{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:56:59Z","timestamp":1785884219553,"version":"3.56.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"DOI":"10.1186\/s12879-025-10950-2","type":"journal-article","created":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T10:28:06Z","timestamp":1745058486000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Increased risk during winter: common respiratory viruses and clinical outcomes in hospitalized children"],"prefix":"10.1186","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6702-8206","authenticated-orcid":false,"given":"Furkan","family":"Kalayci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aslinur","family":"Ozkaya Parlakay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3536-4456","authenticated-orcid":false,"given":"Metin","family":"Yigit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamze Nur","family":"G\u00fcler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bet\u00fcl","family":"Demircioglu Kalayci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aybuke Nur","family":"Cetin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve","family":"Dervisoglu Yurteri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ece","family":"Karakose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaan","family":"Celebier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naci","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orkun","family":"Tolunay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,19]]},"reference":[{"key":"10950_CR1","doi-asserted-by":"publisher","first-page":"349","DOI":"10.32641\/andespediatr.v92i3.1756","volume":"92","author":"LC Nicole","year":"2021","unstructured":"Nicole LC, Regina P, Cecilia V, Constanza MV, Tania L, Marcela M, et al. Relevance of codetection of respiratory viruses in the severity of acute respiratory infection in hospitalized children. Andes Pediatrica: Revista Chil De Pediatria. 2021;92:349\u201358.","journal-title":"Andes Pediatrica: Revista Chil De Pediatria"},{"key":"10950_CR2","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.jcv.2017.04.001","volume":"91","author":"P Loubet","year":"2017","unstructured":"Loubet P, Voiriot G, Houhou-Fidouh N, Neuville M, Bouadma L, Lescure FX, et al. Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: A single-center retrospective study. J Clin Virol. 2017;91:52\u20137.","journal-title":"J Clin Virol"},{"key":"10950_CR3","doi-asserted-by":"crossref","unstructured":"Kurskaya O, Ryabichenko T, Leonova N, Shi W, Bi H, Sharshov K et al. Viral etiology of acute respiratory infections in hospitalized children in Novosibirsk City, Russia (2013\u20132017). PLoS ONE. 2018;13.","DOI":"10.1101\/353037"},{"key":"10950_CR4","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1097\/01.inf.0000226912.88900.a3","volume":"25","author":"MMH Kusel","year":"2006","unstructured":"Kusel MMH, De Klerk NH, Holt PG, Kebadze T, Johnston SL, Sly PD. Role of respiratory viruses in acute upper and lower respiratory tract illness in the first year of life: a birth cohort study. Pediatr Infect Dis J. 2006;25:680\u20136.","journal-title":"Pediatr Infect Dis J"},{"key":"10950_CR5","doi-asserted-by":"crossref","unstructured":"Doan Q, Enarson P, Kissoon N, Klassen TP, Johnson DW. Rapid viral diagnosis for acute febrile respiratory illness in children in the emergency department. Cochrane Database Syst Rev. 2014;2014.","DOI":"10.1002\/14651858.CD006452.pub4"},{"key":"10950_CR6","doi-asserted-by":"publisher","first-page":"1003194","DOI":"10.1371\/journal.ppat.1003194","volume":"9","author":"JD Tamerius","year":"2013","unstructured":"Tamerius JD, Shaman J, Alonso WJ, Bloom-Feshbach K, Uejio CK, Comrie A, et al. Environmental predictors of seasonal influenza epidemics across temperate and tropical climates. PLoS Pathog. 2013;9:1003194.","journal-title":"PLoS Pathog"},{"key":"10950_CR7","doi-asserted-by":"crossref","unstructured":"Panozzo CA, Fowlkes AL, Anderson LJ. Variation in timing of respiratory syncytial virus outbreaks: lessons from National surveillance. Pediatr Infect Dis J. 2007;26 11 Suppl.","DOI":"10.1097\/INF.0b013e318157da82"},{"key":"10950_CR8","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1016\/S0140-6736(12)61901-1","volume":"381","author":"H Nair","year":"2013","unstructured":"Nair H, Sim\u00f5es EAF, Rudan I, Gessner BD, Azziz-Baumgartner E, Zhang JSF, et al. Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: a systematic analysis. Lancet. 2013;381:1380.","journal-title":"Lancet"},{"key":"10950_CR9","doi-asserted-by":"crossref","unstructured":"Wei L, Liu W, Zhang XA, Liu EM, Wo Y, Cowling BJ et al. Detection of viral and bacterial pathogens in hospitalized children with acute respiratory illnesses, Chongqing, 2009\u20132013. Medicine. 2015;94.","DOI":"10.1097\/MD.0000000000000742"},{"key":"10950_CR10","doi-asserted-by":"publisher","first-page":"408","DOI":"10.2471\/BLT.07.048769","volume":"86","author":"I Rudan","year":"2008","unstructured":"Rudan I, Boschi-Pinto C, Biloglav Z, Mulholland K, Campbell H. Epidemiology and etiology of childhood pneumonia. Bull World Health Organ. 2008;86:408.","journal-title":"Bull World Health Organ"},{"key":"10950_CR11","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.medin.2020.04.023","volume":"45","author":"M Duyu","year":"2021","unstructured":"Duyu M, Karakaya Z. Viral etiology and outcome of severe lower respiratory tract infections among critically ill children admitted to the PICU. Med Intensiva. 2021;45:447\u201358.","journal-title":"Med Intensiva"},{"key":"10950_CR12","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1002\/jmv.25502","volume":"91","author":"YT Li","year":"2019","unstructured":"Li YT, Liang Y, Ling YS, Duan MQ, Pan L, Chen ZG. The spectrum of viral pathogens in children with severe acute lower respiratory tract infection: A 3-year prospective study in the pediatric intensive care unit. J Med Virol. 2019;91:1633.","journal-title":"J Med Virol"},{"key":"10950_CR13","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1073\/pnas.1411030112","volume":"112","author":"EF Foxman","year":"2015","unstructured":"Foxman EF, Storer JA, Fitzgerald ME, Wasik BR, Hou L, Zhao H, et al. Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells. Proc Natl Acad Sci U S A. 2015;112:827\u201332.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10950_CR14","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1021\/mp0500465","volume":"2","author":"SF Ausar","year":"2005","unstructured":"Ausar SF, Rexroad J, Frolov VG, Look JL, Konar N, Middaugh CR. Analysis of the thermal and pH stability of human respiratory syncytial virus. Mol Pharm. 2005;2:491\u20139.","journal-title":"Mol Pharm"},{"key":"10950_CR15","doi-asserted-by":"crossref","unstructured":"Eifan SA, Hanif A, Aljohani SM, Atif M. Respiratory Tract Viral Infections and Coinfections Identified by Anyplex\u2122 II RV16 Detection Kit in Pediatric Patients at a Riyadh Tertiary Care Hospital. Biomed Res Int. 2017;2017.","DOI":"10.1155\/2017\/1928795"},{"key":"10950_CR16","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.jmii.2012.08.012","volume":"47","author":"YW Chen","year":"2014","unstructured":"Chen YW, Huang YC, Ho TH, Huang CG, Tsao KC, Lin TY. Viral etiology of bronchiolitis among pediatric inpatients in Northern Taiwan with emphasis on newly identified respiratory viruses. J Microbiol Immunol Infect. 2014;47:116.","journal-title":"J Microbiol Immunol Infect"},{"key":"10950_CR17","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/S2352-4642(19)30057-4","volume":"3","author":"A Christensen","year":"2019","unstructured":"Christensen A, Kesti O, Elenius V, Eskola AL, D\u00f8llner H, Altunbulakli C, et al. Human bocaviruses and paediatric infections. Lancet Child Adolesc Health. 2019;3:418\u201326.","journal-title":"Lancet Child Adolesc Health"},{"key":"10950_CR18","doi-asserted-by":"publisher","first-page":"e15102","DOI":"10.1111\/ped.15102","volume":"64","author":"D Ademhan Tural","year":"2022","unstructured":"Ademhan Tural D, Yalcin E, Emiralioglu N, Ozsezen B, Alp A, Sunman B, et al. Human bocavirus and human metapneumovirus in children with lower respiratory tract infections: effects on clinical, Microbiological features and disease severity. Pediatr Int. 2022;64:e15102.","journal-title":"Pediatr Int"},{"key":"10950_CR19","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.bjid.2018.05.004","volume":"22","author":"GF Biondo","year":"2018","unstructured":"Biondo GF, Santana JC, Lago PM, Piva J, Souza PRA, Gaulke JG, et al. Impact of A\/H1N1 influenza in children at a Brazilian university hospital. Brazilian J Infect Dis. 2018;22:219.","journal-title":"Brazilian J Infect Dis"},{"key":"10950_CR20","doi-asserted-by":"publisher","first-page":"MAY","DOI":"10.3389\/fimmu.2019.01231","volume":"10","author":"W Al-Herz","year":"2019","unstructured":"Al-Herz W, Essa S. Spectrum of viral infections among primary immunodeficient children: report from a National registry. Front Immunol. 2019;10:MAY.","journal-title":"Front Immunol"},{"issue":"Suppl 1","key":"10950_CR21","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1093\/infdis\/jiaa751","volume":"226","author":"T Shi","year":"2022","unstructured":"Shi T, Vennard S, Mahdy S, Nair H. Risk factors for poor outcome or death in young children with respiratory syncytial Virus-Associated acute lower respiratory tract infection: A systematic review and Meta-Analysis. J Infect Dis. 2022;226(Suppl 1):S10\u20136.","journal-title":"J Infect Dis"},{"key":"10950_CR22","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.earlhumdev.2015.06.009","volume":"91","author":"AM Helfrich","year":"2015","unstructured":"Helfrich AM, Nylund CM, Eberly MD, Eide MB, Stagliano DR. Healthy Late-preterm infants born 33\u201336 + 6 weeks gestational age have higher risk for respiratory syncytial virus hospitalization. Early Hum Dev. 2015;91:541\u20136.","journal-title":"Early Hum Dev"},{"key":"10950_CR23","doi-asserted-by":"publisher","first-page":"e17","DOI":"10.1111\/j.1651-2227.2011.02181.x","volume":"100","author":"P Papoff","year":"2011","unstructured":"Papoff P, Moretti C, Cangiano G, Bonci E, Roggini M, Pierangeli A, et al. Incidence and predisposing factors for severe disease in previously healthy term infants experiencing their first episode of bronchiolitis. Acta Paediatr. 2011;100:e17.","journal-title":"Acta Paediatr"},{"key":"10950_CR24","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1097\/PCC.0b013e3182257b82","volume":"13","author":"JA Farias","year":"2012","unstructured":"Farias JA, Fern\u00e1ndez A, Monteverde E, Flores JC, Baltodano A, Menchaca A, et al. Mechanical ventilation in pediatric intensive care units during the season for acute lower respiratory infection: a multicenter study. Pediatr Crit Care Med. 2012;13:158\u201364.","journal-title":"Pediatr Crit Care Med"},{"key":"10950_CR25","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1093\/tropej\/fmy010","volume":"65","author":"HK Hutton","year":"2019","unstructured":"Hutton HK, Zar HJ, Argent AC. Clinical features and outcome of children with severe lower respiratory tract infection admitted to a pediatric intensive care unit in South Africa. J Trop Pediatr. 2019;65:46\u201354.","journal-title":"J Trop Pediatr"},{"key":"10950_CR26","doi-asserted-by":"publisher","first-page":"e17780","DOI":"10.1371\/journal.pone.0017780","volume":"6","author":"AM Fry","year":"2011","unstructured":"Fry AM, Lu X, Olsen SJ, Chittaganpitch M, Sawatwong P, Chantra S, et al. Human rhinovirus infections in rural Thailand: epidemiological evidence for rhinovirus as both pathogen and bystander. PLoS ONE. 2011;6:e17780.","journal-title":"PLoS ONE"},{"key":"10950_CR27","doi-asserted-by":"crossref","unstructured":"Mohanty M, Mishra B, Satapathy AK, Gulla KM, Das RR, Dwibedi B et al. Human bocavirus infection in childhood acute respiratory infection: is it an innocent bystander? Indian J Med Microbiol. 2023;46.","DOI":"10.1016\/j.ijmmb.2023.100436"},{"key":"10950_CR28","doi-asserted-by":"crossref","unstructured":"Vandini S, Biagi C, Fischer M, Lanari M. Impact of rhinovirus infections in children. Viruses. 2019;11.","DOI":"10.3390\/v11060521"},{"key":"10950_CR29","doi-asserted-by":"crossref","unstructured":"Wen X, Huang Q, Tao H, Zou W, Gao M, Guo H et al. Clinical characteristics and viral etiologies of outpatients with acute respiratory infections in Huzhou of China: a retrospective study. BMC Infect Dis. 2019;19.","DOI":"10.1186\/s12879-018-3668-6"},{"key":"10950_CR30","doi-asserted-by":"crossref","unstructured":"Caporizzi A, Ravid\u00e0 F, Barneschi S, Moriondo M, Nieddu F, Boscia S et al. Analysis of a cohort of 165 pediatric patients with human bocavirus infection and comparison between Mono-Infection and respiratory Co-Infections: A retrospective study. Pathogens. 2024;13.","DOI":"10.3390\/pathogens13010055"},{"key":"10950_CR31","unstructured":"Tarihi G, Alkan S, Y\u0131lmaz \u00d6, Y\u00fcksel H et al. Bayar \u00dcniversitesi T\u0131p Fak\u00fcltesi C, Sa\u011fl\u0131\u011f\u0131 ve Hastal\u0131klar\u0131 \u00c7A,. New Et\u0131olog\u0131cal Agents Of Ch\u0131ldhood Lower Resp\u0131ratory Tract Infect\u0131ons. T\u00fcrkiye \u00c7ocuk Hastal\u0131klar\u0131 Dergisi. 2010;4:187\u201392."}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-025-10950-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12879-025-10950-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-025-10950-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T10:28:10Z","timestamp":1745058490000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-025-10950-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,19]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["10950"],"URL":"https:\/\/doi.org\/10.1186\/s12879-025-10950-2","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,19]]},"assertion":[{"value":"13 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with the ethical standards of the institutional and national research committees, and with the 1975 Helsinki Declaration and its later amendments. Ethical approval was granted by the Ethics Committee of Ankara Bilkent City Hospital. As the study was retrospective in nature, the requirement for obtaining informed consent from participants was waived by the Ethics Committee of Ankara Bilkent City Hospital, in accordance with. General consent for the use of medical records in research was obtained as part of the routine admission process where applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"No interventions were performed on any patients for the purposes of this study; only existing medical records were utilized. Data was anonymized and confidentiality was maintained in compliance with ethical standards. The information used was in accordance with the general consent provided by patients at the time of their admission to the hospital.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study does not involve any clinical trials. Therefore, no clinical trial registration is required.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial registration"}}],"article-number":"563"}}