{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:30:20Z","timestamp":1787020220816,"version":"build-2736575974"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100009329","name":"Scientific Research and Technology Development Program of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2023AB22055"],"award-info":[{"award-number":["2023AB22055"]}],"id":[{"id":"10.13039\/501100009329","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Central Leading Local Science and Technology Development Fund Project","award":["2023ZYZX1021"],"award-info":[{"award-number":["2023ZYZX1021"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"DOI":"10.1186\/s12879-025-10690-3","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:12Z","timestamp":1740441612000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical manifestations in patients with anti-IFN-\u03b3 autoantibodies syndrome and Talaromyces marneffei infection: a prospective cohort study"],"prefix":"10.1186","volume":"25","author":[{"given":"Hanlin","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqiao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiangxiu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengtao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaona","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"issue":"8","key":"10690_CR1","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1056\/NEJMoa1111160","volume":"367","author":"SK Browne","year":"2012","unstructured":"Browne SK, Burbelo PD, Chetchotisakd P, Suputtamongkol Y, Kiertiburanakul S, Shaw PA, Kirk JL, Jutivorakool K, Zaman R, Ding L, et al. Adult-onset immunodeficiency in Thailand and Taiwan. N Engl J Med. 2012;367(8):725\u201334.","journal-title":"N Engl J Med"},{"issue":"6693","key":"10690_CR2","doi-asserted-by":"publisher","first-page":"eadl2016","DOI":"10.1126\/science.adl2016","volume":"384","author":"JL Casanova","year":"2024","unstructured":"Casanova JL, MacMicking JD, Nathan CF. Interferon-\u03b3 and infectious diseases: lessons and prospects. Science. 2024;384(6693):eadl2016.","journal-title":"Science"},{"issue":"1","key":"10690_CR3","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1093\/cid\/ciz786","volume":"71","author":"GH Hong","year":"2020","unstructured":"Hong GH, Ortega-Villa AM, Hunsberger S, Chetchotisakd P, Anunnatsiri S, Mootsikapun P, Rosen LB, Zerbe CS, Holland SM. Natural history and evolution of Anti-Interferon-\u03b3 autoantibody-associated immunodeficiency syndrome in Thailand and the United States. Clin Infect Dis. 2020;71(1):53\u201362.","journal-title":"Clin Infect Dis"},{"issue":"7","key":"10690_CR4","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1007\/s10875-023-01537-0","volume":"43","author":"B Zhang","year":"2023","unstructured":"Zhang B, Fan J, Huang C, Fan H, Chen J, Huang X, Zeng X. Characteristics and outcomes of anti-interferon gamma antibody-associated adult onset immunodeficiency. J Clin Immunol. 2023;43(7):1660\u201370.","journal-title":"J Clin Immunol"},{"issue":"1","key":"10690_CR5","doi-asserted-by":"publisher","first-page":"e0005122","DOI":"10.1128\/cmr.00051-22","volume":"36","author":"F Wang","year":"2023","unstructured":"Wang F, Han R, Chen S. An overlooked and underrated endemic mycosis-talaromycosis and the pathogenic fungus talaromyces marneffei. Clin Microbiol Rev. 2023;36(1):e0005122.","journal-title":"Clin Microbiol Rev."},{"issue":"12","key":"10690_CR6","doi-asserted-by":"publisher","first-page":"e20190502","DOI":"10.1084\/jem.20190502","volume":"217","author":"J Guo","year":"2020","unstructured":"Guo J, Ning X-Q, Ding J-Y, Zheng Y-Q, Shi N-N, Wu F-Y, Lin Y-K, Shih H-P, Ting H-T, Liang G. Anti\u2013IFN-\u03b3 autoantibodies underlie disseminated Talaromyces marneffei infections. J Exp Med. 2020;217(12):e20190502.","journal-title":"J Exp Med."},{"key":"10690_CR7","first-page":"764293","volume":"2011","author":"SY Wong","year":"2011","unstructured":"Wong SY, Wong KF. Penicillium marneffei Infection in AIDS. Patholog Res Int. 2011;2011:764293.","journal-title":"Patholog Res Int"},{"issue":"1","key":"10690_CR8","first-page":"1","volume":"5","author":"JF Chan","year":"2016","unstructured":"Chan JF, Lau SK, Yuen K-Y, Woo PC. Talaromyces (Penicillium) marneffei infection in non-HIV-infected patients. Emerg Microbes Infect. 2016;5(1):1\u20139.","journal-title":"Emerg Microbes Infect"},{"issue":"5","key":"10690_CR9","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1007\/s40121-023-00801-5","volume":"12","author":"Q Yu","year":"2023","unstructured":"Yu Q, Wei M, Xiao R, Liang X, Liang S, Ma N, Wu S, Ning Y, Deng J, Yang M, et al. Clinical characteristics, course, and long-term outcomes in patients with talaromyces marneffei infection: a 10-year retrospective cohort study. Infect Dis Ther. 2023;12(5):1283\u201397.","journal-title":"Infect Dis Ther"},{"issue":"7","key":"10690_CR10","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1007\/s10096-024-04856-1","volume":"43","author":"X Zhang","year":"2024","unstructured":"Zhang X, Yao X, Chen H, Yang M, Han D. Clinical usefulness of metagenomic next-generation sequencing for Talaromyces marneffei diagnosis in China: a retrospective study. Eur J Clin Microbiol Infect Dis. 2024;43(7):1367\u201374.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10690_CR11","doi-asserted-by":"publisher","first-page":"987692","DOI":"10.3389\/fcimb.2022.987692","volume":"12","author":"L Liu","year":"2022","unstructured":"Liu L, Sun B, Ying W, Liu D, Wang Y, Sun J, Wang W, Yang M, Hui X, Zhou Q, et al. Rapid diagnosis of talaromyces marneffei infection by metagenomic next-generation sequencing technology in a Chinese cohort of inborn errors of immunity. Front Cell Infect Microbiol. 2022;12:987692.","journal-title":"Front Cell Infect Microbiol."},{"issue":"6","key":"10690_CR12","doi-asserted-by":"publisher","first-page":"647","DOI":"10.3390\/jof9060647","volume":"9","author":"SD Zaongo","year":"2023","unstructured":"Zaongo SD, Zhang F, Chen Y. An Overview of Diagnostic and Management Strategies for Talaromycosis, an Underrated Disease. J Fungi (Basel). 2023;9(6):647.","journal-title":"J Fungi (Basel)"},{"issue":"34","key":"10690_CR13","doi-asserted-by":"publisher","first-page":"e1439","DOI":"10.1097\/MD.0000000000001439","volume":"94","author":"W Zeng","year":"2015","unstructured":"Zeng W, Qiu Y, Lu D, Zhang J, Zhong X, Liu G. A retrospective analysis of 7 human immunodeficiency virus-negative infants infected by penicillium marneffei. Medicine (Baltimore). 2015;94(34):e1439.","journal-title":"Medicine (Baltimore)."},{"issue":"6","key":"10690_CR14","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/S0929-6646(08)60151-5","volume":"107","author":"IS Jan","year":"2008","unstructured":"Jan IS, Chung PF, Wang JY, Weng MH, Hung CC, Lee LN. Cytological diagnosis of Penicillium marneffei infection. J Formos Med Assoc. 2008;107(6):443\u20137.","journal-title":"J Formos Med Assoc"},{"issue":"24","key":"10690_CR15","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1056\/NEJMoa1613306","volume":"376","author":"T Le","year":"2017","unstructured":"Le T, Kinh NV, Cuc NTK, Tung NLN, Lam NT, Thuy PTT, Cuong DD, Phuc PTH, Vinh VH, Hanh DTH, et al. A trial of itraconazole or amphotericin B for HIV-associated talaromycosis. N Engl J Med. 2017;376(24):2329\u201340.","journal-title":"N Engl J Med"},{"issue":"1","key":"10690_CR16","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1128\/CMR.19.1.95-110.2006","volume":"19","author":"N Vanittanakom","year":"2006","unstructured":"Vanittanakom N, Cooper CR Jr, Fisher MC, Sirisanthana T. Penicillium marneffei infection and recent advances in the epidemiology and molecular biology aspects. Clin Microbiol Rev. 2006;19(1):95\u2013110.","journal-title":"Clin Microbiol Rev"},{"issue":"3","key":"10690_CR17","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.anai.2015.10.026","volume":"116","author":"BT Kelly","year":"2016","unstructured":"Kelly BT, Grayson MH. Immunoglobulin E, what is it good for? Ann Allergy Asthma Immunol. 2016;116(3):183\u20137.","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"Supplement 2","key":"10690_CR18","doi-asserted-by":"publisher","first-page":"S144","DOI":"10.1513\/AnnalsATS.201506-377AW","volume":"12","author":"EM Dunican","year":"2015","unstructured":"Dunican EM, Fahy JV. The role of type 2 inflammation in the pathogenesis of asthma exacerbations. Ann Am Thorac Soc. 2015;12(Supplement 2):S144\u20139.","journal-title":"Ann Am Thorac Soc"},{"key":"10690_CR19","doi-asserted-by":"publisher","first-page":"689","DOI":"10.3389\/fimmu.2018.00689","volume":"9","author":"M Maurer","year":"2018","unstructured":"Maurer M, Altrichter S, Schmetzer O, Scheffel J, Church MK, Metz M. Immunoglobulin E-mediated autoimmunity. Front Immunol. 2018;9:689.","journal-title":"Front Immunol"},{"issue":"4","key":"10690_CR20","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3390\/antib9040069","volume":"9","author":"Y Lamri","year":"2020","unstructured":"Lamri Y, Charles N. IgE in the pathogenesis of SLE: from pathogenic role to therapeutic target. Antibodies. 2020;9(4): 69.","journal-title":"Antibodies"},{"issue":"1","key":"10690_CR21","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1186\/s12879-021-06255-9","volume":"21","author":"Z-M Chen","year":"2021","unstructured":"Chen Z-M, Li Z-T, Li S-Q, Guan W-J, Qiu Y, Lei Z-Y, Zhan Y-Q, Zhou H, Lin S, Wang X. Clinical findings of Talaromyces marneffei infection among patients with anti-interferon-\u03b3 immunodeficiency: a prospective cohort study. BMC Infect Dis. 2021;21(1):587.","journal-title":"BMC Infect Dis"},{"issue":"4","key":"10690_CR22","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.jinf.2020.06.053","volume":"81","author":"Z Lin","year":"2020","unstructured":"Lin Z, Long F, Yang Y, Chen X, Xu L, Yang M. Serum ferritin as an independent risk factor for severity in COVID-19 patients. J Infect. 2020;81(4):647\u201379.","journal-title":"J Infect"},{"issue":"10","key":"10690_CR23","doi-asserted-by":"publisher","first-page":"e23618","DOI":"10.1002\/jcla.23618","volume":"34","author":"L Cheng","year":"2020","unstructured":"Cheng L, Li H, Li L, Liu C, Yan S, Chen H, Li Y. Ferritin in the coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis. J Clin Lab Anal. 2020;34(10):e23618.","journal-title":"J Clin Lab Anal"},{"issue":"8","key":"10690_CR24","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.bbagen.2010.03.011","volume":"1800","author":"W Wang","year":"2010","unstructured":"Wang W, Knovich MA, Coffman LG, Torti FM, Torti SV. Serum ferritin: past, present and future. Biochim Biophys Acta. 2010;1800(8):760\u20139.","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"10690_CR25","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1111\/bjh.15166","volume":"181","author":"JO Cullis","year":"2018","unstructured":"Cullis JO, Fitzsimons EJ, Griffiths WJ, Tsochatzis E, Thomas DW. Haematology BSf: Investigation and management of a raised serum ferritin. Br J Haematol. 2018;181(3):331\u201340.","journal-title":"Br J Haematol"},{"key":"10690_CR26","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jcrc.2017.03.025","volume":"40","author":"AF Talento","year":"2017","unstructured":"Talento AF, Dunne K, Joyce EA, Palmer M, Johnson E, White PL, Springer J, Loeffler J, Ryan T, Collins D, et al. A prospective study of fungal biomarkers to improve management of invasive fungal diseases in a mixed specialty critical care unit. J Crit Care. 2017;40:119\u201327.","journal-title":"J Crit Care"},{"issue":"36","key":"10690_CR27","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000021738","volume":"99","author":"XN Liang","year":"2020","unstructured":"Liang XN, Bin YF, Lai GT, Li YH, Zhang JQ, Zhong XN, Bai J, Li MH, Deng JM, He ZY. Non-tuberculous mycobacterial infection and reactive dermatosis associated with adult-onset immunodeficiency due to anti-interferon-gamma autoantibodies: a case report. Medicine (Baltimore). 2020;99(36):e21738.","journal-title":"Medicine (Baltimore)"},{"issue":"7","key":"10690_CR28","first-page":"441","volume":"18","author":"Q Su","year":"2015","unstructured":"Su Q, Ying G, Liang H, Ye L, Jiang J, Liang B, Huang J. Single use of Itraconazole has no effect on treatment for Penicillium Marneffei with HIV Infection. Arch Iran Med. 2015;18(7):441\u20135.","journal-title":"Arch Iran Med"},{"issue":"2\u20133","key":"10690_CR29","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s11046-021-00614-5","volume":"187","author":"X Xue","year":"2022","unstructured":"Xue X, Zou J, Fang W, Liu X, Chen M, Arastehfar A, Ilkit M, Zheng Y, Qin J, Peng Z, et al. Characteristics and prognosis of talaromyces marneffei infection in HIV-positive children in Southern China. Mycopathologia. 2022;187(2\u20133):169\u201380.","journal-title":"Mycopathologia"},{"issue":"2","key":"10690_CR30","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1055\/s-2008-1063858","volume":"29","author":"DI Zonios","year":"2008","unstructured":"Zonios DI, Bennett JE. Update on azole antifungals. Semin Respir Crit Care Med. 2008;29(2):198\u2013210.","journal-title":"Semin Respir Crit Care Med"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-025-10690-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12879-025-10690-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-025-10690-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:19Z","timestamp":1740441619000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-025-10690-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,25]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["10690"],"URL":"https:\/\/doi.org\/10.1186\/s12879-025-10690-3","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,25]]},"assertion":[{"value":"20 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of The First Affiliated Hospital of Guangxi Medical University (IRB Protocol Number: 2022-KT-Guike-127) and adhered to the Declaration of Helsinki. Informed consent was obtained from all patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"268"}}