{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T04:09:12Z","timestamp":1745640552031,"version":"3.40.4"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Institute of Neuroscience and Brain Science, Affiliated Hospital of Hubei University of Arts and Science","award":["2023NBI07"],"award-info":[{"award-number":["2023NBI07"]}]},{"name":"the project of Xiangyang Central Hospital","award":["2024BS03"],"award-info":[{"award-number":["2024BS03"]}]},{"name":"the Hubei Provincial Natural Science Foundation and Xiangyang of China","award":["2025AFD068"],"award-info":[{"award-number":["2025AFD068"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82301374"],"award-info":[{"award-number":["82301374"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the science and technology plan of Xiangyang City in Hubei Province","award":["2021YL03"],"award-info":[{"award-number":["2021YL03"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"DOI":"10.1186\/s12879-025-10997-1","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T20:07:58Z","timestamp":1745611678000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["First detection of HBV nucleic acid in the lung tissue of a patient with spontaneous recovery from HBV infection by tNGS: a case report"],"prefix":"10.1186","volume":"25","author":[{"given":"Li","family":"Zhenzhen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dai","family":"Xiaoqing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhou","family":"Lan-Ting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Xiaoxia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shui","family":"Xiaochuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Ming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Zhengjiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huang","family":"Shaojun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"issue":"2","key":"10997_CR1","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.jhep.2017.03.021","volume":"67","author":"P Lampertico","year":"2017","unstructured":"Lampertico P, Agarwal K, Berg T, Buti M, Janssen HLA, Papatheodoridis G, Zoulim F, Tacke F. EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection. J Hepatol. 2017;67(2):370\u201398.","journal-title":"J Hepatol"},{"issue":"1","key":"10997_CR2","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jhep.2024.02.017","volume":"81","author":"BC Narmada","year":"2024","unstructured":"Narmada BC, Khakpoor A, Shirgaonkar N, Narayanan S, Aw PPK, Singh M, Ong KH, Owino CO, Ng JWT, Yew HC, et al. Single-cell landscape of functionally cured chronic hepatitis B patients reveals activation of innate and altered CD4-CTL-driven adaptive immunity. J Hepatol. 2024;81(1):42\u201361.","journal-title":"J Hepatol"},{"issue":"2","key":"10997_CR3","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.jhep.2018.03.021","volume":"69","author":"GP Caviglia","year":"2018","unstructured":"Caviglia GP, Abate ML, Tandoi F, Ciancio A, Amoroso A, Salizzoni M, Saracco GM, Rizzetto M, Romagnoli R, Smedile A. Quantitation of HBV CccDNA in anti-HBc-positive liver donors by droplet digital PCR: A new tool to detect occult infection. J Hepatol. 2018;69(2):301\u20137.","journal-title":"J Hepatol"},{"issue":"9","key":"10997_CR4","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/S2352-4642(23)00148-7","volume":"7","author":"H Wang","year":"2023","unstructured":"Wang H, Song Y, Ma J, Ma S, Shen L, Huang Y, Thangaraju P, Basharat Z, Hu Y, Lin Y, et al. Burden of non-communicable diseases among adolescents and young adults aged 10\u201324 years in the South-East Asia and Western Pacific regions, 1990\u20132019: a systematic analysis for the global burden of disease study 2019. Lancet Child Adolesc Health. 2023;7(9):621\u201335.","journal-title":"Lancet Child Adolesc Health"},{"issue":"6","key":"10997_CR5","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1093\/infdis\/jiae248","volume":"230","author":"T Grudda","year":"2024","unstructured":"Grudda T, Thomas DL, Kirk GD, Mehta SH, Astemborski J, Lauer GM, Balagopal A, Thio CL. Hepatitis B virus DNA and RNA persist in liver after serologic recovery in persons with hepatitis C virus. J Infect Dis. 2024;230(6):1352\u20136.","journal-title":"J Infect Dis"},{"key":"10997_CR6","doi-asserted-by":"publisher","first-page":"103003","DOI":"10.1016\/j.eclinm.2024.103003","volume":"79","author":"S Shrestha","year":"2025","unstructured":"Shrestha S, Addae A, Miller C, Ismail N, Zwerling A. Cost-effectiveness of targeted next-generation sequencing (tNGS) for detection of tuberculosis drug resistance in India, South Africa and Georgia: a modeling analysis. EClinicalMedicine. 2025;79:103003.","journal-title":"EClinicalMedicine"},{"key":"10997_CR7","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1038\/nm1096-1104","volume":"2","author":"B Rehermann","year":"1996","unstructured":"Rehermann B, Ferrari C, Pasquinelli C, Chisari FV. The hepatitis B virus persists for decades after patients\u2019 recovery from acute viral hepatitis despite active maintenance of a cytotoxic T\u2013lymphocyte response. Nat Med. 1996;2:1104\u20138.","journal-title":"Nat Med"},{"issue":"40","key":"10997_CR8","doi-asserted-by":"publisher","first-page":"5784","DOI":"10.3748\/wjg.v28.i40.5784","volume":"28","author":"GQ Yin","year":"2022","unstructured":"Yin GQ, Chen KP, Gu XC. Heterogeneity of immune control in chronic hepatitis B virus infection: clinical implications on immunity with interferon-alpha treatment and retreatment. World J Gastroenterol. 2022;28(40):5784\u2013800.","journal-title":"World J Gastroenterol"},{"key":"10997_CR9","doi-asserted-by":"crossref","unstructured":"Faure-Dupuy S, Lucifora J, Durantel D. Interplay between the hepatitis B virus and innate immunity: from an Understanding to the development of therapeutic concepts. Viruses. 2017; 9(5).","DOI":"10.3390\/v9050095"},{"issue":"4","key":"10997_CR10","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1002\/hep.32622","volume":"77","author":"K Zhao","year":"2023","unstructured":"Zhao K, Guo F, Wang J, Zhong Y, Yi J, Teng Y, Xu Z, Zhao L, Li A, Wang Z, et al. Limited disassembly of cytoplasmic hepatitis B virus nucleocapsids restricts viral infection in murine hepatic cells. Hepatology. 2023;77(4):1366\u201381.","journal-title":"Hepatology"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-025-10997-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12879-025-10997-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-025-10997-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T20:07:59Z","timestamp":1745611679000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-025-10997-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,25]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["10997"],"URL":"https:\/\/doi.org\/10.1186\/s12879-025-10997-1","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,25]]},"assertion":[{"value":"7 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This was a retrospective study based on the clinical tNGS result. Approval for this study was obtained from the research ethics board of Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science. The patient provided informed consent for inclusion prior to participation in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The patients were informed to the use of their clinical data and personal information in this study. And all participants provided written informed consent for publication of their data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"607"}}