{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:47:57Z","timestamp":1771051677368,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T00:00:00Z","timestamp":1745712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T00:00:00Z","timestamp":1745712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2022M710852"],"award-info":[{"award-number":["2022M710852"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82102420"],"award-info":[{"award-number":["82102420"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024QH034"],"award-info":[{"award-number":["ZR2024QH034"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"DOI":"10.1186\/s12879-025-10973-9","type":"journal-article","created":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T11:57:01Z","timestamp":1745755021000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phialophora americana infection in a patient with a compound heterozygous CARD9 mutation"],"prefix":"10.1186","volume":"25","author":[{"given":"Jie","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningning","family":"Dang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,27]]},"reference":[{"key":"10973_CR1","doi-asserted-by":"publisher","first-page":"895329","DOI":"10.3389\/fcimb.2022.895329","volume":"12","author":"Y He","year":"2022","unstructured":"He Y, Zheng HL, Mei H, Lv GX, Liu WD, Li XF. Phaeohyphomycosis in China. Front Cell Infect Microbiol. 2022;12:895329.","journal-title":"Front Cell Infect Microbiol"},{"issue":"4","key":"10973_CR2","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1128\/CMR.00019-10","volume":"23","author":"SG Revankar","year":"2010","unstructured":"Revankar SG, Sutton DA. Melanized fungi in human disease. Clin Microbiol Rev. 2010;23(4):884\u2013928.","journal-title":"Clin Microbiol Rev"},{"issue":"1","key":"10973_CR3","first-page":"205511692210776","volume":"8","author":"P Borr\u00e1s","year":"2022","unstructured":"Borr\u00e1s P, Messina F, Abrantes R, Iachini R, Minatel L, Santiso G. First report of phaeohyphomycosis caused by Phialophora americana in a domestic cat from Argentina. JFMS Open Rep. 2022;8(1):20551169221077611.","journal-title":"JFMS Open Rep"},{"issue":"5","key":"10973_CR4","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1111\/vde.13096","volume":"33","author":"F Martini","year":"2022","unstructured":"Martini F, Seehusen F, Krudewig C, Beckmann KM, Favrot C, Fischer NM, et al. Phaeohyphomycosis caused by Phialophora americana in a dog. Vet Dermatol. 2022;33(5):446\u20139.","journal-title":"Vet Dermatol"},{"key":"10973_CR5","doi-asserted-by":"crossref","unstructured":"Ahmed SA, Bonifaz A, Gonz\u00e1lez GM, Moreno LF, Menezes da Silva N, Vicente VA et al. Chromoblastomycosis caused by Phialophora-proven cases from Mexico. J Fungi (Basel). 2021;7(2).","DOI":"10.3390\/jof7020095"},{"issue":"10","key":"10973_CR6","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1111\/myc.12962","volume":"62","author":"C Huang","year":"2019","unstructured":"Huang C, Zhang Y, Song Y, Wan Z, Wang X, Li R. Phaeohyphomycosis caused by Phialophora americana with CARD9 mutation and 20-year literature review in China. Mycoses. 2019;62(10):908\u201319.","journal-title":"Mycoses"},{"key":"10973_CR7","doi-asserted-by":"publisher","first-page":"2434","DOI":"10.3389\/fmicb.2018.02434","volume":"9","author":"A Vaezi","year":"2018","unstructured":"Vaezi A, Fakhim H, Abtahian Z, Khodavaisy S, Geramishoar M, Alizadeh A, et al. Frequency and geographic distribution of CARD9 mutations in patients with severe fungal infections. Front Microbiol. 2018;9:2434.","journal-title":"Front Microbiol"},{"key":"10973_CR8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3389\/fcimb.2016.00039","volume":"6","author":"RA Drummond","year":"2016","unstructured":"Drummond RA, Lionakis MS. Mechanistic insights into the role of C-Type lectin receptor\/CARD9 signaling in human antifungal immunity. Front Cell Infect Microbiol. 2016;6:39.","journal-title":"Front Cell Infect Microbiol"},{"key":"10973_CR9","doi-asserted-by":"publisher","first-page":"1021837","DOI":"10.3389\/fmicb.2022.1021837","volume":"13","author":"A Hu","year":"2022","unstructured":"Hu A, Hu Z, Zou H, Zhang J, Zhang D, Wang H, et al. CARD9 in host immunity to fungal, bacterial, viral, and parasitic infections: an update. Front Microbiol. 2022;13:1021837.","journal-title":"Front Microbiol"},{"issue":"2","key":"10973_CR10","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1007\/s10875-021-01173-6","volume":"42","author":"S Goel","year":"2022","unstructured":"Goel S, Kuehn HS, Chinen J, Niemela J, Stoddard J, Yamanaka D, et al. CARD9 expression pattern, gene dosage, and immunodeficiency phenotype revisited. J Clin Immunol. 2022;42(2):336\u201349.","journal-title":"J Clin Immunol"},{"key":"10973_CR11","doi-asserted-by":"publisher","first-page":"984093","DOI":"10.3389\/fimmu.2022.984093","volume":"13","author":"C Huang","year":"2022","unstructured":"Huang C, Deng W, Zhang Y, Zhang K, Ma Y, Song Y, et al. CARD9 deficiency predisposing chromoblastomycosis: a case report and comparative transcriptome study. Front Immunol. 2022;13:984093.","journal-title":"Front Immunol"},{"key":"10973_CR12","doi-asserted-by":"publisher","first-page":"1492000","DOI":"10.3389\/fimmu.2025.1492000","volume":"16","author":"H Fan","year":"2025","unstructured":"Fan H, Yang Z, Wu Y, Lu X, Li T, Lu X, et al. Human inborn errors of immunity underlying talaromyces marneffei infections: a multicenter, retrospective cohort study. Front Immunol. 2025;16:1492000.","journal-title":"Front Immunol"},{"key":"10973_CR13","doi-asserted-by":"publisher","first-page":"4783","DOI":"10.2147\/IDR.S479629","volume":"17","author":"H Liang","year":"2024","unstructured":"Liang H, Duan X, Li T, Hu L, Guo J. Disseminated combined talaromyces marneffei and enterococcus faecium bloodstream infection presenting as gastrointestinal perforation in a patient with CARD9 gene mutation. Infect Drug Resist. 2024;17:4783\u201390.","journal-title":"Infect Drug Resist"},{"key":"10973_CR14","doi-asserted-by":"publisher","first-page":"110293","DOI":"10.1016\/j.clim.2024.110293","volume":"265","author":"LH Zhou","year":"2024","unstructured":"Zhou LH, Qiu WJ, Que CX, Cheng JH, Zhu RS, Huang JT, et al. A novel inherited CARD9 deficiency in an otherwise healthy woman with CNS candidiasis. Clin Immunol. 2024;265:110293.","journal-title":"Clin Immunol"},{"issue":"1","key":"10973_CR15","doi-asserted-by":"publisher","first-page":"101455","DOI":"10.1016\/j.mycmed.2023.101455","volume":"34","author":"N Ma","year":"2024","unstructured":"Ma N, Zhao Y, Tang M, Xia H, Li D, Lu G. Concurrent infection of exophiala dermatitidis and angiostrongylus cantonensis in central nervous system of a child with inherited CARD9 deficiency: a case report and literature review. J Mycol Med. 2024;34(1):101455.","journal-title":"J Mycol Med"},{"issue":"5","key":"10973_CR16","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s10875-024-01724-7","volume":"44","author":"D Tomomasa","year":"2024","unstructured":"Tomomasa D, Lee BH, Hirata Y, Inoue Y, Majima H, Imanaka Y, et al. Inherited CARD9 deficiency due to a founder effect in East Asia. J Clin Immunol. 2024;44(5):121.","journal-title":"J Clin Immunol"},{"issue":"16","key":"10973_CR17","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1097\/CM9.0000000000002786","volume":"136","author":"X Xu","year":"2023","unstructured":"Xu X, Lu H, Li J, Duan J, Wang Z, Yang J, et al. Heterozygous CARD9 mutation favors the development of allergic bronchopulmonary aspergillosis. Chin Med J (Engl). 2023;136(16):1949\u201358.","journal-title":"Chin Med J (Engl)"},{"issue":"20","key":"10973_CR18","doi-asserted-by":"publisher","first-page":"e33798","DOI":"10.1097\/MD.0000000000033798","volume":"102","author":"R Deng","year":"2023","unstructured":"Deng R, Meng X, Li R, Wang A, Song Y. Asymptomatic Candida glabrata urinary tract infection in an immunocompetent young female: a case report. Med (Baltim). 2023;102(20):e33798.","journal-title":"Med (Baltim)"},{"issue":"10","key":"10973_CR19","doi-asserted-by":"publisher","first-page":"omad103","DOI":"10.1093\/omcr\/omad103","volume":"2023","author":"M Fallahi","year":"2023","unstructured":"Fallahi M, Mahdaviani SA, Shafiei M, Ghadimi S, Rezaei N, Klein C, et al. CARD9 deficiency with allergic bronchopulmonary aspergillosis (ABPA)-like presentation: a case report. Oxf Med Case Rep. 2023;2023(10):omad103.","journal-title":"Oxf Med Case Rep"},{"issue":"3","key":"10973_CR20","doi-asserted-by":"publisher","first-page":"e13712","DOI":"10.1111\/myc.13712","volume":"67","author":"MDS Dantas","year":"2024","unstructured":"Dantas MDS, Cintra MEC, Lucini F, Venturini J, de Souza GHA, Rossato L. CARD9 mutations in patients with fungal infections: an update from the last 5 years. Mycoses. 2024;67(3):e13712.","journal-title":"Mycoses"},{"issue":"6","key":"10973_CR21","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1007\/s11046-020-00487-0","volume":"185","author":"X Wang","year":"2020","unstructured":"Wang X, Ding H, Chen Z, Zeng X, Sun J, Chen H, et al. CARD9 deficiency in a Chinese man with cutaneous mucormycosis, recurrent deep dermatophytosis and a review of the literature. Mycopathologia. 2020;185(6):1041\u201350.","journal-title":"Mycopathologia"},{"issue":"2","key":"10973_CR22","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s10875-020-00909-0","volume":"41","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Huang C, Song Y, Ma Y, Wan Z, Zhu X, et al. Primary cutaneous aspergillosis in a patient with CARD9 deficiency and aspergillus susceptibility of Card9 knockout mice. J Clin Immunol. 2021;41(2):427\u201340.","journal-title":"J Clin Immunol"},{"issue":"3","key":"10973_CR23","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.jid.2017.10.009","volume":"138","author":"X Wang","year":"2018","unstructured":"Wang X, Zhang R, Wu W, Song Y, Wan Z, Han W, et al. Impaired specific antifungal immunity in CARD9-deficient patients with phaeohyphomycosis. J Invest Dermatol. 2018;138(3):607\u201317.","journal-title":"J Invest Dermatol"},{"issue":"4","key":"10973_CR24","doi-asserted-by":"publisher","first-page":"e0160821","DOI":"10.1128\/mBio.01608-21","volume":"12","author":"E Zajta","year":"2021","unstructured":"Zajta E, Csonka K, T\u00f3th A, Tiszlavicz L, N\u00e9meth T, Orosz A, et al. Signaling through Syk or CARD9 mediates species-specific anti-candida protection in bone marrow chimeric mice. mBio. 2021;12(4):e0160821.","journal-title":"mBio"},{"issue":"2","key":"10973_CR25","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/s41419-017-0084-6","volume":"9","author":"X Zhong","year":"2018","unstructured":"Zhong X, Chen B, Yang L, Yang Z. Molecular and physiological roles of the adaptor protein CARD9 in immunity. Cell Death Dis. 2018;9(2):52.","journal-title":"Cell Death Dis"},{"key":"10973_CR26","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.mib.2017.11.004","volume":"40","author":"M Shiokawa","year":"2017","unstructured":"Shiokawa M, Yamasaki S, Saijo S. C-type lectin receptors in anti-fungal immunity. Curr Opin Microbiol. 2017;40:123\u201330.","journal-title":"Curr Opin Microbiol"},{"issue":"8","key":"10973_CR27","first-page":"2203","volume":"10","author":"Y Wang","year":"2020","unstructured":"Wang Y, Zhang D, Hou Y, Shen S, Wang T. The adaptor protein CARD9, from fungal immunity to tumorigenesis. Am J Cancer Res. 2020;10(8):2203\u201325.","journal-title":"Am J Cancer Res"},{"key":"10973_CR28","doi-asserted-by":"crossref","unstructured":"Drummond RA, Desai JV, Hsu AP, Oikonomou V, Vinh DC, Acklin JA et al. Human Dectin-1 deficiency impairs macrophage-mediated defense against phaeohyphomycosis. J Clin Invest. 2022;132(22).","DOI":"10.1172\/JCI159348"},{"issue":"3","key":"10973_CR29","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/cmi.2012.1","volume":"9","author":"A Carvalho","year":"2012","unstructured":"Carvalho A, Giovannini G, De Luca A, D\u2019Angelo C, Casagrande A, Iannitti RG, et al. Dectin-1 isoforms contribute to distinct Th1\/Th17 cell activation in mucosal candidiasis. Cell Mol Immunol. 2012;9(3):276\u201386.","journal-title":"Cell Mol Immunol"},{"issue":"2","key":"10973_CR30","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.immuni.2013.05.017","volume":"39","author":"LL Zhu","year":"2013","unstructured":"Zhu LL, Zhao XQ, Jiang C, You Y, Chen XP, Jiang YY, et al. C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection. Immunity. 2013;39(2):324\u201334.","journal-title":"Immunity"},{"issue":"Suppl 3","key":"10973_CR31","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/1469-0691.12515","volume":"20","author":"A Chowdhary","year":"2014","unstructured":"Chowdhary A, Meis JF, Guarro J, de Hoog GS, Kathuria S, Arendrup MC, et al. ESCMID and ECMM joint clinical guidelines for the diagnosis and management of systemic phaeohyphomycosis: diseases caused by black fungi. Clin Microbiol Infect. 2014;20(Suppl 3):47\u201375.","journal-title":"Clin Microbiol Infect"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-025-10973-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12879-025-10973-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-025-10973-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T11:57:03Z","timestamp":1745755023000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-025-10973-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,27]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["10973"],"URL":"https:\/\/doi.org\/10.1186\/s12879-025-10973-9","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,27]]},"assertion":[{"value":"21 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The studies involving human participants were reviewed and approved by the ethics committee of Shandong Provincial Hospital, affiliated to Shandong First Medical University. The patient provided written informed consent for their participation in the study and for the publication of potentially identifiable images or data included in this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors have consented to publication. The patient and other participants provided written informed consent for their personal or clinical details along with any identifying images to be published in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}],"article-number":"613"}}