{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:27:30Z","timestamp":1791300450457,"version":"4.1.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7202037"],"award-info":[{"award-number":["7202037"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"DOI":"10.1186\/s12879-025-10969-5","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T10:26:27Z","timestamp":1745317587000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between the (neutrophil\u2009+\u2009monocyte)\/albumin ratio and all-cause mortality in sepsis patients: a retrospective cohort study and predictive model establishment according to machine learning"],"prefix":"10.1186","volume":"25","author":[{"given":"Lulu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangzan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhou","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"issue":"3","key":"10969_CR1","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1164\/rccm.201504-0781OC","volume":"193","author":"C Fleischmann","year":"2016","unstructured":"Fleischmann C, Scherag A, Adhikari NK, Hartog CS, Tsaganos T, Schlattmann P, et al. Assessment of global incidence and mortality of Hospital-treated sepsis. Current estimates and limitations. Am J Respir Crit Care Med. 2016;193(3):259\u201372. https:\/\/doi.org\/10.1164\/rccm.201504-0781OC.","journal-title":"Am J Respir Crit Care Med"},{"issue":"8","key":"10969_CR2","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1007\/s00134-020-06151-x","volume":"46","author":"C Fleischmann-Struzek","year":"2020","unstructured":"Fleischmann-Struzek C, Mellhammar L, Rose N, Cassini A, Rudd KE, Schlattmann P, et al. Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis. Intensive Care Med. 2020;46(8):1552\u201362. https:\/\/doi.org\/10.1007\/s00134-020-06151-x.","journal-title":"Intensive Care Med"},{"issue":"10141","key":"10969_CR3","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/s0140-6736(18)30696-2","volume":"392","author":"M Cecconi","year":"2018","unstructured":"Cecconi M, Evans L, Levy M, Rhodes A. Sepsis and septic shock. Lancet (London England). 2018;392(10141):75\u201387. https:\/\/doi.org\/10.1016\/s0140-6736(18)30696-2.","journal-title":"Lancet (London England)"},{"issue":"10219","key":"10969_CR4","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/s0140-6736(19)32989-7","volume":"395","author":"KE Rudd","year":"2020","unstructured":"Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, et al. Global, regional, and National sepsis incidence and mortality, 1990\u20132017: analysis for the global burden of disease study. Lancet (London England). 2020;395(10219):200\u201311. https:\/\/doi.org\/10.1016\/s0140-6736(19)32989-7.","journal-title":"Lancet (London England)"},{"issue":"2","key":"10969_CR5","doi-asserted-by":"publisher","first-page":"e87","DOI":"10.52225\/narrax.v1i2.87","volume":"1","author":"Z Hayati","year":"2023","unstructured":"Hayati Z, Ismail YS, Suhartono S, Zikra M, Karmil TF, Oktiviyari A. Distribution and antimicrobial sensitivity pattern of multidrug-resistant *Pseudomonas aeruginosa* from the clinical specimen in Aceh. Indonesia *Narrax*. 2023;1(2):e87. https:\/\/doi.org\/10.52225\/narrax.v1i2.87.","journal-title":"Indonesia *Narrax*"},{"issue":"1","key":"10969_CR6","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.clnu.2018.08.037","volume":"38","author":"P Singer","year":"2019","unstructured":"Singer P, Blaser AR, Berger MM, Alhazzani W, Calder PC, Casaer MP, et al. ESPEN guideline on clinical nutrition in the intensive care unit. Clin Nutr. 2019;38(1):48\u201379. https:\/\/doi.org\/10.1016\/j.clnu.2018.08.037.","journal-title":"Clin Nutr"},{"key":"10969_CR7","doi-asserted-by":"publisher","unstructured":"Oh TK, Song IA. Prior evaluation of nutritional status and mortality in patients with Sepsis in South Korea. Nutrients. 2023;15(24). https:\/\/doi.org\/10.3390\/nu15245040.","DOI":"10.3390\/nu15245040"},{"issue":"7","key":"10969_CR8","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nri.2017.36","volume":"17","author":"T van der Poll","year":"2017","unstructured":"van der Poll T, van de Veerdonk FL, Scicluna BP, Netea MG. The immunopathology of sepsis and potential therapeutic targets. Nat Rev Immunol. 2017;17(7):407\u201320. https:\/\/doi.org\/10.1038\/nri.2017.36.","journal-title":"Nat Rev Immunol"},{"issue":"2 Suppl","key":"10969_CR9","doi-asserted-by":"publisher","first-page":"s447","DOI":"10.1093\/ajcn\/68.2.447S","volume":"68","author":"AH Shankar","year":"1998","unstructured":"Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr. 1998;68(2 Suppl):s447\u201363. https:\/\/doi.org\/10.1093\/ajcn\/68.2.447S.","journal-title":"Am J Clin Nutr"},{"issue":"11","key":"10969_CR10","doi-asserted-by":"publisher","first-page":"2450","DOI":"10.1016\/j.immuni.2021.10.012","volume":"54","author":"T van der Poll","year":"2021","unstructured":"van der Poll T, Shankar-Hari M, Wiersinga WJ. The immunology of sepsis. Immunity. 2021;54(11):2450\u201364. https:\/\/doi.org\/10.1016\/j.immuni.2021.10.012.","journal-title":"Immunity"},{"issue":"12","key":"10969_CR11","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1038\/nri3552","volume":"13","author":"RS Hotchkiss","year":"2013","unstructured":"Hotchkiss RS, Monneret G, Payen D. Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol. 2013;13(12):862\u201374. https:\/\/doi.org\/10.1038\/nri3552.","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"10969_CR12","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/nri1785","volume":"6","author":"C Nathan","year":"2006","unstructured":"Nathan C. Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol. 2006;6(3):173\u201382. https:\/\/doi.org\/10.1038\/nri1785.","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"10969_CR13","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1097\/00000658-198905000-00005","volume":"209","author":"WG Cheadle","year":"1989","unstructured":"Cheadle WG, Wilson M, Hershman MJ, Bergamini D, Richardson JD, Polk HC Jr. Comparison of trauma assessment scores and their use in prediction of infection and death. Ann Surg. 1989;209(5):541\u20135. https:\/\/doi.org\/10.1097\/00000658-198905000-00005. discussion 5\u20136.","journal-title":"Ann Surg"},{"issue":"7","key":"10969_CR14","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1007\/s001340051277","volume":"26","author":"AC Muller Kobold","year":"2000","unstructured":"Muller Kobold AC, Tulleken JE, Zijlstra JG, Sluiter W, Hermans J, Kallenberg CG, et al. Leukocyte activation in sepsis; correlations with disease state and mortality. Intensive Care Med. 2000;26(7):883\u201392. https:\/\/doi.org\/10.1007\/s001340051277.","journal-title":"Intensive Care Med"},{"issue":"4","key":"10969_CR15","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1097\/shk.0000000000001193","volume":"51","author":"H Chung","year":"2019","unstructured":"Chung H, Lee JH, Jo YH, Hwang JE, Kim J. Circulating monocyte counts and its impact on outcomes in patients with severe Sepsis including septic shock. Shock (Augusta Ga). 2019;51(4):423\u20139. https:\/\/doi.org\/10.1097\/shk.0000000000001193.","journal-title":"Shock (Augusta Ga)"},{"issue":"1","key":"10969_CR16","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1111\/j.1365-2249.2008.03737.x","volume":"154","author":"DD Danikas","year":"2008","unstructured":"Danikas DD, Karakantza M, Theodorou GL, Sakellaropoulos GC, Gogos CA. Prognostic value of phagocytic activity of neutrophils and monocytes in sepsis. Correlation to CD64 and CD14 antigen expression. Clin Exp Immunol. 2008;154(1):87\u201397. https:\/\/doi.org\/10.1111\/j.1365-2249.2008.03737.x.","journal-title":"Clin Exp Immunol"},{"key":"10969_CR17","doi-asserted-by":"publisher","first-page":"3578528","DOI":"10.1155\/2022\/3578528","volume":"2022","author":"S Li","year":"2022","unstructured":"Li S, Shen Y, Chang B, Wang N. Prognostic value of Albumin-to-Fibrinogen ratio for 28-Day mortality among patients with Sepsis from various infection sites. Mediat Inflamm. 2022;2022:3578528. https:\/\/doi.org\/10.1155\/2022\/3578528.","journal-title":"Mediat Inflamm"},{"issue":"4","key":"10969_CR18","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1007\/s10096-019-03478-2","volume":"38","author":"I Arnau-Barr\u00e9s","year":"2019","unstructured":"Arnau-Barr\u00e9s I, G\u00fcerri-Fern\u00e1ndez R, Luque S, Sorli L, V\u00e1zquez O, Miralles R. Serum albumin is a strong predictor of sepsis outcome in elderly patients. Eur J Clin Microbiol Infect Diseases: Official Publication Eur Soc Clin Microbiol. 2019;38(4):743\u20136. https:\/\/doi.org\/10.1007\/s10096-019-03478-2.","journal-title":"Eur J Clin Microbiol Infect Diseases: Official Publication Eur Soc Clin Microbiol"},{"issue":"6","key":"10969_CR19","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1080\/01443615.2022.2069484","volume":"42","author":"C Onal","year":"2022","unstructured":"Onal C, Gultekin M, Yavas G, Oymak E, Yuce Sari S, Guler OC, et al. The impact of serum albumin-to-alkaline phosphatase ratio in cervical cancer patients treated with definitive chemoradiotherapy. J Obstet Gynaecology: J Inst Obstet Gynecol. 2022;42(6):2426\u201332. https:\/\/doi.org\/10.1080\/01443615.2022.2069484.","journal-title":"J Obstet Gynaecology: J Inst Obstet Gynecol"},{"issue":"4","key":"10969_CR20","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.amjms.2020.07.020","volume":"361","author":"J Sun","year":"2021","unstructured":"Sun J, Su H, Lou Y, Wang M. Association between serum albumin level and All-Cause mortality in patients with chronic kidney disease: A retrospective cohort study. Am J Med Sci. 2021;361(4):451\u201360. https:\/\/doi.org\/10.1016\/j.amjms.2020.07.020.","journal-title":"Am J Med Sci"},{"issue":"6","key":"10969_CR21","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1007\/s00134-018-5208-7","volume":"44","author":"M Feng","year":"2018","unstructured":"Feng M, McSparron JI, Kien DT, Stone DJ, Roberts DH, Schwartzstein RM, et al. Transthoracic echocardiography and mortality in sepsis: analysis of the MIMIC-III database. Intensive Care Med. 2018;44(6):884\u201392. https:\/\/doi.org\/10.1007\/s00134-018-5208-7.","journal-title":"Intensive Care Med"},{"issue":"8","key":"10969_CR22","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for Sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801\u201310. https:\/\/doi.org\/10.1001\/jama.2016.0287.","journal-title":"JAMA"},{"issue":"1","key":"10969_CR23","doi-asserted-by":"publisher","first-page":"2212080","DOI":"10.1080\/0886022x.2023.2212080","volume":"45","author":"M Liang","year":"2023","unstructured":"Liang M, Ren X, Huang D, Ruan Z, Chen X, Qiu Z. The association between lactate dehydrogenase to serum albumin ratio and the 28-day mortality in patients with sepsis-associated acute kidney injury in intensive care: a retrospective cohort study. Ren Fail. 2023;45(1):2212080. https:\/\/doi.org\/10.1080\/0886022x.2023.2212080.","journal-title":"Ren Fail"},{"issue":"1","key":"10969_CR24","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1186\/s13054-024-05138-0","volume":"28","author":"C Guan","year":"2024","unstructured":"Guan C, Gong A, Zhao Y, Yin C, Geng L, Liu L, et al. Interpretable machine learning model for new-onset atrial fibrillation prediction in critically ill patients: a multi-center study. Crit Care (London England). 2024;28(1):349. https:\/\/doi.org\/10.1186\/s13054-024-05138-0.","journal-title":"Crit Care (London England)"},{"issue":"1","key":"10969_CR25","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1186\/s12967-022-03364-0","volume":"20","author":"S Yue","year":"2022","unstructured":"Yue S, Li S, Huang X, Liu J, Hou X, Zhao Y, et al. Machine learning for the prediction of acute kidney injury in patients with sepsis. J Translational Med. 2022;20(1):215. https:\/\/doi.org\/10.1186\/s12967-022-03364-0.","journal-title":"J Translational Med"},{"issue":"2","key":"10969_CR26","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1093\/bib\/bbx124","volume":"20","author":"F Degenhardt","year":"2019","unstructured":"Degenhardt F, Seifert S, Szymczak S. Evaluation of variable selection methods for random forests and omics data sets. Brief Bioinform. 2019;20(2):492\u2013503. https:\/\/doi.org\/10.1093\/bib\/bbx124.","journal-title":"Brief Bioinform"},{"issue":"1","key":"10969_CR27","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1186\/s12933-024-02462-1","volume":"23","author":"S Cheng","year":"2024","unstructured":"Cheng S, Shen H, Han Y, Han S, Lu Y. Association between stress hyperglycemia ratio index and all-cause mortality in critically ill patients with atrial fibrillation: a retrospective study using the MIMIC-IV database. Cardiovasc Diabetol. 2024;23(1):363. https:\/\/doi.org\/10.1186\/s12933-024-02462-1.","journal-title":"Cardiovasc Diabetol"},{"issue":"3","key":"10969_CR28","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/s41401-021-00676-7","volume":"43","author":"C Deng","year":"2022","unstructured":"Deng C, Zhao L, Yang Z, Shang JJ, Wang CY, Shen MZ, et al. Targeting HMGB1 for the treatment of sepsis and sepsis-induced organ injury. Acta Pharmacol Sin. 2022;43(3):520\u20138. https:\/\/doi.org\/10.1038\/s41401-021-00676-7.","journal-title":"Acta Pharmacol Sin"},{"issue":"2","key":"10969_CR29","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1097\/CCM.0b013e31827e83af","volume":"41","author":"RP Dellinger","year":"2013","unstructured":"Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013;41(2):580\u2013637. https:\/\/doi.org\/10.1097\/CCM.0b013e31827e83af.","journal-title":"Crit Care Med"},{"issue":"1","key":"10969_CR30","doi-asserted-by":"publisher","first-page":"e309","DOI":"10.52225\/narra.v4i1.309","volume":"4","author":"S Masyeni","year":"2024","unstructured":"Masyeni S, Wardhana IMW, Nainu F. Cytokine profiles in dengue fever and dengue hemorrhagic fever: A study from Indonesia. Narra J. 2024;4(1):e309. https:\/\/doi.org\/10.52225\/narra.v4i1.309.","journal-title":"Narra J"},{"issue":"1","key":"10969_CR31","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1378\/chest.112.1.235","volume":"112","author":"RC Bone","year":"1997","unstructured":"Bone RC, Grodzin CJ, Balk RA. Sepsis: a new hypothesis for pathogenesis of the disease process. Chest. 1997;112(1):235\u201343. https:\/\/doi.org\/10.1378\/chest.112.1.235.","journal-title":"Chest"},{"issue":"23","key":"10969_CR32","doi-asserted-by":"publisher","first-page":"2594","DOI":"10.1001\/jama.2011.1829","volume":"306","author":"JS Boomer","year":"2011","unstructured":"Boomer JS, To K, Chang KC, Takasu O, Osborne DF, Walton AH, et al. Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA. 2011;306(23):2594\u2013605. https:\/\/doi.org\/10.1001\/jama.2011.1829.","journal-title":"JAMA"},{"key":"10969_CR33","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.3389\/fimmu.2019.01560","volume":"10","author":"K Gao","year":"2019","unstructured":"Gao K, Jin J, Huang C, Li J, Luo H, Li L, et al. Exosomes derived from septic mouse serum modulate immune responses via Exosome-Associated cytokines. Front Immunol. 2019;10:1560. https:\/\/doi.org\/10.3389\/fimmu.2019.01560.","journal-title":"Front Immunol"},{"issue":"3","key":"10969_CR34","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s00134-010-2099-7","volume":"37","author":"PA Berry","year":"2011","unstructured":"Berry PA, Antoniades CG, Carey I, McPhail MJ, Hussain MJ, Davies ET, et al. Severity of the compensatory anti-inflammatory response determined by monocyte HLA-DR expression May assist outcome prediction in cirrhosis. Intensive Care Med. 2011;37(3):453\u201360. https:\/\/doi.org\/10.1007\/s00134-010-2099-7.","journal-title":"Intensive Care Med"},{"issue":"8","key":"10969_CR35","doi-asserted-by":"publisher","first-page":"e9859","DOI":"10.1097\/md.0000000000009859","volume":"97","author":"YC Wang","year":"2018","unstructured":"Wang YC, Liu QX, Liu T, Xu XE, Gao W, Bai XJ, et al. Caspase-1-dependent pyroptosis of peripheral blood mononuclear cells predicts the development of sepsis in severe trauma patients: A prospective observational study. Medicine. 2018;97(8):e9859. https:\/\/doi.org\/10.1097\/md.0000000000009859.","journal-title":"Medicine"},{"issue":"11","key":"10969_CR36","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1097\/01.ccm.0000145999.42971.4b","volume":"32","author":"F Venet","year":"2004","unstructured":"Venet F, Pachot A, Debard AL, Boh\u00e9 J, Bienvenu J, Lepape A, et al. Increased percentage of CD4\u2009+\u2009CD25\u2009+\u2009regulatory T cells during septic shock is due to the decrease of CD4\u2009+\u2009CD25- lymphocytes. Crit Care Med. 2004;32(11):2329\u201331. https:\/\/doi.org\/10.1097\/01.ccm.0000145999.42971.4b.","journal-title":"Crit Care Med"},{"issue":"1","key":"10969_CR37","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1186\/s12879-023-08680-4","volume":"23","author":"M Guo","year":"2023","unstructured":"Guo M, He W, Mao X, Luo Y, Zeng M. Association between ICU admission (neutrophil\u2009+\u2009monocyte)\/lymphocyte ratio and 30-day mortality in patients with sepsis: a retrospective cohort study. BMC Infect Dis. 2023;23(1):697. https:\/\/doi.org\/10.1186\/s12879-023-08680-4.","journal-title":"BMC Infect Dis"},{"key":"10969_CR38","doi-asserted-by":"publisher","unstructured":"De Simone G, di Masi A, Ascenzi P. Serum albumin: A multifaced enzyme. Int J Mol Sci. 2021;22(18). https:\/\/doi.org\/10.3390\/ijms221810086.","DOI":"10.3390\/ijms221810086"},{"key":"10969_CR39","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jcrc.2015.12.019","volume":"33","author":"A Artigas","year":"2016","unstructured":"Artigas A, Wernerman J, Arroyo V, Vincent JL, Levy M. Role of albumin in diseases associated with severe systemic inflammation: pathophysiologic and clinical evidence in sepsis and in decompensated cirrhosis. J Crit Care. 2016;33:62\u201370. https:\/\/doi.org\/10.1016\/j.jcrc.2015.12.019.","journal-title":"J Crit Care"},{"issue":"8","key":"10969_CR40","doi-asserted-by":"publisher","first-page":"e0136371","DOI":"10.1371\/journal.pone.0136371","volume":"10","author":"\u00c5 Norberg","year":"2015","unstructured":"Norberg \u00c5, Rooyackers O, Segersv\u00e4rd R, Wernerman J. Albumin kinetics in patients undergoing major abdominal surgery. PLoS ONE. 2015;10(8):e0136371. https:\/\/doi.org\/10.1371\/journal.pone.0136371.","journal-title":"PLoS ONE"},{"key":"10969_CR41","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.jcrc.2016.04.019","volume":"35","author":"JL Vincent","year":"2016","unstructured":"Vincent JL, De Backer D, Wiedermann CJ. Fluid management in sepsis: the potential beneficial effects of albumin. J Crit Care. 2016;35:161\u20137. https:\/\/doi.org\/10.1016\/j.jcrc.2016.04.019.","journal-title":"J Crit Care"},{"issue":"1","key":"10969_CR42","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1186\/s12877-019-1301-1","volume":"19","author":"W Huang","year":"2019","unstructured":"Huang W, Sun Y, Xing Y, Wang C. Functional impairment and serum albumin predict in-hospital mortality in nonagenarians with acute infection: a retrospective cohort study. BMC Geriatr. 2019;19(1):269. https:\/\/doi.org\/10.1186\/s12877-019-1301-1.","journal-title":"BMC Geriatr"},{"issue":"8","key":"10969_CR43","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1177\/08850666231170778","volume":"38","author":"L Geng","year":"2023","unstructured":"Geng L, Tian X, Gao Z, Mao A, Feng L, He C. Different concentrations of albumin versus crystalloid in patients with Sepsis and septic shock: A Meta-Analysis of randomized clinical trials. J Intensive Care Med. 2023;38(8):679\u201389. https:\/\/doi.org\/10.1177\/08850666231170778.","journal-title":"J Intensive Care Med"},{"issue":"1","key":"10969_CR44","doi-asserted-by":"publisher","first-page":"15309","DOI":"10.1038\/s41598-023-42601-4","volume":"13","author":"X Zhou","year":"2023","unstructured":"Zhou X, Fu S, Wu Y, Guo Z, Dian W, Sun H, et al. C-reactive protein-to-albumin ratio as a biomarker in patients with sepsis: a novel LASSO-COX based prognostic nomogram. Sci Rep. 2023;13(1):15309. https:\/\/doi.org\/10.1038\/s41598-023-42601-4.","journal-title":"Sci Rep"},{"key":"10969_CR45","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.3389\/fonc.2020.01617","volume":"10","author":"Y Pang","year":"2020","unstructured":"Pang Y, Shao H, Yang Z, Fan L, Liu W, Shi J, et al. The (Neutrophils\u2009+\u2009Monocyte)\/Lymphocyte ratio is an independent prognostic factor for Progression-Free survival in newly diagnosed multiple myeloma patients treated with BCD regimen. Front Oncol. 2020;10:1617. https:\/\/doi.org\/10.3389\/fonc.2020.01617.","journal-title":"Front Oncol"},{"key":"10969_CR46","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1093\/gerona\/glu057","volume":"69 Suppl 1","author":"C Franceschi","year":"2014","unstructured":"Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. Journals Gerontol Ser Biol Sci Med Sci. 2014;69 Suppl 1:S4\u20139. https:\/\/doi.org\/10.1093\/gerona\/glu057.","journal-title":"Journals Gerontol Ser Biol Sci Med Sci"},{"key":"10969_CR47","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.3389\/fimmu.2017.01960","volume":"8","author":"T Fulop","year":"2017","unstructured":"Fulop T, Larbi A, Dupuis G, Le Page A, Frost EH, Cohen AA, et al. Immunosenescence and Inflamm-Aging as two sides of the same coin: friends or foes?? Front Immunol. 2017;8:1960. https:\/\/doi.org\/10.3389\/fimmu.2017.01960.","journal-title":"Front Immunol"},{"issue":"1","key":"10969_CR48","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.maturitas.2015.02.009","volume":"81","author":"S Cabrerizo","year":"2015","unstructured":"Cabrerizo S, Cuadras D, Gomez-Busto F, Artaza-Artabe I, Mar\u00edn-Ciancas F, Malafarina V. Serum albumin and health in older people: review and meta analysis. Maturitas. 2015;81(1):17\u201327. https:\/\/doi.org\/10.1016\/j.maturitas.2015.02.009.","journal-title":"Maturitas"},{"issue":"10","key":"10969_CR49","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1038\/nri.2016.90","volume":"16","author":"SL Klein","year":"2016","unstructured":"Klein SL, Flanagan KL. Sex differences in immune responses. Nat Rev Immunol. 2016;16(10):626\u201338. https:\/\/doi.org\/10.1038\/nri.2016.90.","journal-title":"Nat Rev Immunol"},{"issue":"8","key":"10969_CR50","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/nri2815","volume":"10","author":"C Libert","year":"2010","unstructured":"Libert C, Dejager L, Pinheiro I. The X chromosome in immune functions: when a chromosome makes the difference. Nat Rev Immunol. 2010;10(8):594\u2013604. https:\/\/doi.org\/10.1038\/nri2815.","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"10969_CR51","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1210\/er.2007-0001","volume":"28","author":"RH Straub","year":"2007","unstructured":"Straub RH. The complex role of estrogens in inflammation. Endocr Rev. 2007;28(5):521\u201374. https:\/\/doi.org\/10.1210\/er.2007-0001.","journal-title":"Endocr Rev"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-025-10969-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12879-025-10969-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-025-10969-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T10:26:28Z","timestamp":1745317588000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-025-10969-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,22]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["10969"],"URL":"https:\/\/doi.org\/10.1186\/s12879-025-10969-5","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,22]]},"assertion":[{"value":"26 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study is based on the latest MIMIC-IV database (version 3.1). As the analysis utilized publicly available de-identified data, institutional review board approval at Beth Israel Deaconess Medical Center was waived, and informed consent was not required. The study was conducted in accordance with the principles of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"579"}}