{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T04:41:35Z","timestamp":1784349695549,"version":"3.55.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"DOI":"10.1186\/s12879-024-10302-6","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T11:30:31Z","timestamp":1735558231000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Accuracy of ESAT6-CFP10 skin test compared with tuberculin skin test in a healthy population: a randomized, blind, parallel controlled phase III clinical study"],"prefix":"10.1186","volume":"24","author":[{"given":"Xiaoyan","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixin","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbiao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihua","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,30]]},"reference":[{"key":"10302_CR1","unstructured":"Global tuberculosis report 2022. Geneva: World Health Organization; 2022."},{"key":"10302_CR2","doi-asserted-by":"publisher","first-page":"1247661","DOI":"10.3389\/fpubh.2023.1247661","volume":"11","author":"M Gabdullina","year":"2023","unstructured":"Gabdullina M, Maes EF, Horth RZ, et al. COVID-19 pandemic and other factors associated with unfavorable tuberculosis treatment outcomes-Almaty, Kazakhstan, 2018\u20132021. Front Public Health. 2023;11:1247661.","journal-title":"Front Public Health"},{"issue":"3","key":"10302_CR3","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1093\/cid\/ciaa1289","volume":"73","author":"Q Liu","year":"2021","unstructured":"Liu Q, Lu P, Shen Y, et al. Collateral impact of the Coronavirus Disease 2019 (COVID-19) pandemic on Tuberculosis Control in Jiangsu Province, China. Clin Infect Dis. 2021;73(3):542\u20134.","journal-title":"Clin Infect Dis"},{"key":"10302_CR4","doi-asserted-by":"crossref","unstructured":"Kargarpour Kamakoli M, Hadifar S, Khanipour S et al. Tuberculosis under the influence of COVID-19 lockdowns: lessons from Tehran. Iran mSphere. 2021. 6(1).","DOI":"10.1128\/mSphere.00076-21"},{"key":"10302_CR5","doi-asserted-by":"publisher","first-page":"100603","DOI":"10.1016\/j.eclinm.2020.100603","volume":"28","author":"L Cilloni","year":"2020","unstructured":"Cilloni L, Fu H, Vesga JF, et al. The potential impact of the COVID-19 pandemic on the tuberculosis epidemic a modelling analysis. EClinicalMedicine. 2020;28:100603.","journal-title":"EClinicalMedicine"},{"issue":"3","key":"10302_CR6","doi-asserted-by":"publisher","first-page":"e0000219","DOI":"10.1371\/journal.pgph.0000219","volume":"2","author":"R Martin-Hughes","year":"2022","unstructured":"Martin-Hughes R, Vu L, Cheikh N, et al. Impacts of COVID-19-related service disruptions on TB incidence and deaths in Indonesia, Kyrgyzstan, Malawi, Mozambique, and Peru: implications for national TB responses. PLOS Glob Public Health. 2022;2(3):e0000219.","journal-title":"PLOS Glob Public Health"},{"key":"10302_CR7","doi-asserted-by":"crossref","unstructured":"Trajman A, Steffen RE, Menzies D. Interferon-Gamma Release Assays versus Tuberculin Skin Testing for the Diagnosis of Latent Tuberculosis Infection: An Overview of the Evidence. Pulm Med. 2013. 2013: 601737.","DOI":"10.1155\/2013\/601737"},{"issue":"12","key":"10302_CR8","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/S1473-3099(04)01206-X","volume":"4","author":"M Pai","year":"2004","unstructured":"Pai M, Riley LW, Colford JM Jr. Interferon-gamma assays in the immunodiagnosis of tuberculosis: a systematic review. Lancet Infect Dis. 2004;4(12):761\u201376.","journal-title":"Lancet Infect Dis"},{"issue":"4","key":"10302_CR9","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1093\/cid\/ciab472","volume":"74","author":"M Xu","year":"2022","unstructured":"Xu M, Lu W, Li T, et al. Sensitivity, specificity, and Safety of a Novel ESAT6-CFP10 skin test for tuberculosis infection in China: 2 Randomized, Self-Controlled, parallel-group phase 2b trials. Clin Infect Dis. 2022;74(4):668\u201377.","journal-title":"Clin Infect Dis"},{"key":"10302_CR10","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.ijid.2022.11.014","volume":"126","author":"L Xia","year":"2023","unstructured":"Xia L, Xu M, Li F, et al. High accuracy of recombinant fusion protein early secretory antigenic target protein 6-culture filtrate protein 10 skin test for the detection of tuberculosis infection: a phase III, multi-centered, double-blind, hospital-based, randomized controlled trial. Int J Infect Dis. 2023;126:98\u2013103.","journal-title":"Int J Infect Dis"},{"issue":"1","key":"10302_CR11","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1186\/s12879-022-07765-w","volume":"22","author":"Y Yang","year":"2022","unstructured":"Yang Y, Fang Z, Huang W, et al. Safety of a Novel ESAT6-CFP10 skin test compared with tuberculin skin test in a double-blind, randomized, controlled study. BMC Infect Dis. 2022;22(1):780.","journal-title":"BMC Infect Dis"},{"issue":"1","key":"10302_CR12","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1186\/s12879-020-05413-9","volume":"20","author":"H Zhang","year":"2020","unstructured":"Zhang H, Wang L, Li F, Lu S, Xia J. Induration or erythema diameter not less than 5\u00a0mm as results of recombinant fusion protein ESAT6-CFP10 skin test for detecting M. Tuberculosis infection. BMC Infect Dis. 2020;20(1):685.","journal-title":"BMC Infect Dis"},{"issue":"9","key":"10302_CR13","doi-asserted-by":"publisher","first-page":"e0204554","DOI":"10.1371\/journal.pone.0204554","volume":"13","author":"H Aggerbeck","year":"2018","unstructured":"Aggerbeck H, Ruhwald M, Hoff ST, et al. C-Tb skin test to diagnose Mycobacterium tuberculosis infection in children and HIV-infected adults: a phase 3 trial. PLoS ONE. 2018;13(9):e0204554.","journal-title":"PLoS ONE"},{"issue":"4","key":"10302_CR14","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/S2213-2600(16)30436-2","volume":"5","author":"M Ruhwald","year":"2017","unstructured":"Ruhwald M, Aggerbeck H, Gallardo RV, et al. Safety and efficacy of the C-Tb skin test to diagnose Mycobacterium tuberculosis infection, compared with an interferon \u03b3 release assay and the tuberculin skin test: a phase 3, double-blind, randomised, controlled trial. Lancet Respir Med. 2017;5(4):259\u201368.","journal-title":"Lancet Respir Med"},{"issue":"12","key":"10302_CR15","doi-asserted-by":"publisher","first-page":"e0208705","DOI":"10.1371\/journal.pone.0208705","volume":"13","author":"L Slogotskaya","year":"2018","unstructured":"Slogotskaya L, Bogorodskaya E, Ivanova D, Sevostyanova T. Comparative sensitivity of the test with tuberculosis recombinant allergen, containing ESAT6-CFP10 protein, and Mantoux test with 2 TU PPD-L in newly diagnosed tuberculosis children and adolescents in Moscow. PLoS ONE. 2018;13(12):e0208705.","journal-title":"PLoS ONE"},{"issue":"2","key":"10302_CR16","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/S1473-3099(21)00261-9","volume":"22","author":"M Krutikov","year":"2022","unstructured":"Krutikov M, Faust L, Nikolayevskyy V, et al. The diagnostic performance of novel skin-based in-vivo tests for tuberculosis infection compared with purified protein derivative tuberculin skin tests and blood-based in vitro interferon-\u03b3 release assays: a systematic review and meta-analysis. Lancet Infect Dis. 2022;22(2):250\u201364.","journal-title":"Lancet Infect Dis"},{"issue":"11","key":"10302_CR17","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1111\/j.1469-0691.2004.00970.x","volume":"10","author":"K Hizel","year":"2004","unstructured":"Hizel K, Maral I, Karakus R, Aktas F. The influence of BCG immunisation on tuberculin reactivity and booster effect in adults in a country with a high prevalence of tuberculosis. Clin Microbiol Infect. 2004;10(11):980\u20133.","journal-title":"Clin Microbiol Infect"},{"issue":"6","key":"10302_CR18","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1164\/ajrccm.164.6.2102076","volume":"164","author":"D Singh","year":"2001","unstructured":"Singh D, Sutton C, Woodcock A. Repeat tuberculin testing in BCG-vaccinated subjects in the United Kingdom. The booster effect varies with the time of reading. Am J Respir Crit Care Med. 2001;164(6):962\u20134.","journal-title":"Am J Respir Crit Care Med"},{"issue":"8","key":"10302_CR19","first-page":"387","volume":"77","author":"IR Friedland","year":"1990","unstructured":"Friedland IR. The booster effect with repeat tuberculin testing in children and its relationship to BCG vaccination. S Afr Med J. 1990;77(8):387\u20139.","journal-title":"S Afr Med J"},{"issue":"3","key":"10302_CR20","doi-asserted-by":"publisher","first-page":"190","DOI":"10.7326\/0003-4819-120-3-199402010-00003","volume":"120","author":"R Menzies","year":"1994","unstructured":"Menzies R, Vissandjee B, Rocher I, St Germain Y. The booster effect in two-step tuberculin testing among young adults in Montreal. Ann Intern Med. 1994;120(3):190\u20138.","journal-title":"Ann Intern Med"},{"issue":"1","key":"10302_CR21","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1164\/ajrccm.159.1.9801120","volume":"159","author":"D Menzies","year":"1999","unstructured":"Menzies D. Interpretation of repeated tuberculin tests. Boosting, conversion, and reversion. Am J Respir Crit Care Med. 1999;159(1):15\u201321.","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"10302_CR22","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1164\/ajrccm\/145.3.621","volume":"145","author":"R Menzies","year":"1992","unstructured":"Menzies R, Vissandjee B. Effect of bacille Calmette-Gu\u00e9rin vaccination on tuberculin reactivity. Am Rev Respir Dis. 1992;145(3):621\u20135.","journal-title":"Am Rev Respir Dis"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-024-10302-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12879-024-10302-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-024-10302-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T12:02:40Z","timestamp":1735560160000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-024-10302-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,30]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["10302"],"URL":"https:\/\/doi.org\/10.1186\/s12879-024-10302-6","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,30]]},"assertion":[{"value":"11 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This experiment has been approved by Ethics Committee of Jiangsu Provincial Center for Disease Prevention and Control. The ethics approval number: JSJK2015-C018-02. The ethics approval date: November 17, 2015. All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration. Informed consent was obtained from all participants, in writing and dated, before enrollment in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not Applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1479"}}