 1\u201326."},{"issue":"8","key":"10272_CR23","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1002\/ddr.22003","volume":"83","author":"F Ahmad","year":"2022","unstructured":"Ahmad F, Sharma S, Yadav S, Rathaur S. The HSP90 inhibitor 17-AAG induced calcium\u2010mediated apoptosis in filarial parasites. Drug Dev Res. 2022;83(8):1867\u201378.","journal-title":"Drug Dev Res"},{"issue":"6","key":"10272_CR24","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1007\/s00204-021-03070-8","volume":"95","author":"BJ Lang","year":"2021","unstructured":"Lang BJ, Guerrero ME, Prince TL, Okusha Y, Bonorino C, Calderwood SK. The functions and regulation of heat shock proteins; key orchestrators of proteostasis and the heat shock response. Arch Toxicol. 2021;95(6):1943\u201370.","journal-title":"Arch Toxicol"},{"key":"10272_CR25","doi-asserted-by":"publisher","unstructured":"Chung M, Teigen LE, Libro S, Bromley RE, Olley D, Kumar N, Sadzewicz L, Tallon LJ, Mahurkar A, Foster JM. Drug repurposing of bromodomain inhibitors as potential novel therapeutic leads for lymphatic filariasis guided by multispecies transcriptomics. Msystems. 2019;4(6). https:\/\/doi.org\/10.1128\/msystems. 00596\u2009\u2013\u200900519.","DOI":"10.1128\/msystems"},{"key":"10272_CR26","doi-asserted-by":"publisher","first-page":"124320","DOI":"10.1016\/j.ijbiomac.2023.124320","volume":"239","author":"A Ullah","year":"2023","unstructured":"Ullah A, Waqas M, Aziz S, ur Rahman S, Khan S, Khalid A, Abdalla AN, Uddin J, Halim SA, Khan A. Bioinformatics and immunoinformatics approach to develop potent multi-peptide vaccine for coxsackievirus B3 capable of eliciting cellular and humoral immune response. Int J Biol Macromol. 2023;239:124320.","journal-title":"Int J Biol Macromol"},{"issue":"4","key":"10272_CR27","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.exppara.2004.12.003","volume":"109","author":"S Gupta","year":"2005","unstructured":"Gupta S, Bhandari YP, Reddy MV, Harinath BC, Rathaur S. Setaria Cervi: immunoprophylactic potential of glutathione-S-transferase against filarial parasite Brugia malayi. Exp Parasitol. 2005;109(4):252\u20135.","journal-title":"Exp Parasitol"},{"issue":"1\u20132","key":"10272_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.exppara.2004.01.001","volume":"106","author":"V Ravi","year":"2004","unstructured":"Ravi V, Kubofcik J, Bandopathyaya S, Geetha M, Narayanan R, Nutman T, Kaliraj P. Wuchereria bancrofti: cloning and characterization of heat shock protein 70 from the human lymphatic filarial parasite. Exp Parasitol. 2004;106(1\u20132):1\u201310.","journal-title":"Exp Parasitol"},{"key":"10272_CR29","doi-asserted-by":"crossref","unstructured":"Nielsen H. Predicting secretory proteins with SignalP. Methods Mol Biol. 2017;1611:59\u201373.","DOI":"10.1007\/978-1-4939-7015-5_6"},{"key":"10272_CR30","doi-asserted-by":"crossref","unstructured":"Almagro Armenteros JJ, S\u00f8nderby CK, S\u00f8nderby SK, Nielsen H, Winther O. DeepLoc: prediction of protein subcellular localization using deep learning. Bioinformatics. 2017;33(21):3387\u201395.","DOI":"10.1093\/bioinformatics\/btx431"},{"issue":"W1","key":"10272_CR31","doi-asserted-by":"publisher","first-page":"W24","DOI":"10.1093\/nar\/gkx346","volume":"45","author":"MC Jespersen","year":"2017","unstructured":"Jespersen MC, Peters B, Nielsen M, Marcatili P. BepiPred-2.0: improving sequence-based B-cell epitope prediction using conformational epitopes. Nucleic Acids Res. 2017;45(W1):W24\u20139.","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"10272_CR32","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.4049\/jimmunol.171.4.1741","volume":"171","author":"B Peters","year":"2003","unstructured":"Peters B, Bulik S, Tampe R, Van Endert PM, Holzh\u00fctter HG. Identifying MHC class I epitopes by predicting the TAP transport efficiency of epitope precursors. J Immunol (Baltimore Md: 1950). 2003;171(4):1741\u20139.","journal-title":"J Immunol (Baltimore Md: 1950)"},{"issue":"1","key":"10272_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2105-10-296","volume":"10","author":"M Nielsen","year":"2009","unstructured":"Nielsen M, Lund O. NN-align. An artificial neural network-based alignment algorithm for MHC class II peptide binding prediction. BMC Bioinformatics. 2009;10(1):1\u201310.","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"10272_CR34","doi-asserted-by":"publisher","first-page":"8285","DOI":"10.1038\/s41598-017-08842-w","volume":"7","author":"N Khatoon","year":"2017","unstructured":"Khatoon N, Pandey RK, Prajapati VK. Exploring Leishmania secretory proteins to design B and T cell multi-epitope subunit vaccine using immunoinformatics approach. Sci Rep. 2017;7(1):8285.","journal-title":"Sci Rep"},{"key":"10272_CR35","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.3389\/fimmu.2018.02213","volume":"9","author":"PP Kar","year":"2018","unstructured":"Kar PP, Srivastava A. Immuno-Informatics analysis to identify novel vaccine candidates and design of a Multi-epitope based vaccine candidate against Theileria parasites. Front Immunol. 2018;9:2213.","journal-title":"Front Immunol"},{"key":"10272_CR36","doi-asserted-by":"publisher","first-page":"104633","DOI":"10.1016\/j.meegid.2020.104633","volume":"87","author":"NC Das","year":"2021","unstructured":"Das NC, Patra R, Gupta PSS, Ghosh P, Bhattacharya M, Rana MK, Mukherjee S. Designing of a novel multi-epitope peptide based vaccine against Brugia malayi: an in silico approach. Infect Genet Evol. 2021;87:104633.","journal-title":"Infect Genet Evol"},{"key":"10272_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00894-014-2278-5","volume":"20","author":"I Dimitrov","year":"2014","unstructured":"Dimitrov I, Bangov I, Flower DR, Doytchinova I. AllerTOP v. 2\u2014a server for in silico prediction of allergens. J Mol Model. 2014;20:1\u20136.","journal-title":"J Mol Model"},{"issue":"23","key":"10272_CR38","doi-asserted-by":"publisher","first-page":"2936","DOI":"10.1093\/bioinformatics\/btq551","volume":"26","author":"CN Magnan","year":"2010","unstructured":"Magnan CN, Zeller M, Kayala MA, Vigil A, Randall A, Felgner PL, Baldi P. High-throughput prediction of protein antigenicity using protein microarray data. Bioinformatics. 2010;26(23):2936\u201343.","journal-title":"Bioinformatics"},{"issue":"19","key":"10272_CR39","doi-asserted-by":"publisher","first-page":"3098","DOI":"10.1093\/bioinformatics\/btx345","volume":"33","author":"M Hebditch","year":"2017","unstructured":"Hebditch M, Carballo-Amador MA, Charonis S, Curtis R, Warwicker J. Protein\u2013Sol: a web tool for predicting protein solubility from sequence. Bioinformatics. 2017;33(19):3098\u2013100.","journal-title":"Bioinformatics"},{"key":"10272_CR40","first-page":"531","volume":"112","author":"MR Wilkins","year":"1999","unstructured":"Wilkins MR, Gasteiger E, Bairoch A, Sanchez JC, Williams KL, Appel RD, Hochstrasser DF. Protein identification and analysis tools in the ExPASy server. Methods Mol Biology (Clifton NJ). 1999;112:531\u201352.","journal-title":"Methods Mol Biology (Clifton NJ)"},{"issue":"1","key":"10272_CR41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-016-0001-8","volume":"6","author":"S Wang","year":"2016","unstructured":"Wang S, Peng J, Ma J, Xu J. Protein secondary structure prediction using deep convolutional neural fields. Sci Rep. 2016;6(1):1\u201311.","journal-title":"Sci Rep"},{"issue":"4","key":"10272_CR42","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/nprot.2010.5","volume":"5","author":"A Roy","year":"2010","unstructured":"Roy A, Kucukural A, Zhang Y. I-TASSER: a unified platform for automated protein structure and function prediction. Nat Protoc. 2010;5(4):725\u201338.","journal-title":"Nat Protoc"},{"key":"10272_CR43","doi-asserted-by":"crossref","unstructured":"Wiederstein M, Sippl MJ. ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. Nucleic Acids Res. 2007;35(Web Server issue):W407\u201310.","DOI":"10.1093\/nar\/gkm290"},{"issue":"3","key":"10272_CR44","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1002\/prot.10286","volume":"50","author":"SC Lovell","year":"2003","unstructured":"Lovell SC, Davis IW, De Arendall PI III, Word JM, Prisant MG, Richardson JS, Richardson DC. Structure validation by C\u03b1 geometry: \u03d5, \u03c8 and C\u03b2 deviation. Proteins Struct Funct Bioinform. 2003;50(3):437\u201350.","journal-title":"Proteins Struct Funct Bioinform"},{"key":"10272_CR45","doi-asserted-by":"crossref","unstructured":"Malik M, Khan S, Ullah A, Hassan M, Haq MU, Ahmad S, Al-Harbi AI, Sanami S, Abideen SA, Irfan M et al. Proteome-wide screening of potential vaccine targets against Brucella melitensis. Vaccines 2023, 11(2).","DOI":"10.3390\/vaccines11020263"},{"key":"10272_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2105-14-S19-S1","volume":"14","author":"DB Craig","year":"2013","unstructured":"Craig DB, Dombkowski AA. Disulfide by Design 2.0: a web-based tool for disulfide engineering in proteins. BMC Bioinformatics. 2013;14:1\u20137.","journal-title":"BMC Bioinformatics"},{"issue":"W1","key":"10272_CR47","doi-asserted-by":"publisher","first-page":"W271","DOI":"10.1093\/nar\/gku339","volume":"42","author":"JR L\u00f3pez-Blanco","year":"2014","unstructured":"L\u00f3pez-Blanco JR, Aliaga JI, Quintana-Ort\u00ed ES, Chac\u00f3n P. iMODS: internal coordinates normal mode analysis server. Nucleic Acids Res. 2014;42(W1):W271\u20136.","journal-title":"Nucleic Acids Res"},{"key":"10272_CR48","doi-asserted-by":"publisher","first-page":"138894","DOI":"10.1016\/j.cplett.2021.138894","volume":"780","author":"RS Tumskiy","year":"2021","unstructured":"Tumskiy RS, Tumskaia AV. Multistep rational molecular design and combined docking for discovery of novel classes of inhibitors of SARS-CoV-2 main protease 3CLpro. Chem Phys Lett. 2021;780:138894.","journal-title":"Chem Phys Lett"},{"issue":"suppl2","key":"10272_CR49","doi-asserted-by":"publisher","first-page":"W526","DOI":"10.1093\/nar\/gki376","volume":"33","author":"A Grote","year":"2005","unstructured":"Grote A, Hiller K, Scheer M, M\u00fcnch R, N\u00f6rtemann B, Hempel DC, Jahn D. JCat: a novel tool to adapt codon usage of a target gene to its potential expression host. Nucleic Acids Res. 2005;33(suppl2):W526\u201331.","journal-title":"Nucleic Acids Res"},{"key":"10272_CR50","doi-asserted-by":"publisher","first-page":"172","DOI":"10.3389\/fmicb.2014.00172","volume":"5","author":"GL Rosano","year":"2014","unstructured":"Rosano GL, Ceccarelli EA. Recombinant protein expression in Escherichia coli: advances and challenges. Front Microbiol. 2014;5:172.","journal-title":"Front Microbiol"},{"issue":"1","key":"10272_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.gene.2016.02.047","volume":"584","author":"S Morla","year":"2016","unstructured":"Morla S, Makhija A, Kumar S. Synonymous codon usage pattern in glycoprotein gene of Rabies virus. Gene. 2016;584(1):1\u20136.","journal-title":"Gene"},{"issue":"1","key":"10272_CR52","doi-asserted-by":"publisher","first-page":"17617","DOI":"10.1038\/s41598-020-74091-z","volume":"10","author":"H Fu","year":"2020","unstructured":"Fu H, Liang Y, Zhong X, Pan Z, Huang L, Zhang H, Xu Y, Zhou W, Liu Z. Codon optimization with deep learning to enhance protein expression. Sci Rep. 2020;10(1):17617.","journal-title":"Sci Rep"},{"issue":"4","key":"10272_CR53","doi-asserted-by":"publisher","first-page":"e9862","DOI":"10.1371\/journal.pone.0009862","volume":"5","author":"N Rapin","year":"2010","unstructured":"Rapin N, Lund O, Bernaschi M, Castiglione F. Computational immunology meets bioinformatics: the use of prediction tools for molecular binding in the simulation of the immune system. PLoS ONE. 2010;5(4):e9862.","journal-title":"PLoS ONE"},{"issue":"12","key":"10272_CR54","doi-asserted-by":"publisher","first-page":"e0244176","DOI":"10.1371\/journal.pone.0244176","volume":"15","author":"M Tahir ul Qamar","year":"2020","unstructured":"Tahir ul Qamar M, Rehman A, Tusleem K, Ashfaq UA, Qasim M, Zhu X, Fatima I, Shahid F, Chen L-L. Designing of a next generation multiepitope based vaccine (MEV) against SARS-COV-2: Immunoinformatics and in silico approaches. PLoS ONE. 2020;15(12):e0244176.","journal-title":"PLoS ONE"},{"issue":"2","key":"10272_CR55","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.bbrc.2007.02.147","volume":"356","author":"S Gupta","year":"2007","unstructured":"Gupta S, Singh A, Yadav M, Singh K, Rathaur S. MALDI mass sequencing and characterization of filarialglutathione-S-transferase. Biochem Biophys Res Commun. 2007;356(2):381\u20135.","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"10272_CR56","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1016\/j.bbrc.2005.03.235","volume":"331","author":"A Singh","year":"2005","unstructured":"Singh A, Rathaur S. Identification and characterization of a selenium-dependent glutathione peroxidase in Setaria Cervi. Biochem Biophys Res Commun. 2005;331(4):1069\u201374.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10272_CR57","first-page":"35","volume":"39","author":"S Rathaur","year":"2001","unstructured":"Rathaur S, Sharma S, Singh RN, Henkle K, Selkirk ME. Antibody responses of Wuchereria bancrofti patients to recombinant Brugia pahangi superoxide dismutase. Indian J Exp Biol. 2001;39(1):35\u201340.","journal-title":"Indian J Exp Biol"},{"issue":"5","key":"10272_CR58","doi-asserted-by":"publisher","first-page":"e12978","DOI":"10.1111\/pim.12978","volume":"45","author":"F Ahmad","year":"2023","unstructured":"Ahmad F, Liebau E, Rathaur S. Human immune response against filarial HSP70 and its role in the diagnosis of lymphatic filariasis. Parasite Immunol. 2023;45(5):e12978.","journal-title":"Parasite Immunol"},{"issue":"8","key":"10272_CR59","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1002\/ddr.22003","volume":"83","author":"F Ahmad","year":"2022","unstructured":"Ahmad F, Sharma S, Yadav S, Rathaur S. The HSP90 inhibitor 17-AAG induced calcium-mediated apoptosis in filarial parasites. Drug Dev Res. 2022;83(8):1867\u201378.","journal-title":"Drug Dev Res"},{"issue":"3","key":"10272_CR60","doi-asserted-by":"publisher","first-page":"215","DOI":"10.2217\/imt-2018-0105","volume":"11","author":"A Milani","year":"2019","unstructured":"Milani A, Basirnejad M, Bolhassani A. Heat-shock proteins in diagnosis and treatment: an overview of different biochemical and immunological functions. Immunotherapy. 2019;11(3):215\u201339.","journal-title":"Immunotherapy"},{"key":"10272_CR61","doi-asserted-by":"crossref","unstructured":"Yazdani Z, Rafiei A, Yazdani M, Valadan R. Design an efficient multi-epitope peptide vaccine candidate against SARS-CoV-2: an in silico analysis. Infect Drug Resist. 2020;13:3007\u201322.","DOI":"10.2147\/IDR.S264573"},{"issue":"19","key":"10272_CR62","doi-asserted-by":"publisher","first-page":"8808","DOI":"10.1080\/07391102.2021.1918252","volume":"40","author":"NC Das","year":"2022","unstructured":"Das NC, Sen Gupta PS, Biswal S, Patra R, Rana MK, Mukherjee S. In-silico evidences on filarial cystatin as a putative ligand of human TLR4. J Biomol Struct Dyn. 2022;40(19):8808\u201324.","journal-title":"J Biomol Struct Dyn"},{"issue":"4","key":"10272_CR63","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1111\/pim.12093","volume":"36","author":"W Hartmann","year":"2014","unstructured":"Hartmann W, Singh N, Rathaur S, Brenz Y, Liebau E, Fleischer B, Breloer M. Immunization with B rugia malayi Hsp70 protects mice against L itomosoides sigmodontis challenge infection. Parasite Immunol. 2014;36(4):141\u20139.","journal-title":"Parasite Immunol"},{"key":"10272_CR64","doi-asserted-by":"crossref","unstructured":"Ullah A, Rehman B, Khan S, Almanaa TN, Waheed Y, Hassan M, Naz T, Ul Haq M, Muhammad R, Sanami S et al. An In Silico Multi-epitopes Vaccine Ensemble and Characterization Against Nosocomial Proteus penneri. Molecular biotechnology 2023.","DOI":"10.1007\/s12033-023-00949-y"},{"issue":"8","key":"10272_CR65","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.trstmh.2010.02.007","volume":"104","author":"A Singh","year":"2010","unstructured":"Singh A, Kamal S, Rathaur S. Filarial selenium glutathione peroxidase: a probable immunodiagnostic marker for lymphatic filariasis. Trans R Soc Trop Med Hyg. 2010;104(8):524\u20138.","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10272_CR66","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1590\/S0074-02762004000900007","volume":"99","author":"PT LoVerde","year":"2004","unstructured":"LoVerde PT, Carvalho-Queiroz C, Cook R. Vaccination with antioxidant enzymes confers protective immunity against challenge infection with Schistosoma mansoni. Mem\u00f3rias do Instituto Oswaldo Cruz. 2004;99:37\u201343.","journal-title":"Mem\u00f3rias do Instituto Oswaldo Cruz"},{"issue":"29\u201330","key":"10272_CR67","doi-asserted-by":"publisher","first-page":"3705","DOI":"10.1016\/j.vaccine.2008.04.061","volume":"26","author":"S Dabir","year":"2008","unstructured":"Dabir S, Dabir P, Goswamy K, Reddy M. Prophylactic evaluation of recombinant extracellular superoxide dismutase of Brugia malayi in jird model. Vaccine. 2008;26(29\u201330):3705\u201310.","journal-title":"Vaccine"},{"issue":"6","key":"10272_CR68","doi-asserted-by":"publisher","first-page":"e457","DOI":"10.1371\/journal.pntd.0000457","volume":"3","author":"A Veerapathran","year":"2009","unstructured":"Veerapathran A, Dakshinamoorthy G, Gnanasekar M, Reddy MVR, Kalyanasundaram R. Evaluation of Wuchereria bancrofti GST as a vaccine candidate for lymphatic filariasis. PLoS Negl Trop Dis. 2009;3(6):e457.","journal-title":"PLoS Negl Trop Dis"},{"key":"10272_CR69","doi-asserted-by":"publisher","first-page":"2698","DOI":"10.3389\/fimmu.2019.02698","volume":"10","author":"L Michel-Tod\u00f3","year":"2019","unstructured":"Michel-Tod\u00f3 L, Reche PA, Bigey P, Pinazo MJ, Gasc\u00f3n J, Alonso-Padilla J. In silico design of an epitope-based Vaccine Ensemble for Chagas Disease. Front Immunol. 2019;10:2698.","journal-title":"Front Immunol"},{"issue":"6","key":"10272_CR70","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.3390\/cells10061508","volume":"10","author":"SA Slamanig","year":"2021","unstructured":"Slamanig SA, Nolte MA. The bone marrow as sanctuary for plasma cells and memory T-cells: implications for adaptive immunity and vaccinology. Cells. 2021;10(6):1508.","journal-title":"Cells"},{"issue":"31","key":"10272_CR71","doi-asserted-by":"publisher","first-page":"4015","DOI":"10.1016\/j.jchromb.2009.10.009","volume":"877","author":"YJ Wu","year":"2009","unstructured":"Wu YJ, Fan CY, Li YK. Protein purification involving a unique auto-cleavage feature of a repeated EAAAK peptide. J Chromatogr B Anal Technol Biomedical life Sci. 2009;877(31):4015\u201321.","journal-title":"J Chromatogr B Anal Technol Biomedical life Sci"},{"issue":"6","key":"10272_CR72","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1002\/jmv.25736","volume":"92","author":"M Bhattacharya","year":"2020","unstructured":"Bhattacharya M, Sharma AR, Patra P, Ghosh P, Sharma G, Patra BC, Lee SS, Chakraborty C. Development of epitope-based peptide vaccine against novel coronavirus 2019 (SARS\u2010COV\u20102): Immunoinformatics approach. J Med Virol. 2020;92(6):618\u201331.","journal-title":"J Med Virol"},{"issue":"2","key":"10272_CR73","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1111\/j.1365-2249.1994.tb06548.x","volume":"96","author":"P Soboslay","year":"1994","unstructured":"Soboslay P, L\u00fcder C, Hoffmann W, Michaelis I, Helling G, Heuschkel C, Dreweck C, Blanke C, Pritze S, Banla M. Ivermectin-facilitated immunity in onchocerciasis; activation of parasite\u2010specific Th1\u2010type responses with subclinical Onchocerca volvulus infection. Clin Experimental Immunol. 1994;96(2):238\u201344.","journal-title":"Clin Experimental Immunol"},{"key":"10272_CR74","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/s12026-008-8079-0","volume":"43","author":"PG Venugopal","year":"2009","unstructured":"Venugopal PG, Nutman TB, Semnani RT. Activation and regulation of toll-like receptors (TLRs) by helminth parasites. Immunol Res. 2009;43:252\u201363.","journal-title":"Immunol Res"},{"issue":"5","key":"10272_CR75","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/nm1589","volume":"13","author":"H Kanzler","year":"2007","unstructured":"Kanzler H, Barrat FJ, Hessel EM, Coffman RL. Therapeutic targeting of innate immunity with toll-like receptor agonists and antagonists. Nat Med. 2007;13(5):552\u20139.","journal-title":"Nat Med"},{"issue":"6","key":"10272_CR76","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1093\/infdis\/jix067","volume":"215","author":"S Mukherjee","year":"2017","unstructured":"Mukherjee S, Mukherjee S, Maiti TK, Bhattacharya S, Sinha Babu SP. A novel ligand of toll-like receptor 4 from the Sheath of Wuchereria bancrofti Microfilaria induces Proinflammatory Response in macrophages. J Infect Dis. 2017;215(6):954\u201365.","journal-title":"J Infect Dis"},{"key":"10272_CR77","doi-asserted-by":"crossref","unstructured":"Fouzder C, Mukhuty A, Das S, Chattopadhyay D. TLR signaling on protozoan and helminthic parasite infection. Toll-like Receptors; 2019.","DOI":"10.5772\/intechopen.84711"},{"key":"10272_CR78","doi-asserted-by":"publisher","first-page":"812774","DOI":"10.3389\/fimmu.2022.812774","volume":"13","author":"T Duan","year":"2022","unstructured":"Duan T, Du Y, Xing C, Wang HY, Wang RF. Toll-like receptor signaling and its role in cell-mediated immunity. Front Immunol. 2022;13:812774.","journal-title":"Front Immunol"},{"issue":"5","key":"10272_CR79","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1016\/j.biotechadv.2011.09.013","volume":"30","author":"R Chen","year":"2012","unstructured":"Chen R. Bacterial expression systems for recombinant protein production: E. Coli and beyond. Biotechnol Adv. 2012;30(5):1102\u20137.","journal-title":"Biotechnol Adv"},{"key":"10272_CR80","doi-asserted-by":"publisher","first-page":"829467","DOI":"10.3389\/fmed.2022.829467","volume":"9","author":"MA Soltan","year":"2022","unstructured":"Soltan MA, Behairy MY, Abdelkader MS, Albogami S, Fayad E, Eid RA, Darwish KM, Elhady SS, Lotfy AM, Alaa Eldeen M. In silico designing of an epitope-based vaccine against common E. Coli pathotypes. Front Med. 2022;9:829467.","journal-title":"Front Med"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-024-10272-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12879-024-10272-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-024-10272-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T12:03:55Z","timestamp":1734523435000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-024-10272-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,18]]},"references-count":80,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["10272"],"URL":"https:\/\/doi.org\/10.1186\/s12879-024-10272-9","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,18]]},"assertion":[{"value":"23 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study does not involve any human or animal subject.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1436"}}